JAG1

Gene Name		jagged 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Part Of Cell
	Molecular Function	Notch Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Growth Factor Activity
	Biological Process	Angiogenesis Cell Fate Determination Blood Vessel Remodeling Morphogenesis Of An Epithelial Sheet T Cell Mediated Immunity Pulmonary Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Notch Signaling Pathway Notch Receptor Processing Nervous System Development Hemopoiesis Keratinocyte Differentiation Regulation Of Cell Migration Response To Muramyl Dipeptide Aorta Morphogenesis Regulation Of Cell Proliferation Auditory Receptor Cell Differentiation Myoblast Differentiation Endothelial Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Septum Morphogenesis Ciliary Body Morphogenesis Pulmonary Artery Morphogenesis Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Notch Signaling Involved In Heart Development Endocardial Cushion Cell Development Distal Tubule Development Loop Of Henle Development Neuronal Stem Cell Maintenance Negative Regulation Of Stem Cell Differentiation
Pathways		Signaling by NOTCH4 Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Blood pressure ( 21909110) Bone mineral density ( 20096396 22504420) Cardiac hypertrophy ( 21348951) Diastolic blood pressure ( 21909115) Systolic blood pressure ( 21909115)
Protein-protein Interactions		7 interactors: MFNG MLLT4 NOTCH1 NOTCH2 NOTCH3 POFUT1 THBS1
Entrez ID		182
HPRD ID		03562
Ensembl ID		ENSG00000101384
Uniprot IDs		P78504 Q99740
PDB IDs		2KB9 2VJ2
Enriched GO Terms of Interacting Partners?		Notch Receptor Processing Notch Signaling Pathway Blood Vessel Development Vasculature Development Negative Regulation Of Endothelial Cell Chemotaxis Angiogenesis Cardiovascular System Development Interleukin-4 Secretion Notch Signaling Involved In Heart Development Pulmonary Valve Morphogenesis Blood Vessel Morphogenesis Protein O-linked Fucosylation Interleukin-4 Production Pattern Specification Process Heart Development Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Blood Vessel Endothelial Cell Migration Glomerulus Vasculature Development Negative Regulation Of Chemotaxis Heart Morphogenesis DNA-templated Transcription, Initiation Cardiac Atrium Morphogenesis Developmental Process Tissue Development Inflammatory Response To Antigenic Stimulus Fucosylation Cytokine Secretion Heart Valve Morphogenesis Negative Regulation Of Endothelial Cell Migration Heart Valve Development Positive Regulation Of BMP Signaling Pathway Endocardial Cushion Development Cell Fate Commitment Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Cell-substrate Adhesion Cardiac Septum Morphogenesis Sprouting Angiogenesis Anatomical Structure Formation Involved In Morphogenesis Epithelium Development Glomerulus Development Morphogenesis Of An Epithelial Sheet Inflammatory Response Anatomical Structure Morphogenesis Endothelial Cell Differentiation Neuron Fate Commitment Positive Regulation Of Signal Transduction Negative Regulation Of Angiogenesis Cardiac Septum Development Regulation Of BMP Signaling Pathway
Tagcloud ?		activating beta1 concert contact dephosphorylates egfr importantly interestingly interplay jagged kappa keratinocyte keratinocytes ligand limiting notch notch1 phosphatase ptprk responsive sb431542 secretase smad3 sparse stimulate substantially suppresses tgf thereby