MKL2

Gene Name		MKL/myocardin-like 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Actin Binding Protein Binding
	Biological Process	In Utero Embryonic Development Liver Development Heart Morphogenesis Transcription, DNA-templated Muscle Organ Development Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Morphogenesis Embryonic Organ Development Cardiac Muscle Tissue Development Smooth Muscle Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Height ( 20881960) Menarche (age at onset) ( 21102462)
Protein-protein Interactions		6 interactors: KDM3A MKL1 SMAD1 SMAD7 SRF SVIL
Entrez ID		57496
HPRD ID		17577
Ensembl ID		ENSG00000186260
Uniprot IDs		B4DGT8 Q9ULH7
PDB IDs
Enriched GO Terms of Interacting Partners?		Striated Muscle Tissue Development Muscle Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Via Serum Response Element Binding Muscle Structure Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Cardiac Muscle Tissue Development Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Smooth Muscle Cell Differentiation Artery Morphogenesis Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Artery Development Regulation Of Cell Morphogenesis BMP Signaling Pathway Developmental Process Mesoderm Formation Heart Development Mesoderm Morphogenesis RNA Metabolic Process Contractile Actin Filament Bundle Assembly Formaldehyde Biosynthetic Process Positive Regulation Of Metabolic Process Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Gene Expression Tissue Development Tissue Morphogenesis Mesonephros Development Formation Of Primary Germ Layer Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Tube Development Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Organic Substance Mesoderm Development Cardiac Chamber Development Regulation Of Cellular Component Organization Regulation Of Muscle Contraction Kidney Epithelium Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Beta-amyloid Clearance Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus
Tagcloud ?		arise arises conditional disassembly disrupts emt epdc epdcs epicardial epicardium lining manipulate mesothelium microvascular mkl1 mobilization motile motility mrtf mrtfa mrtfb mrtfs myocardin pericytes perinuclear shed stemming sub tracing