MLLT1 and AFF1

Number of citations of the paper that reports this interaction (PMID 15856011)
23

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		MLLT1	AFF1
Gene Name		myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	AF4/FMR2 family, member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Transcription Elongation Factor Complex	Transcription Elongation Factor Complex
	Molecular Function	DNA Binding Protein Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity	Positive Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033) Bulimia nervosa ( 23568457) Systemic lupus erythematosus ( 22291604) Triglycerides ( 20864672 20686565)
Protein-Protein Interactions		9 interactors: AFF1 AFF4 ARID1A CBX8 HIST1H1B HIST3H3 MLLT10 PAF1 WDR5	7 interactors: HIST3H3 MLLT1 MLLT3 NT5E SIAH1 SIAH2 SMAD9
Entrez ID		4298	4299
HPRD ID		15933	08871
Ensembl ID			ENSG00000172493
Uniprot IDs		Q03111	P51825 Q14C88
PDB IDs			2LM0
Enriched GO Terms of Interacting Partners?		Chromosome Organization Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromatin Modification Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Histone Ubiquitination Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Nucleobase-containing Compound Metabolic Process Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone Modification RNA Metabolic Process Nucleosome Mobilization Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Optic Cup Formation Involved In Camera-type Eye Development Regulation Of Protein Stability Nucleosome Organization Chromatin Assembly Or Disassembly Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Establishment Of Protein Localization To Chromatin Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Optic Cup Morphogenesis Involved In Camera-type Eye Development Glucocorticoid Receptor Signaling Pathway Histone H2B Ubiquitination Biosynthetic Process	Adenosine Biosynthetic Process AMP Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Purine Nucleoside Monophosphate Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Mullerian Duct Regression Cellular Metabolic Process Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Non-canonical Wnt Signaling Pathway Purine Ribonucleoside Catabolic Process Nucleobase-containing Compound Metabolic Process AMP Metabolic Process Adenosine Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Segment Specification Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Axon Guidance Anatomical Structure Regression Pyrimidine Nucleoside Catabolic Process Cellular Nitrogen Compound Metabolic Process Protein Destabilization Purine Ribonucleotide Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nitrogen Compound Metabolic Process
Tagcloud ?		abl1 aff1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mllt3 mllt4 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16	abl1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mll mllt1 mllt10 mllt3 mllt4 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		abl1 aff1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mll mllt1 mllt10 mllt3 mllt4 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16