SRGAP1 and ROBO1

Number of citations of the paper that reports this interaction (PMID 11672528)
105

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		SRGAP1	ROBO1
Gene Name		SLIT-ROBO Rho GTPase activating protein 1	roundabout, axon guidance receptor, homolog 1 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axolemma
	Molecular Function	Protein Binding Rac GTPase Activator Activity Rac GTPase Binding	Protein Binding Axon Guidance Receptor Activity LRR Domain Binding Identical Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Rac GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Cell Migration Involved In Sprouting Angiogenesis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Axon Midline Choice Point Recognition Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Roundabout Signaling Pathway Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Mammary Duct Terminal End Bud Growth Negative Regulation Of Chemokine-mediated Signaling Pathway
Pathways		Inactivation of Cdc42 and Rac Rho GTPase cycle Axon guidance Signaling by Rho GTPases Signaling by Robo receptor	Inactivation of Cdc42 and Rac Role of Abl in Robo-Slit signaling Axon guidance Activation of Rac Regulation of Commissural axon pathfinding by Slit and Robo Netrin-1 signaling Signaling by Robo receptor
Drugs
Diseases
GWAS			Brain imaging in schizophrenia (interaction) ( 19023125) Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		5 interactors: BMPR1B CDC42 FASLG RHOA ROBO1	8 interactors: ABL1 MAPK14 ROBO2 SLIT1 SLIT2 SRGAP1 SRGAP2 TUBB3
Entrez ID		57522	6091
HPRD ID		09406	03890
Ensembl ID		ENSG00000196935	ENSG00000169855
Uniprot IDs		Q7Z6B7	Q1RMC8 Q9Y6N7
PDB IDs			2EO9 2V9Q 2V9R 2V9T
Enriched GO Terms of Interacting Partners?		Axon Guidance Regulation Of Cell Proliferation Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Chemotaxis Positive Regulation Of Cell Death Neuron Projection Morphogenesis Cell Development Response To External Stimulus Positive Regulation Of Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Involved In Differentiation Negative Chemotaxis Neuron Projection Development Cell Projection Morphogenesis Positive Regulation Of Cell Differentiation Cell Part Morphogenesis Anatomical Structure Morphogenesis Neuron Development Organ Morphogenesis Positive Regulation Of Cell Projection Organization Cell Morphogenesis Regulation Of Signal Transduction Substantia Nigra Development Neuron Differentiation Positive Regulation Of Cytokinesis Cell Projection Organization Organ Development Locomotion Positive Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Neural Nucleus Development Sprouting Angiogenesis Regulation Of Cytokinesis Positive Regulation Of Neuron Apoptotic Process Cell Differentiation Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Growth Regulation Of Cell Death Generation Of Neurons Positive Regulation Of Cell Development Regulation Of Cell Differentiation Morphogenesis Of An Epithelium Regulation Of Epidermal Growth Factor Receptor Signaling Pathway	Chemotaxis Axon Guidance Cell Morphogenesis Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Response To External Stimulus Neuron Development Neuron Differentiation Cell Projection Organization Negative Regulation Of Locomotion Anatomical Structure Morphogenesis Regulation Of Locomotion Retinal Ganglion Cell Axon Guidance Generation Of Neurons Neurogenesis Negative Regulation Of Chemotaxis Cell Development Cell Differentiation Apoptotic Process Involved In Luteolysis Regulation Of Negative Chemotaxis Negative Regulation Of Cellular Component Movement Nervous System Development Dorsal/ventral Axon Guidance Luteolysis System Development Regulation Of Cellular Component Movement Developmental Growth Brain Development Regulation Of Cell Differentiation Head Development Developmental Cell Growth Multicellular Organismal Development Olfactory Bulb Interneuron Development Anatomical Structure Development Axon Extension Involved In Axon Guidance Central Nervous System Development Forebrain Development Developmental Process Olfactory Bulb Interneuron Differentiation Regulation Of Chemotaxis Growth Developmental Growth Involved In Morphogenesis
Tagcloud ?			adjacent altogether anomalously coil coiled di e2f1 evidences generating great h3k27me3 homolog metastasis noncancerous nsclc oncogene paired partly polycomb prc2 qrt repressive rho rock1 roundabout silencing suz12 tri zeste
Tagcloud (Difference) ?			adjacent altogether anomalously coil coiled di e2f1 evidences generating great h3k27me3 homolog metastasis noncancerous nsclc oncogene paired partly polycomb prc2 qrt repressive rho rock1 roundabout silencing suz12 tri zeste
Tagcloud (Intersection) ?