MLLT1 and AFF4

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (biochemical, affinity chromatography technology, affinity chromatography technology, biochemical)
HPRD (two hybrid)

		MLLT1	AFF4
Description		MLLT1 super elongation complex subunit	ALF transcription elongation factor 4
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytosol Transcription Elongation Factor Complex	Euchromatin Fibrillar Center Nucleus Nucleoplasm Chromosome Transcription Elongation Factor Complex Nuclear Body Super Elongation Complex
	Molecular Function	Chromatin Binding Protein Binding	Protein Binding
	Biological Process	Positive Regulation Of DNA-templated Transcription	Spermatid Development Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288)	A body shape index ( 34021172) Asthma ( 31619474) Estimated glomerular filtration rate ( 31152163) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		13 interacting genes: AFF1 AFF4 ALKBH4 ARID1A BMI1 CBX8 FXR1 H1-5 H3-4 MLLT10 PAF1 WDR5 YIF1A	10 interacting genes: AP2B1 BTG3 CCNT1 CDK9 GOLGA2 LRRK2 MLLT1 SIAH1 SPP1 TRAF2
Entrez ID		4298	27125
HPRD ID		15933	09187
Ensembl ID		ENSG00000130382	ENSG00000072364
Uniprot IDs		Q03111	Q9UHB7
PDB IDs		5J9S 6HPW 6HPX 6HPY 6HPZ 6HQ0 6HT0 6HT1 6T1I 6T1J 6T1L 6T1M 6T1N 6T1O 7B0T 7B10 7E74 7E7A 7E7C 7X88 7X8B 7X8F 7X8G 8PJI	4IMY 4OGR 4OR5 5JW9 5L1Z 6CYT 6K7P 6KN5 6R80
Enriched GO Terms of Interacting Partners?		Heterochromatin Chromatin Organization Regulation Of Macromolecule Biosynthetic Process Chromatin Remodeling Regulation Of Gene Expression Super Elongation Complex Positive Regulation Of Gene Expression, Epigenetic Ubiquitin-protein Transferase Activator Activity Nucleus Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process PRC1 Complex Regulation Of Metabolic Process Transcription Elongation Factor Complex Nucleosome Organization Positive Regulation Of Macromolecule Metabolic Process PcG Protein Complex Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleosome Binding Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Histone H3Q5ser Reader Activity DNA N6-methyladenine Demethylase Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Euchromatin Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Adaxial/abaxial Pattern Formation Histone H3K4me1 Reader Activity Cleavage Furrow Ingression Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Structural Constituent Of Chromatin Positive Regulation Of Macromolecule Biosynthetic Process RING-like Zinc Finger Domain Binding Rostrocaudal Neural Tube Patterning Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Spermatid Development	P-TEFb Complex 7SK SnRNA Binding Cyclin/CDK Positive Transcription Elongation Factor Complex SnRNA Binding Host-mediated Activation Of Viral Transcription Transcription Elongation Factor Complex Protein Kinase Binding Host-mediated Perturbation Of Viral Transcription Positive Regulation Of Macromolecule Biosynthetic Process Clathrin Binding Positive Regulation Of Biosynthetic Process Host-mediated Activation Of Viral Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury TORC2 Complex Disassembly Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Metabolic Process Host-mediated Perturbation Of Viral Process Positive Regulation Of Protein Modification Process Negative Regulation Of Catabolic Process Positive Regulation Of Estradiol Secretion TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Protein Modification Process Regulation Of Apoptotic Signaling Pathway Regulation Of Transcription Elongation By RNA Polymerase II Cytoplasmic Side Of Plasma Membrane Regulation Of DNA-templated Transcription Elongation Host-mediated Perturbation Of Symbiont Process Positive Regulation Of Protein Localization To Chromatin Negative Regulation Of Autophagy Canonical Wnt Signaling Pathway Regulation Of Estradiol Secretion Positive Regulation Of Protein Autoubiquitination Response To Curcumin Signal Sequence Binding Chromatin Binding Regulation Of Protein Serine/threonine Kinase Activity
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