SRGAP1 and BMPR1B

Number of citations of the paper that reports this interaction (PubMedID 15761153)
0

Data Source:
HPRD (in vivo)

		SRGAP1	BMPR1B
Description		SLIT-ROBO Rho GTPase activating protein 1	bone morphogenetic protein receptor type 1B
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Plasma Membrane Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Kinase Activity Transferase Activity BMP Binding SMAD Binding Metal Ion Binding BMP Receptor Activity
	Biological Process	Signal Transduction Rho Protein Signal Transduction Nervous System Development Cell Migration Negative Regulation Of Cell Migration Regulation Of Synapse Assembly	Cartilage Condensation Ovarian Cumulus Expansion Osteoblast Differentiation Eye Development Chondrocyte Differentiation Chondrocyte Development Inflammatory Response Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Dorsal/ventral Pattern Formation Positive Regulation Of Gene Expression Central Nervous System Neuron Differentiation Cell Differentiation Proteoglycan Biosynthetic Process Positive Regulation Of Bone Mineralization BMP Signaling Pathway Retinal Ganglion Cell Axon Guidance Positive Regulation Of Chondrocyte Differentiation Ovulation Cycle Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development Retina Development In Camera-type Eye Bone Development Endochondral Bone Morphogenesis Positive Regulation Of Cartilage Development Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Chondrocyte Proliferation
Pathways		Inactivation of CDC42 and RAC1 RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	Signaling by BMP
Drugs			Fostamatinib
Diseases			Acromesomelic dysplasia with genital anomalies Brachydactyly, including: type A; type B; type D; type E
GWAS		Bone erosion in rheumatoid arthritis ( 28512992) Cerebral microbleeds ( 31209788) Epithelial ovarian cancer ( 25134534) PR interval ( 32439900)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Attention deficit hyperactivity disorder ( 20732626) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778 33020668) Diverticular disease ( 30177863) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) Hen's egg allergy ( 29051540) Maximum stenosis ( 32469969) Opioid dependence (time to event) ( 34124712) Polycystic ovary syndrome (reproductive subtype) ( 32574161) Prepulse inhibition of the startle response ( 31596458) Schizophrenia ( 30470734) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Systolic blood pressure ( 30578418 30224653) Waist-hip ratio ( 28552196)
Interacting Genes		6 interacting genes: BMPR1B CDC42 FASLG RAC1 RHOA ROBO1	64 interacting genes: AMHR2 APP ARHGEF6 BAMBI BMP15 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR2 CDK14 CDK4 CHN1 DCAF12 DCAF6 DCAF7 FANCL GDF5 GDF6 GDF9 KLHL1 LZTR1 NKIRAS1 OTUB1 OXSR1 PAK1 PLEKHB1 POMK PPP2CA PPP3CC RAB25 RAB38 RAB6B RAN RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 SASH3 SH3KBP1 SMAD6 SMAD7 SNX6 SOCS6 SQSTM1 SRGAP1 STAMBP STK35 STUB1 TGFBR1 TNNT1 TRAF6 TTC17 TTC27 UBA52 UBE2Z UBXN1 USP45 VEPH1
Entrez ID		57522	658
HPRD ID		09406	04457
Ensembl ID		ENSG00000196935	ENSG00000138696
Uniprot IDs		Q7Z6B7	A8KAE3 O00238
PDB IDs			3MDY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Actin Filament Bundle Assembly G Protein Activity Roundabout Signaling Pathway G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cell Surface Receptor Signaling Pathway Regulation Of Stress Fiber Assembly Thioesterase Binding Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Dendrite Neuron Projection Development Establishment Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Supramolecular Fiber Organization Cellular Developmental Process Cell-cell Junction Organization Establishment Of Apical/basal Cell Polarity Positive Regulation Of Cytoskeleton Organization Anatomical Structure Morphogenesis GTP-dependent Protein Binding Polarized Epithelial Cell Differentiation Membrane Organization Regulation Of Signal Transduction Regulation Of Plasma Membrane Bounded Cell Projection Organization Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cell Projection Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Rho Protein Signal Transduction Regulation Of Cell-substrate Adhesion Establishment Of Epithelial Cell Polarity Neuron Projection Guidance Axon Guidance Cerebral Cortex Cell Migration Phagocytosis, Engulfment Regulation Of Cell Population Proliferation Postsynapse Positive Regulation Of Lamellipodium Organization Regulation Of Cell Communication Regulation Of Signaling Actin Filament Organization Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction	Regulation Of SMAD Protein Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cartilage Development Response To Growth Factor Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cartilage Development Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Cellular Response To BMP Stimulus GTPase Activity Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling GTP Binding Positive Regulation Of Bone Mineralization Cardiac Septum Morphogenesis Ubiquitin Protein Ligase Binding Regulation Of Ossification Nucleotide Binding Positive Regulation Of Biomineral Tissue Development Regulation Of Chondrocyte Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Ossification Transmembrane Receptor Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Regulation Of Osteoblast Differentiation Mesenchyme Development BMP Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Growth Factor Activity Negative Regulation Of Signal Transduction Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Motility Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Locomotion Intracellular Signal Transduction Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Signaling Negative Regulation Of Cell Communication Post-translational Protein Modification Regulation Of Cell Migration
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