MIF4GD and EXOSC6

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		MIF4GD	EXOSC6
Gene Name		MIF4G domain containing	exosome component 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm	Exosome (RNase Complex) Nucleolus Cytosol
	Molecular Function	RNA Binding Protein Binding Protein C-terminus Binding	Exoribonuclease Activity Poly(A) RNA Binding
	Biological Process	Regulation Of Translation	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Isotype Switching
Pathways			Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: DDX19A DDX19B EXOSC6 HDAC4 HGS HINFP PDE4DIP PPARG SVIL UBQLN4	35 interactors: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MPP6 MRPL4 MRPS18B NDUFA13 NUDT21 PSMB1 RAB3GAP2 SKIV2L2 SRSF3 TUFM UPF2 XRN1 ZFP36
Entrez ID		57409	118460
HPRD ID		10629	12107
Ensembl ID		ENSG00000125457	ENSG00000223496
Uniprot IDs		A9UHW6 J3KSB8	Q5RKV6
PDB IDs			2NN6
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Response To Metformin Response To Diuretic Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Pancreatic Stellate Cell Proliferation Protein Localization Cellular Response To Vitamin E Regulation Of Cholesterol Transporter Activity MRNA Transport RNA Transport RNA Localization Protein Transport B Cell Activation Negative Regulation Of Collagen Biosynthetic Process Negative Regulation Of Cell Proliferation Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Gene Expression Immune System Development Cellular Response To Hyperoxia Receptor Biosynthetic Process Negative Regulation Of Multicellular Organismal Metabolic Process Negative Regulation Of Sequestering Of Triglyceride Negative Regulation Of Cholesterol Storage Negative Regulation Of Glycolytic Process Peptidyl-lysine Deacetylation Response To Denervation Involved In Regulation Of Muscle Adaptation Negative Regulation Of Telomerase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity DNA Deamination Response To Inactivity Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Cellular Response To Prostaglandin E Stimulus Protein Targeting To Lysosome Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Myotube Differentiation Regulation Of Telomerase Activity Response To Low-density Lipoprotein Particle Positive Regulation Of Protein Sumoylation Positive Regulation Of Phagocytosis, Engulfment Protein Localization To Lysosome Cellular Response To Lithium Ion Positive Regulation Of Fatty Acid Oxidation White Fat Cell Differentiation Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Receptor Biosynthetic Process Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Metabolic Process MRNA Catabolic Process RNA Catabolic Process RRNA Metabolic Process Aromatic Compound Catabolic Process Ribosome Biogenesis RRNA Processing Ribonucleoprotein Complex Biogenesis Gene Expression Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic NcRNA Metabolic Process Nuclear MRNA Surveillance RNA Metabolic Process RNA Surveillance RRNA Catabolic Process Maturation Of 5.8S RRNA RNA Phosphodiester Bond Hydrolysis Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Catabolic Process Nucleobase-containing Compound Metabolic Process Histone MRNA Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Processing Cellular Metabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Histone MRNA Metabolic Process MRNA Processing RNA Splicing Metabolic Process RNA 3'-end Processing RNA Splicing, Via Transesterification Reactions RNA Localization DNA Deamination Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Intracellular MRNA Localization Mitochondrial Translational Elongation MRNA 3'-end Processing Mitochondrion Organization Mitochondrial Translation MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Tagcloud ?		bub1 cenexin cytokinesis eplin flightless flna furrow g6 gelsolin hax1 headpiece interactors kif14 kif16a kifc3 kinesin lima1 midbody odf2 overlaps predominately rhamm sh3pxd2a slip1 stard9 supervillin tks5 tnfaip1 villin
Tagcloud (Difference) ?		bub1 cenexin cytokinesis eplin flightless flna furrow g6 gelsolin hax1 headpiece interactors kif14 kif16a kifc3 kinesin lima1 midbody odf2 overlaps predominately rhamm sh3pxd2a slip1 stard9 supervillin tks5 tnfaip1 villin
Tagcloud (Intersection) ?