JAG1 and MFNG

Number of citations of the paper that reports this interaction (PubMedID 12036964)
0

Data Source:
HPRD (in vivo)

		JAG1	MFNG
Description		jagged canonical Notch ligand 1	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Adherens Junction Membrane Apical Plasma Membrane Apical Part Of Cell	Golgi Membrane Extracellular Space Golgi Apparatus Membrane
	Molecular Function	Notch Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Phospholipid Binding Growth Factor Activity Molecular Adaptor Activity	Transferase Activity Glycosyltransferase Activity O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Activity Metal Ion Binding
	Biological Process	Angiogenesis Cell Fate Determination Negative Regulation Of Cell-matrix Adhesion Blood Vessel Remodeling Morphogenesis Of An Epithelial Sheet Inhibition Of Neuroepithelial Cell Differentiation T Cell Mediated Immunity Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Cell Communication Notch Signaling Pathway Nervous System Development Animal Organ Morphogenesis Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell-cell Adhesion Hemopoiesis Neuron Differentiation Keratinocyte Differentiation Negative Regulation Of Cell Migration Response To Muramyl Dipeptide Aorta Morphogenesis Regulation Of Cell Population Proliferation Inner Ear Auditory Receptor Cell Differentiation Camera-type Eye Development Myoblast Differentiation Endothelial Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development System Development Inner Ear Development Regulation Of Epithelial Cell Proliferation Cardiac Septum Morphogenesis Ciliary Body Morphogenesis Neuroendocrine Cell Differentiation Pulmonary Artery Morphogenesis Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Endocardial Cushion Cell Development Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Nephron Development Podocyte Development Distal Tubule Development Loop Of Henle Development Neuronal Stem Cell Population Maintenance Negative Regulation Of Stem Cell Differentiation	Blastocyst Formation Marginal Zone B Cell Differentiation Pattern Specification Process Regulation Of Notch Signaling Pathway Positive Regulation Of Notch Signaling Pathway
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus RUNX3 regulates NOTCH signaling RAC1 GTPase cycle RAC3 GTPase cycle NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Nephron development	Pre-NOTCH Processing in Golgi
Drugs
Diseases		Tetralogy of Fallot Alagille syndrome
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Blood pressure ( 21909110) Bone mineral density ( 20096396) Bone mineral density (spine) ( 30172743) Brain morphology (MOSTest) ( 32665545) Cardiac hypertrophy ( 21348951) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 21909115 27618447 27618452 26390057 27841878 25249183 28135244 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Eosinophil count ( 32888494) Frontotemporal dementia (age at onset) ( 29724592) Frontotemporal dementia with GRN mutation (age at onset) ( 29724592) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Lumbar spine bone mineral density ( 22504420 29499414) Lymphocyte count ( 32888494) Migraine ( 27322543) Offspring birth weight ( 31043758) Pulse pressure ( 28135244) Red blood cell count ( 32888494) Systolic blood pressure ( 28739976 28135244 27841878 25249183 27618452 21909115) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Type 2 diabetes ( 28828242) Urate levels ( 31578528) Urinary bladder cancer ( 24861552)
Interacting Genes		9 interacting genes: AFDN MFNG MIB1 MTDH NOTCH1 NOTCH2 NOTCH3 POFUT1 THBS1	4 interacting genes: DLL1 JAG1 NOTCH1 NOTCH2
Entrez ID		182	4242
HPRD ID		03562	03988
Ensembl ID		ENSG00000101384	ENSG00000100060
Uniprot IDs		P78504 Q99740	O00587
PDB IDs		2KB9 2VJ2 4CBZ 4CC0 4CC1 4XI7 5BO1
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Tube Morphogenesis Angiogenesis Cellular Response To Tumor Cell Pattern Specification Process Negative Regulation Of Endothelial Cell Chemotaxis Atrioventricular Node Development Glomerular Capillary Formation Heart Looping Embryonic Heart Tube Morphogenesis Negative Regulation Of Neuron Differentiation Marginal Zone B Cell Differentiation Regulation Of Notch Signaling Pathway Blood Vessel Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Left/right Axis Specification Epithelial Tube Morphogenesis Pulmonary Valve Morphogenesis Positive Regulation Of Ras Protein Signal Transduction Epithelial Cell Development Morphogenesis Of An Epithelial Sheet Nephron Tubule Development Positive Regulation Of Smooth Muscle Cell Differentiation Renal Tubule Development Anterior/posterior Pattern Specification Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Mature B Cell Differentiation Involved In Immune Response Regulation Of Neuron Differentiation NF-kappaB Binding Mature B Cell Differentiation Receptor Complex Inflammatory Response To Antigenic Stimulus Sprouting Angiogenesis Positive Regulation Of BMP Signaling Pathway Neuron Fate Commitment Neuron Projection Guidance Axon Guidance Positive Regulation Of Notch Signaling Pathway Calcium Ion Binding Golgi Membrane Regulation Of Smooth Muscle Cell Differentiation In Utero Embryonic Development Cell Surface Receptor Signaling Pathway Regulation Of Ras Protein Signal Transduction Somitogenesis Chordate Embryonic Development Cell Surface Negative Regulation Of Chemotaxis Signal Transduction	Nephron Tubule Development Renal Tubule Development Inhibition Of Neuroepithelial Cell Differentiation Kidney Epithelium Development Notch Signaling Pathway Regulation Of Timing Of Cell Differentiation Regulation Of Development, Heterochronic Left/right Axis Specification Epithelial Cell Development Pulmonary Valve Morphogenesis Morphogenesis Of An Epithelial Sheet Neuronal Stem Cell Population Maintenance Notch Binding Tube Development Neuroepithelial Cell Differentiation Epithelium Development Cell Fate Determination Positive Regulation Of Notch Signaling Pathway Tube Morphogenesis Negative Regulation Of Epithelial Cell Differentiation Ciliary Body Morphogenesis Heart Valve Morphogenesis Cellular Response To Tumor Cell Morphogenesis Of An Epithelium Heart Looping Distal Tubule Development Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Compartment Pattern Specification Embryonic Heart Tube Morphogenesis Cardiac Septum Morphogenesis Negative Regulation Of Neuron Differentiation Tissue Morphogenesis Axis Specification Loop Of Henle Development Regulation Of Embryonic Development Determination Of Bilateral Symmetry Regulation Of Somitogenesis Determination Of Left/right Symmetry Atrioventricular Node Development Regulation Of Notch Signaling Pathway Epidermal Cell Differentiation Proximal Tubule Development Epithelial Tube Morphogenesis Stem Cell Population Maintenance Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Maintenance Of Cell Number Calcium Ion Binding Marginal Zone B Cell Differentiation Regulation Of Inner Ear Auditory Receptor Cell Differentiation
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