PTK7 and DUSP15

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		PTK7	DUSP15
Description		protein tyrosine kinase 7 (inactive)	dual specificity phosphatase 15
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Axon Neuronal Cell Body Anchoring Junction	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Coreceptor Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity
	Biological Process	Establishment Of Planar Polarity Kidney Development Neural Tube Closure Ventricular Septum Development Axis Elongation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Axon Guidance Heart Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Cell Migration Actin Cytoskeleton Organization Wound Healing Establishment Of Epithelial Cell Apical/basal Polarity Synapse Organization Convergent Extension Lung-associated Mesenchyme Development Regulation Of Canonical Wnt Signaling Pathway Coronary Vasculature Development Cellular Response To Retinoic Acid Cochlea Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction Dephosphorylation Regulation Of Oligodendrocyte Differentiation Positive Regulation Of ERK1 And ERK2 Cascade
Pathways
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		41 interacting genes: CDC14A CLNK CTDSP2 CYSRT1 DUSP10 DUSP14 DUSP15 DUSP18 DUSP19 DUSP21 DUSP26 DUSP29 ERBB2 ILKAP KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP5-9 MDFI MTMR1 MTMR10 MTMR6 MTMR9 MTUS2 NBPF19 NOTCH2NLA PPM1A PPM1B PPM1F PPM1K PPP3CA PPP3CB PTEN PTPN11 PTPN12 PTPN6 PTPN7 PTPRR STYX TPTE TPTE2	2 interacting genes: IGF1R PTK7
Entrez ID		5754	128853
HPRD ID		03534	13252
Ensembl ID		ENSG00000112655	ENSG00000149599
Uniprot IDs		Q13308	Q9H1R2
PDB IDs		6VG3	1YZ4
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Hydrolase Activity Phosphate-containing Compound Metabolic Process Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Cation Binding Peptidyl-tyrosine Dephosphorylation Non-membrane Spanning Protein Tyrosine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Regulation Of ERK1 And ERK2 Cascade Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Protein Modification Process MAP Kinase Phosphatase Activity Phosphatidylinositol Dephosphorylation Regulation Of MAPK Cascade Cytoplasm Phospholipid Dephosphorylation Regulation Of Intracellular Signal Transduction Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Epithelial Cell Migration Cytosol Phosphatidylinositol Metabolic Process N-terminal Protein Myristoylation Regulation Of Epithelial Cell Migration Negative Regulation Of T Cell Proliferation Negative Regulation Of Signaling Phosphatidylinositol Phosphate Phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Phosphatidylinositol Dephosphorylation Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Regulation Of Lymphocyte Activation Protein Metabolic Process Negative Regulation Of Lymphocyte Proliferation Regulation Of Leukocyte Proliferation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Neutrophil Activation Negative Regulation Of Developmental Growth Regulation Of Oligodendrocyte Differentiation	Insulin-like Growth Factor Receptor Activity Protein Kinase Complex Insulin Receptor Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Insulin Binding Insulin Receptor Activity Heart Development Protein O-linked Glycosylation Via Fucose Peptide-O-fucosyltransferase Activity Axon Peptidyl-tyrosine Autophosphorylation Insulin-like Growth Factor Binding Protein Kinase Activity Cell Surface Receptor Signaling Pathway Insulin-like Growth Factor I Binding Dendritic Spine Maintenance Insulin Receptor Substrate Binding Protein Transporter Activity Lung-associated Mesenchyme Development Axon Guidance Receptor Activity Convergent Extension Fucose Metabolic Process Phosphatidylinositol 3-kinase Binding Establishment Of Epithelial Cell Apical/basal Polarity Axis Elongation Transcytosis Insulin Receptor Binding Establishment Of Planar Polarity Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Amyloid-beta Clearance Coronary Vasculature Development Cochlea Morphogenesis Establishment Of Epithelial Cell Polarity Regulation Of Signal Transduction Dendritic Spine Organization Insulin-like Growth Factor Receptor Signaling Pathway Ventricular Septum Development Positive Regulation Of Protein-containing Complex Disassembly Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Activity Neuron Projection Organization Cellular Response To Amyloid-beta Plasma Membrane Bounded Cell Projection Organization Postsynapse Organization Peptidyl-tyrosine Phosphorylation Cellular Response To Oxygen-containing Compound
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