MIF4GD and HGS

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		MIF4GD	HGS
Gene Name		MIF4G domain containing	hepatocyte growth factor-regulated tyrosine kinase substrate
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm	Cytoplasm Endosome Early Endosome Cytosol Secretory Granule Early Endosome Membrane Multivesicular Body Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	RNA Binding Protein Binding Protein C-terminus Binding	Protein Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Regulation Of Translation	Protein Targeting To Lysosome Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Endosome To Lysosome Transport Membrane Invagination Positive Regulation Of Gene Expression Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of JAK-STAT Cascade Membrane Organization Protein Localization To Membrane Positive Regulation Of Exosomal Secretion
Pathways			Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS			Eye color traits ( 20463881)
Protein-Protein Interactions		10 interactors: DDX19A DDX19B EXOSC6 HDAC4 HGS HINFP PDE4DIP PPARG SVIL UBQLN4	138 interactors: ABI2 ACLY AHCYL1 APC APLP2 APP ARFIP2 ARL6IP1 ATP1A1 ATP2A2 ATXN1L BCAS2 BEGAIN BRINP3 BSG CASK CBS CCDC103 CCDC114 CCDC33 CEP55 CEP57L1 CLTC CRMP1 CSTF2 CSTF2T CTTNBP2NL DAZAP2 DCTN2 DECR1 DGCR6 DLG4 EGFR EHMT2 EPS15 ESRRG EXOC7 EXOC8 GFAP GFI1B GGA2 GKAP1 HAP1 HNRNPDL HSPA8 IL2RB IL4R ILKAP ING5 INTS4 JAKMIP2 KRT15 KRT18 KRT19 KRT31 KRT38 KRT40 KRT6A LDOC1 LINC00265 LITAF LURAP1 LYST MAGEB4 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED7 MEST MET MIF4GD MKNK1 MRFAP1L1 MTHFD1L NDC80 NEDD4 NEDD4L NF2 NMI NPAS2 NUP54 OSBPL5 P4HA3 PAK1 PEF1 PELP1 PFKM PIK3R1 PITX1 PLD3 POGZ PPP1R16A PPP1R7 PTCD3 RHOBTB3 RPS3A RSU1 SCAMP3 SCRN1 SF3B3 SMAD2 SMAD3 SMAD5 SNAP25 SNX1 SNX5 SNX7 STAM STAM2 STXBP1 SUMO1 SUN2 TADA2A TIMMDC1 TJP2 TMCC2 TOM1L1 TRAK1 TRAP1 TSG101 TUBB TUBB2A UBA1 UBA52 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 USHBP1 VMP1 VPS37A VPS37C VPS37D ZNF302
Entrez ID		57409	9146
HPRD ID		10629	05085
Ensembl ID		ENSG00000125457	ENSG00000185359
Uniprot IDs		A9UHW6 J3KSB8	O14964
PDB IDs			2D3G 3F1I 3OBQ 3ZYQ 4AVX
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Response To Metformin Response To Diuretic Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Pancreatic Stellate Cell Proliferation Protein Localization Cellular Response To Vitamin E Regulation Of Cholesterol Transporter Activity MRNA Transport RNA Transport RNA Localization Protein Transport B Cell Activation Negative Regulation Of Collagen Biosynthetic Process Negative Regulation Of Cell Proliferation Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Gene Expression Immune System Development Cellular Response To Hyperoxia Receptor Biosynthetic Process Negative Regulation Of Multicellular Organismal Metabolic Process Negative Regulation Of Sequestering Of Triglyceride Negative Regulation Of Cholesterol Storage Negative Regulation Of Glycolytic Process Peptidyl-lysine Deacetylation Response To Denervation Involved In Regulation Of Muscle Adaptation Negative Regulation Of Telomerase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity DNA Deamination Response To Inactivity Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Cellular Response To Prostaglandin E Stimulus Protein Targeting To Lysosome Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Myotube Differentiation Regulation Of Telomerase Activity Response To Low-density Lipoprotein Particle Positive Regulation Of Protein Sumoylation Positive Regulation Of Phagocytosis, Engulfment Protein Localization To Lysosome Cellular Response To Lithium Ion Positive Regulation Of Fatty Acid Oxidation White Fat Cell Differentiation Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Receptor Biosynthetic Process Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E	Establishment Of Localization In Cell Cellular Localization Viral Protein Processing Protein Localization Intracellular Transport Membrane Organization Endosomal Transport Establishment Of Protein Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Transport Regulation Of ERBB Signaling Pathway Virion Assembly Intracellular Transport Of Virus Viral Process Cellular Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Vesicle-mediated Transport Viral Life Cycle Cell Cycle Process Organelle Organization Negative Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cell Cycle Mitotic Cell Cycle Process Transport Post-Golgi Vesicle-mediated Transport Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Metabolic Process Gene Expression Cell Cycle Vesicle Organization Secretion By Cell Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Protein Transport Transcription Initiation From RNA Polymerase II Promoter Cellular Process Cellular Response To Transforming Growth Factor Beta Stimulus Posttranscriptional Regulation Of Gene Expression Secretion Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Transforming Growth Factor Beta Regulation Of Protein Catabolic Process JNK Cascade Response To Organic Substance
Tagcloud ?		bub1 cenexin cytokinesis eplin flightless flna furrow g6 gelsolin hax1 headpiece interactors kif14 kif16a kifc3 kinesin lima1 midbody odf2 overlaps predominately rhamm sh3pxd2a slip1 stard9 supervillin tks5 tnfaip1 villin	adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y
Tagcloud (Difference) ?		bub1 cenexin cytokinesis eplin flightless flna furrow g6 gelsolin hax1 headpiece interactors kif14 kif16a kifc3 kinesin lima1 midbody odf2 overlaps predominately rhamm sh3pxd2a slip1 stard9 supervillin tks5 tnfaip1 villin	adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y
Tagcloud (Intersection) ?