JAG1 and AFDN

Number of citations: 36 (PubMedID 9707552)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		JAG1	AFDN
Name		jagged canonical Notch ligand 1	afadin, adherens junction formation factor
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Adherens Junction Membrane Apical Plasma Membrane Apical Part Of Cell	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction Anchoring Junction
	Molecular Function	Notch Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Phospholipid Binding Growth Factor Activity Molecular Adaptor Activity	Protein Binding Small GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding
	Biological Process	Angiogenesis Cell Fate Determination Negative Regulation Of Cell-matrix Adhesion Blood Vessel Remodeling Morphogenesis Of An Epithelial Sheet Inhibition Of Neuroepithelial Cell Differentiation T Cell Mediated Immunity Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Cell Communication Notch Signaling Pathway Nervous System Development Animal Organ Morphogenesis Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell-cell Adhesion Hemopoiesis Neuron Differentiation Keratinocyte Differentiation Negative Regulation Of Cell Migration Response To Muramyl Dipeptide Aorta Morphogenesis Regulation Of Cell Population Proliferation Inner Ear Auditory Receptor Cell Differentiation Camera-type Eye Development Myoblast Differentiation Endothelial Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development System Development Inner Ear Development Regulation Of Epithelial Cell Proliferation Cardiac Septum Morphogenesis Ciliary Body Morphogenesis Neuroendocrine Cell Differentiation Pulmonary Artery Morphogenesis Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Endocardial Cushion Cell Development Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Nephron Development Podocyte Development Distal Tubule Development Loop Of Henle Development Neuronal Stem Cell Population Maintenance Negative Regulation Of Stem Cell Differentiation	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Cell Differentiation Negative Regulation Of Cell Migration Regulation Of Protein Localization Cell Junction Organization Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus RUNX3 regulates NOTCH signaling RAC1 GTPase cycle RAC3 GTPase cycle NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Nephron development	None
Drugs		None	(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
Diseases		Tetralogy of Fallot Alagille syndrome	None
GWAS		Appendicular lean mass ( 33097823 ) Birth weight ( 31043758 27680694 ) Blood pressure ( 21909110 ) Bone mineral density ( 20096396 ) Bone mineral density (spine) ( 30172743 ) Brain morphology (MOSTest) ( 32665545 ) Cardiac hypertrophy ( 21348951 ) Cataracts ( 34127677 ) Cataracts (operation) ( 31816047 ) Diastolic blood pressure ( 21909115 27618447 27618452 26390057 27841878 25249183 28135244 28739976 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Eosinophil count ( 32888494 ) Frontotemporal dementia (age at onset) ( 29724592 ) Frontotemporal dementia with GRN mutation (age at onset) ( 29724592 ) Heel bone mineral density ( 30598549 28869591 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Lumbar spine bone mineral density ( 22504420 29499414 ) Lymphocyte count ( 32888494 ) Migraine ( 27322543 ) Offspring birth weight ( 31043758 ) Pulse pressure ( 28135244 ) Red blood cell count ( 32888494 ) Systolic blood pressure ( 28739976 28135244 27841878 25249183 27618452 21909115 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Type 2 diabetes ( 28828242 ) Urate levels ( 31578528 ) Urinary bladder cancer ( 24861552 )	Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906 )
Novel Interactors		1 novel interactors: SH2D4A	2 novel interactors: CCR6 RPS6KA2
Interacting Genes		9 interacting genes: AFDN MFNG MIB1 MTDH NOTCH1 NOTCH2 NOTCH3 POFUT1 THBS1	39 interacting genes: BCR CTNNA1 DSCAM EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RNF10 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG
Entrez ID		182	4301
HPRD ID		03562	01164
Ensembl ID		ENSG00000101384	ENSG00000130396
Uniprot IDs		P78504 Q99740	A0A1P7ZIN0 A0A804HJ20 A8MQ02 G1UI22 J3KN01 P55196
PDB IDs		2KB9 2VJ2 4CBZ 4CC0 4CC1 4XI7 5BO1	1T2M 1XZ9 2AIN 2EXG 5A6C 7QCR
GO Terms Enriched among Interactors		Notch Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Tube Morphogenesis Angiogenesis Cellular Response To Tumor Cell Pattern Specification Process Negative Regulation Of Endothelial Cell Chemotaxis Atrioventricular Node Development Glomerular Capillary Formation Heart Looping Embryonic Heart Tube Morphogenesis Negative Regulation Of Neuron Differentiation Marginal Zone B Cell Differentiation Regulation Of Notch Signaling Pathway Blood Vessel Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Left/right Axis Specification Epithelial Tube Morphogenesis Pulmonary Valve Morphogenesis Positive Regulation Of Ras Protein Signal Transduction Epithelial Cell Development Morphogenesis Of An Epithelial Sheet Nephron Tubule Development Positive Regulation Of Smooth Muscle Cell Differentiation Renal Tubule Development Anterior/posterior Pattern Specification Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Mature B Cell Differentiation Involved In Immune Response Regulation Of Neuron Differentiation NF-kappaB Binding Mature B Cell Differentiation Receptor Complex Inflammatory Response To Antigenic Stimulus Sprouting Angiogenesis Positive Regulation Of BMP Signaling Pathway Neuron Fate Commitment Neuron Projection Guidance Axon Guidance Positive Regulation Of Notch Signaling Pathway Calcium Ion Binding Golgi Membrane Regulation Of Smooth Muscle Cell Differentiation In Utero Embryonic Development Cell Surface Receptor Signaling Pathway Regulation Of Ras Protein Signal Transduction Somitogenesis Chordate Embryonic Development Cell Surface Negative Regulation Of Chemotaxis Signal Transduction	Signal Transduction GDP Binding Regulation Of Cell Junction Assembly Plasma Membrane Small GTPase-mediated Signal Transduction Cell Adhesion Ras Protein Signal Transduction Cell-cell Adhesion Cell Adhesion Molecule Binding Membrane Regulation Of Synapse Assembly Adherens Junction G Protein Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Anchoring Junction Ephrin Receptor Activity Regulation Of Cell Projection Organization Transmembrane-ephrin Receptor Activity Neuron Projection Guidance Axon Guidance Protein Localization To Cell Junction GTPase Activity Plasma Membrane Bounded Cell Projection Organization Cell Junction Organization Neuroligin Family Protein Binding Synapse Regulation Of Cellular Component Organization Cell Junction Assembly Modulation Of Chemical Synaptic Transmission Regulation Of Cell Communication Regulation Of Signaling Postsynaptic Membrane Assembly Intracellular Signaling Cassette Regulation Of Synapse Organization Focal Adhesion Negative Regulation Of Cellular Component Organization Apical Junction Complex Regulation Of Locomotion Zonula Adherens Presynaptic Membrane Cell Projection Organization Postsynaptic Membrane Organization Dendrite Regulation Of Cell Projection Assembly Neuron Projection Development GTP Binding Axon Guidance Receptor Activity Cell Adhesion Mediator Activity Regulation Of Cell Motility Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules