MKL2 and MKL1

Number of citations of the paper that reports this interaction (PMID 14565952)
36

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		MKL2	MKL1
Gene Name		MKL/myocardin-like 2	megakaryoblastic leukemia (translocation) 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Actin Binding Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Actin Binding Actin Monomer Binding Protein Binding Leucine Zipper Domain Binding
	Biological Process	In Utero Embryonic Development Liver Development Heart Morphogenesis Transcription, DNA-templated Muscle Organ Development Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Morphogenesis Embryonic Organ Development Cardiac Muscle Tissue Development Smooth Muscle Cell Differentiation	Transcription, DNA-templated Positive Regulation Of Transcription Via Serum Response Element Binding Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Smooth Muscle Cell Differentiation Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Height ( 20881960) Menarche (age at onset) ( 21102462)	Breast cancer ( 23535729 23535733) Breast size ( 22747683) Height ( 19570815) Treatment response for severe sepsis ( 22310353)
Protein-Protein Interactions		6 interactors: KDM3A MKL1 SMAD1 SMAD7 SRF SVIL	8 interactors: KDM3A MKL2 MVP MYOCD SMARCA4 SRF SUMO1 UBE2I
Entrez ID		57496	57591
HPRD ID		17577	10445
Ensembl ID		ENSG00000186260	ENSG00000196588
Uniprot IDs		B4DGT8 Q9ULH7	Q969V6
PDB IDs			2KVU 2KW9
Enriched GO Terms of Interacting Partners?		Striated Muscle Tissue Development Muscle Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Via Serum Response Element Binding Muscle Structure Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Cardiac Muscle Tissue Development Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Smooth Muscle Cell Differentiation Artery Morphogenesis Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Artery Development Regulation Of Cell Morphogenesis BMP Signaling Pathway Developmental Process Mesoderm Formation Heart Development Mesoderm Morphogenesis RNA Metabolic Process Contractile Actin Filament Bundle Assembly Formaldehyde Biosynthetic Process Positive Regulation Of Metabolic Process Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Gene Expression Tissue Development Tissue Morphogenesis Mesonephros Development Formation Of Primary Germ Layer Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Tube Development Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Organic Substance Mesoderm Development Cardiac Chamber Development Regulation Of Cellular Component Organization Regulation Of Muscle Contraction Kidney Epithelium Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Beta-amyloid Clearance Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus	Smooth Muscle Cell Differentiation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Beta-amyloid Clearance Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Peptidyl-lysine Modification Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Regulation Of Beta-amyloid Clearance Muscle Cell Differentiation Regulation Of DNA Binding Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Muscle Cell Myoblast Differentiation Positive Regulation Of Metabolic Process Cardioblast Differentiation Negative Regulation Of Cellular Metabolic Process Cardiac Chamber Development Heart Trabecula Formation Muscle Structure Development Blood Vessel Development Regulation Of Smooth Muscle Cell Differentiation Heart Development Vasculature Development Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Transcription, DNA-templated Cardiac Muscle Tissue Development Protein Sumoylation Positive Regulation Of Smooth Muscle Contraction Heart Trabecula Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Heart Morphogenesis Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of DNA Binding Regulation Of Binding Developmental Growth Myoblast Differentiation Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Signaling Cardiovascular System Development Stem Cell Differentiation
Tagcloud ?		arise arises conditional disassembly disrupts emt epdc epdcs epicardial epicardium lining manipulate mesothelium microvascular mkl1 mobilization motile motility mrtf mrtfa mrtfb mrtfs myocardin pericytes perinuclear shed stemming sub tracing	arise arises conditional disassembly disrupts emt epdc epdcs epicardial epicardium lining manipulate mesothelium microvascular mkl2 mobilization motile motility mrtf mrtfa mrtfb mrtfs myocardin pericytes perinuclear shed stemming sub tracing
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		arise arises conditional disassembly disrupts emt epdc epdcs epicardial epicardium lining manipulate mesothelium microvascular mkl1 mkl2 mobilization motile motility mrtf mrtfa mrtfb mrtfs myocardin pericytes perinuclear shed stemming sub tracing