PTK7 and MTMR10

Number of citations: 51 (PubMedID 28065597)
Data Source: BioGRID (two hybrid)

		PTK7	MTMR10
Name		protein tyrosine kinase 7 (inactive)	myotubularin related protein 10
Structure			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Axon Neuronal Cell Body Anchoring Junction	Cytoplasm Cytosol Membrane
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Coreceptor Activity	None
	Biological Process	Establishment Of Planar Polarity Kidney Development Neural Tube Closure Ventricular Septum Development Axis Elongation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Axon Guidance Heart Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Cell Migration Actin Cytoskeleton Organization Wound Healing Establishment Of Epithelial Cell Apical/basal Polarity Synapse Organization Convergent Extension Lung-associated Mesenchyme Development Regulation Of Canonical Wnt Signaling Pathway Coronary Vasculature Development Cellular Response To Retinoic Acid Cochlea Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway	None
Pathways		None	Synthesis of PIPs at the early endosome membrane
GWAS		Coronary artery disease ( 29212778 )	Huntington's disease progression ( 28642124 ) Hypertriglyceridemia ( 23505323 )
Novel Interactors		10 novel interactors: BYSL CDKN1A CLIC5 ENPP5 PSMB9 RPS2 RTN4R TNFRSF21 TRAM2 VGLL1	None recorded
Interacting Genes		41 interacting genes: CDC14A CLNK CTDSP2 CYSRT1 DUSP10 DUSP14 DUSP15 DUSP18 DUSP19 DUSP21 DUSP26 DUSP29 ERBB2 ILKAP KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP5-9 MDFI MTMR1 MTMR10 MTMR6 MTMR9 MTUS2 NBPF19 NOTCH2NLA PPM1A PPM1B PPM1F PPM1K PPP3CA PPP3CB PTEN PTPN11 PTPN12 PTPN6 PTPN7 PTPRR STYX TPTE TPTE2	10 interacting genes: AATK DSCAM ERBB3 HUNK LCOR MEOX2 NRIP1 PTK7 SMAD5 SMAD9
Entrez ID		5754	54893
HPRD ID		03534	07895
Ensembl ID		ENSG00000112655	ENSG00000166912
Uniprot IDs		Q13308	Q9NXD2 X5D963
PDB IDs		6VG3	Not available
GO Terms Enriched among Interactors		Phosphoprotein Phosphatase Activity Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Hydrolase Activity Phosphate-containing Compound Metabolic Process Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Cation Binding Peptidyl-tyrosine Dephosphorylation Non-membrane Spanning Protein Tyrosine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Regulation Of ERK1 And ERK2 Cascade Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Protein Modification Process MAP Kinase Phosphatase Activity Phosphatidylinositol Dephosphorylation Regulation Of MAPK Cascade Cytoplasm Phospholipid Dephosphorylation Regulation Of Intracellular Signal Transduction Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Epithelial Cell Migration Cytosol Phosphatidylinositol Metabolic Process N-terminal Protein Myristoylation Regulation Of Epithelial Cell Migration Negative Regulation Of T Cell Proliferation Negative Regulation Of Signaling Phosphatidylinositol Phosphate Phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Phosphatidylinositol Dephosphorylation Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Regulation Of Lymphocyte Activation Protein Metabolic Process Negative Regulation Of Lymphocyte Proliferation Regulation Of Leukocyte Proliferation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Neutrophil Activation Negative Regulation Of Developmental Growth Regulation Of Oligodendrocyte Differentiation	Heteromeric SMAD Protein Complex SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Protein Kinase Activity Cellular Response To Estradiol Stimulus Nuclear Estrogen Receptor Binding Tissue Development Mesenchyme Development Embryonic Pattern Specification Ovarian Follicle Rupture Intracellular Iron Ion Homeostasis Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Wound Healing Negative Regulation Of Fas Signaling Pathway BMP Signaling Pathway Neuregulin Receptor Activity Neuron Apoptotic Process Stem Cell Differentiation Osteoblast Fate Commitment Transforming Growth Factor Beta Receptor Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Response To Estradiol Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Protein Tyrosine Kinase Activity Striated Muscle Tissue Development Osteoblast Differentiation Regulation Of Fas Signaling Pathway Anti-Mullerian Hormone Receptor Signaling Pathway Mullerian Duct Regression Chromatin Somite Specification Cellular Response To Lipid Histone Deacetylase Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Axon Extension Involved In Axon Guidance Muscle Tissue Development Schwann Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Kinase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway DEAD/H-box RNA Helicase Binding Netrin-activated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway