MLLT1 and PAF1

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (affinity chromatography technology, biochemical, pull down, affinity chromatography technology)

		MLLT1	PAF1
Description		MLLT1 super elongation complex subunit	PAF1 component of Paf1/RNA polymerase II complex
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytosol Transcription Elongation Factor Complex	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Membrane Cdc73/Paf1 Complex
	Molecular Function	Chromatin Binding Protein Binding	RNA Polymerase II Complex Binding Chromatin Binding Protein Binding
	Biological Process	Positive Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Commitment Transcription Elongation By RNA Polymerase II Wnt Signaling Pathway Stem Cell Population Maintenance MRNA 3'-end Processing Protein Localization To Nucleus Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288)
Interacting Genes		13 interacting genes: AFF1 AFF4 ALKBH4 ARID1A BMI1 CBX8 FXR1 H1-5 H3-4 MLLT10 PAF1 WDR5 YIF1A	17 interacting genes: CEBPA ENO1 ERCC6 FXR2 H1-2 H3C1 HSPB1 KAT8 KMT2A MLLT1 MSL1 MSL2 MSL3 RNF20 SUMO2 TCEA1 TULP3
Entrez ID		4298	54623
HPRD ID		15933	10140
Ensembl ID		ENSG00000130382	ENSG00000006712
Uniprot IDs		Q03111	Q8N7H5
PDB IDs		5J9S 6HPW 6HPX 6HPY 6HPZ 6HQ0 6HT0 6HT1 6T1I 6T1J 6T1L 6T1M 6T1N 6T1O 7B0T 7B10 7E74 7E7A 7E7C 7X88 7X8B 7X8F 7X8G 8PJI	4M6T 5ZYQ 6GMH 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH2
Enriched GO Terms of Interacting Partners?		Heterochromatin Chromatin Organization Regulation Of Macromolecule Biosynthetic Process Chromatin Remodeling Regulation Of Gene Expression Super Elongation Complex Positive Regulation Of Gene Expression, Epigenetic Ubiquitin-protein Transferase Activator Activity Nucleus Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process PRC1 Complex Regulation Of Metabolic Process Transcription Elongation Factor Complex Nucleosome Organization Positive Regulation Of Macromolecule Metabolic Process PcG Protein Complex Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleosome Binding Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Histone H3Q5ser Reader Activity DNA N6-methyladenine Demethylase Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Euchromatin Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Adaxial/abaxial Pattern Formation Histone H3K4me1 Reader Activity Cleavage Furrow Ingression Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Structural Constituent Of Chromatin Positive Regulation Of Macromolecule Biosynthetic Process RING-like Zinc Finger Domain Binding Rostrocaudal Neural Tube Patterning Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Spermatid Development	MSL Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Chromatin Organization Nucleus Chromatin Remodeling Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Chromatin Binding Epigenetic Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation DNA Binding Positive Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Transcription Elongation Factor Complex Nucleolus NuA4 Histone Acetyltransferase Complex MLL1 Complex Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Chromosome Protein Homodimerization Activity RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Protein Kinase C Signaling Histone H2B Ubiquitin Ligase Activity Histone H2B C-terminal K Residue Ubiquitin Ligase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Proteolysis Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Protein Metabolic Process DNA-templated Transcription Elongation Positive Regulation Of Gene Expression, Epigenetic Cerebellar Purkinje Cell Layer Maturation Response To Vitamin B2 C/EBP Complex
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