MRTFB and KPNA4

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)

		MRTFB	KPNA4
Description		myocardin related transcription factor B	karyopherin subunit alpha 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Presynapse Postsynapse Glutamatergic Synapse	Male Germ Cell Nucleus Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Nuclear Membrane NLS-dependent Protein Nuclear Import Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Cadherin Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Muscle Organ Development Cell Differentiation Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Cell Differentiation Regulation Of Modification Of Postsynaptic Structure Positive Regulation Of MiRNA Transcription	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Gene Expression Dopamine Secretion Protein Transport Positive Regulation Of Hippo Signaling Response To Hydrogen Peroxide
Pathways			ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 32279069) Bipolar disorder ( 31043756) Malaria ( 31844061) Myeloproliferative neoplasms ( 33057200) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smooth-surface caries ( 24556642) Total cholesterol levels ( 30275531)
Interacting Genes		8 interacting genes: KDM3A KPNA4 MRTFA NCOA3 SMAD1 SMAD7 SRF SVIL	49 interacting genes: ADNP AFF2 APP CDKN1B CFAP298 CSE1L CSNK2A1 CTDSPL2 CUL4B DMTF1 DYRK1A EXO1 FAM50B GTF2IRD1 HIF1A HJURP HNRNPC HSD3B7 KAT5 KDR MAT2B MEF2C MORC3 MRTFB MTA1 NCBP3 NCOR2 NFE2L2 NKX2-5 NRIP1 NTRK3 OGT PLAA PLEKHG4B RAC1 RANBP3 RECQL RNF38 RYBP SCAND3 SPRTN SQSTM1 TGM2 TPX2 WT1 ZFTRAF1 ZMIZ2 ZNF532 ZRANB3
Entrez ID		57496	3840
HPRD ID		17577	04275
Ensembl ID		ENSG00000186260	ENSG00000186432
Uniprot IDs		I3L2S3 Q9ULH7	O00629
PDB IDs			4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB 6WX8 7JJL 7LF4 7LFC 7RFY 7RG5 8FUB 8FZM 8HKW
Enriched GO Terms of Interacting Partners?		Male Germ Cell Nucleus Heteromeric SMAD Protein Complex Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Primary MiRNA Binding Positive Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process I-SMAD Binding SMAD Protein Signal Transduction Muscle Tissue Development Smooth Muscle Cell Differentiation Positive Regulation Of Cartilage Development Regulation Of B Cell Antigen Processing And Presentation Regulation Of Cell Differentiation Positive Regulation Of Multicellular Organismal Process Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of Type I Hypersensitivity Negative Regulation Of Antibody-dependent Cellular Cytotoxicity Ureteric Bud Development Epithelium Development Mesonephric Epithelium Development Chromatin Mesonephric Tubule Development Beta-catenin Destruction Complex Disassembly Positive Regulation Of Chondrocyte Hypertrophy Serum Response Element Binding Podosome Formaldehyde Biosynthetic Process Artery Morphogenesis Negative Regulation Of Cell Population Proliferation Cellular Developmental Process Negative Regulation Of Adaptive Immune Response Low-affinity IgG Receptor Activity Tissue Development Homomeric SMAD Protein Complex Regulation Of Cartilage Development Kidney Epithelium Development Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Chondrocyte Development Bronchus Cartilage Development Lung Smooth Muscle Development Regulation Of Stem Cell Population Maintenance PDZ Domain Binding Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Cytotoxic T Cell Degranulation Regulation Of Multicellular Organismal Development	Nucleus Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Rhythmic Process Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Positive Regulation Of Developmental Process Chromatin Organization Regulation Of Developmental Growth Apoptotic Process Regulation Of MiRNA Metabolic Process Regulation Of Cellular Component Organization Regulation Of Growth Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Chromatin Regulation Of Synapse Assembly Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Programmed Cell Death Cell Death Regulation Of Cell Junction Assembly DNA Binding DNA Repair Epithelial Tube Morphogenesis Regulation Of Synapse Organization Positive Regulation Of Catabolic Process
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