MKL2 and KDM3A

Number of citations of the paper that reports this interaction (PMID 17991879)
29

Data Source:
BioGRID (pull down)

		MKL2	KDM3A
Gene Name		MKL/myocardin-like 2	lysine (K)-specific demethylase 3A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Membrane
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Actin Binding Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding Core Promoter Binding Sequence-specific DNA Binding Transcription Factor Activity Iron Ion Binding Androgen Receptor Binding Dioxygenase Activity
	Biological Process	In Utero Embryonic Development Liver Development Heart Morphogenesis Transcription, DNA-templated Muscle Organ Development Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Morphogenesis Embryonic Organ Development Cardiac Muscle Tissue Development Smooth Muscle Cell Differentiation	Chromatin Organization Transcription, DNA-templated Spermatid Nucleus Elongation Hormone-mediated Signaling Pathway Androgen Receptor Signaling Pathway Histone H3-K9 Demethylation Histone H3-K9 Dimethylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Formaldehyde Biosynthetic Process Negative Regulation Of Histone H3-K9 Methylation Oxidation-reduction Process
Pathways			Chromatin modifying enzymes Chromatin organization HDMs demethylate histones
Drugs
Diseases
GWAS		Height ( 20881960) Menarche (age at onset) ( 21102462)
Protein-Protein Interactions		6 interactors: KDM3A MKL1 SMAD1 SMAD7 SRF SVIL	6 interactors: ETV2 HIST2H3C MKL1 MKL2 MYOCD RIPK2
Entrez ID		57496	55818
HPRD ID		17577	11054
Ensembl ID		ENSG00000186260	ENSG00000115548
Uniprot IDs		B4DGT8 Q9ULH7	Q9Y4C1
PDB IDs
Enriched GO Terms of Interacting Partners?		Striated Muscle Tissue Development Muscle Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Via Serum Response Element Binding Muscle Structure Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Cardiac Muscle Tissue Development Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Smooth Muscle Cell Differentiation Artery Morphogenesis Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Artery Development Regulation Of Cell Morphogenesis BMP Signaling Pathway Developmental Process Mesoderm Formation Heart Development Mesoderm Morphogenesis RNA Metabolic Process Contractile Actin Filament Bundle Assembly Formaldehyde Biosynthetic Process Positive Regulation Of Metabolic Process Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Gene Expression Tissue Development Tissue Morphogenesis Mesonephros Development Formation Of Primary Germ Layer Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Tube Development Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Organic Substance Mesoderm Development Cardiac Chamber Development Regulation Of Cellular Component Organization Regulation Of Muscle Contraction Kidney Epithelium Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Beta-amyloid Clearance Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus	Smooth Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Muscle Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Blood Vessel Morphogenesis Muscle Structure Development Blood Vessel Development Vasculature Development Hepatic Stellate Cell Activation BMP Signaling Pathway Involved In Mesodermal Cell Fate Specification Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Metabolic Process Gene Expression Regulation Of Striated Muscle Tissue Development Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Cellular Response To Muramyl Dipeptide Negative Regulation Of Beta-amyloid Clearance Response To Interleukin-18 Positive Regulation Of Cell Differentiation Cardiovascular System Development Cardiac Muscle Tissue Development Negative Regulation Of Skeletal Muscle Cell Differentiation Fibroblast Activation Regulation Of Cell Growth By Extracellular Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation Regulation Of Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Positive Regulation Of Mesoderm Development Urinary Bladder Development Positive Regulation Of Smooth Muscle Cell Differentiation Response To Interleukin-12 Negative Regulation Of Cell Death RNA Biosynthetic Process
Tagcloud ?		arise arises conditional disassembly disrupts emt epdc epdcs epicardial epicardium lining manipulate mesothelium microvascular mkl1 mobilization motile motility mrtf mrtfa mrtfb mrtfs myocardin pericytes perinuclear shed stemming sub tracing	1alpha 2alpha 6b catalyzes cocl2 demethylase demethylases demethylation desferrioxamine dimethylation elongation experiment h3k27 h3k27me3 hif hypoxia immunoprecipitation implies indicates kdm4b kdm4c kdm6b lysine mesylate mimic modestly o2 rnai tri
Tagcloud (Difference) ?		arise arises conditional disassembly disrupts emt epdc epdcs epicardial epicardium lining manipulate mesothelium microvascular mkl1 mobilization motile motility mrtf mrtfa mrtfb mrtfs myocardin pericytes perinuclear shed stemming sub tracing	1alpha 2alpha 6b catalyzes cocl2 demethylase demethylases demethylation desferrioxamine dimethylation elongation experiment h3k27 h3k27me3 hif hypoxia immunoprecipitation implies indicates kdm4b kdm4c kdm6b lysine mesylate mimic modestly o2 rnai tri
Tagcloud (Intersection) ?