SRGAP1 and ROBO1

Number of citations of the paper that reports this interaction (PubMedID 11672528)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SRGAP1	ROBO1
Description		SLIT-ROBO Rho GTPase activating protein 1	roundabout guidance receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytoplasm Cytosol Plasma Membrane Cilium Cell Surface Membrane Axon Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cell Projection
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding	Protein Binding Axon Guidance Receptor Activity LRR Domain Binding Identical Protein Binding
	Biological Process	Signal Transduction Rho Protein Signal Transduction Nervous System Development Cell Migration Negative Regulation Of Cell Migration Regulation Of Synapse Assembly	Cell Migration Involved In Sprouting Angiogenesis Heart Induction Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Formation Chemotaxis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Brain Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Axon Midline Choice Point Recognition Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Cell Differentiation Negative Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Rho Protein Signal Transduction Tube Development Roundabout Signaling Pathway Aorta Development Positive Regulation Of MAPK Cascade Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Ventricular Septum Morphogenesis Negative Regulation Of Chemokine-mediated Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Pathways		Inactivation of CDC42 and RAC1 RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Activation of RAC1 Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of commissural axon pathfinding by SLIT and ROBO Inactivation of CDC42 and RAC1 Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling SLIT2:ROBO1 increases RHOA activity Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Bone erosion in rheumatoid arthritis ( 28512992) Cerebral microbleeds ( 31209788) Epithelial ovarian cancer ( 25134534) PR interval ( 32439900)	Adult body size ( 32376654) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Carotid plaque burden ( 28282560) Craniofacial microsomia ( 26853712) Diverticular disease ( 30177863) Excessive daytime sleepiness ( 27992416) Facial emotion recognition ( 28608620) Facial emotion recognition (fearful faces) ( 28608620) Femur bone mineral density x serum urate levels interaction ( 34046847) Gamma glutamyl transferase levels ( 33339817) Glomerular filtration rate in chronic kidney disease ( 26420894) HDL cholesterol levels in HIV infection ( 33109212) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Liver enzyme levels (aspartate transaminase) ( 24124411) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Nose size ( 27182965) Protein quantitative trait loci ( 18464913) Refractive error ( 32231278) Schizophrenia ( 33169155 30285260) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Takayasu arteritis ( 25604533) Visceral adipose tissue ( 26480920) Waist-hip index ( 34021172)
Interacting Genes		6 interacting genes: BMPR1B CDC42 FASLG RAC1 RHOA ROBO1	10 interacting genes: ABL1 DSCAM MAGEB6 MAPK14 ROBO2 SLIT1 SLIT2 SRGAP1 SRGAP2 TUBB3
Entrez ID		57522	6091
HPRD ID		09406	03890
Ensembl ID		ENSG00000196935	ENSG00000169855
Uniprot IDs		Q7Z6B7	Q1RMC8 Q9Y6N7
PDB IDs			2EO9 2V9Q 2V9R 2V9T 3WIH 4HLJ 5O5G 5O5I 5OPE 6A77 6A78 6A79
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Actin Filament Bundle Assembly G Protein Activity Roundabout Signaling Pathway G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cell Surface Receptor Signaling Pathway Regulation Of Stress Fiber Assembly Thioesterase Binding Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Dendrite Neuron Projection Development Establishment Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Supramolecular Fiber Organization Cellular Developmental Process Cell-cell Junction Organization Establishment Of Apical/basal Cell Polarity Positive Regulation Of Cytoskeleton Organization Anatomical Structure Morphogenesis GTP-dependent Protein Binding Polarized Epithelial Cell Differentiation Membrane Organization Regulation Of Signal Transduction Regulation Of Plasma Membrane Bounded Cell Projection Organization Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cell Projection Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Rho Protein Signal Transduction Regulation Of Cell-substrate Adhesion Establishment Of Epithelial Cell Polarity Neuron Projection Guidance Axon Guidance Cerebral Cortex Cell Migration Phagocytosis, Engulfment Regulation Of Cell Population Proliferation Postsynapse Positive Regulation Of Lamellipodium Organization Regulation Of Cell Communication Regulation Of Signaling Actin Filament Organization Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction	Regulation Of Synapse Organization Regulation Of Locomotion Neuron Projection Guidance Axon Guidance Plasma Membrane Bounded Cell Projection Organization Retinal Ganglion Cell Axon Guidance Regulation Of Cell Junction Assembly Netrin Receptor Binding Nervous System Development System Development Cell Projection Organization Apoptotic Process Involved In Luteolysis Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Regulation Of Axonogenesis Negative Regulation Of Locomotion Regulation Of Synapse Assembly Negative Regulation Of Chemotaxis Regulation Of Negative Chemotaxis Regulation Of Neuron Projection Development Regulation Of Cell Development Roundabout Binding Neuron Projection Development Regulation Of Chemotaxis Anatomical Structure Morphogenesis Netrin-activated Signaling Pathway Positive Regulation Of Axonogenesis Regulation Of Axon Extension Negative Regulation Of Synapse Assembly Regulation Of Cellular Component Organization Regulation Of Growth Axon Extension Involved In Axon Guidance Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Developmental Growth Chemotaxis Dendritic Spine Development Negative Regulation Of Synapse Organization Developmental Process Regulation Of Axon Extension Involved In Axon Guidance Pulmonary Valve Morphogenesis Locomotion Positive Regulation Of Cell Projection Organization Regulation Of Neurogenesis Circulatory System Development Growth Cone Regulation Of Cell Growth Regulation Of Multicellular Organismal Development Regulation Of Anatomical Structure Morphogenesis Regulation Of Nervous System Development Olfactory Bulb Development
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