MLLT1 and AFF4

Number of citations of the paper that reports this interaction (PMID 21729782)
60

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (two hybrid)

		MLLT1	AFF4
Gene Name		myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	AF4/FMR2 family, member 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Transcription Elongation Factor Complex	Nucleus Nucleoplasm Nucleolus Mitochondrion Transcription Elongation Factor Complex Transcriptionally Active Chromatin
	Molecular Function	DNA Binding Protein Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Spermatid Development
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: AFF1 AFF4 ARID1A CBX8 HIST1H1B HIST3H3 MLLT10 PAF1 WDR5	9 interactors: AP2B1 CCNT1 CDK9 GOLGA2 MLLT1 MTUS2 SIAH1 SPP1 TRAF2
Entrez ID		4298	27125
HPRD ID		15933	09187
Ensembl ID			ENSG00000072364
Uniprot IDs		Q03111	Q9UHB7
PDB IDs			4IMY
Enriched GO Terms of Interacting Partners?		Chromosome Organization Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromatin Modification Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Histone Ubiquitination Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Nucleobase-containing Compound Metabolic Process Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone Modification RNA Metabolic Process Nucleosome Mobilization Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Optic Cup Formation Involved In Camera-type Eye Development Regulation Of Protein Stability Nucleosome Organization Chromatin Assembly Or Disassembly Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Establishment Of Protein Localization To Chromatin Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Optic Cup Morphogenesis Involved In Camera-type Eye Development Glucocorticoid Receptor Signaling Pathway Histone H2B Ubiquitination Biosynthetic Process	Positive Regulation Of Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Replication Fork Arrest Response To Organic Substance Viral Process Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Growth Factor Stimulus Chemotaxis Response To Growth Factor Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Binding Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Protein Kinase Activity Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Collateral Sprouting Negative Regulation Of Glial Cell Apoptotic Process Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Axon Regeneration Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Binding Positive Regulation Of Protein Homodimerization Activity Regulation Of Protein Metabolic Process Cellular Response To Nitric Oxide Regulation Of Protein Phosphorylation Regulation Of Immunoglobulin Secretion Response To Nitric Oxide Positive Regulation Of Bone Resorption Regulation Of Axon Regeneration Protein Homotrimerization Positive Regulation Of T Cell Cytokine Production Positive Regulation Of Cell Adhesion Regulation Of Protein Homodimerization Activity Locomotion Axon Guidance Cellular Response To Reactive Nitrogen Species Regulation Of Phosphorylation Negative Regulation Of Cell Cycle Arrest Cell Cycle
Tagcloud ?		abl1 aff1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mllt3 mllt4 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16	af4 af9 arise cofactor complexes cyclint1 defined definitive dot1 eaf1 eaf2 ell elongation functionally fusion immortalization interactions k79 leukemias leukemogenesis mechanistic methyltransferase mll overlapping partners reconstitution reside subcomplexes tefb
Tagcloud (Difference) ?		abl1 aff1 cbfb cryptic cytogenetics dek etv6 fifteen inv mllt3 mllt4 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16	af4 af9 arise cofactor complexes cyclint1 defined definitive dot1 eaf1 eaf2 elongation functionally fusion immortalization interactions k79 leukemias leukemogenesis mechanistic methyltransferase overlapping partners reconstitution reside subcomplexes tefb
Tagcloud (Intersection) ?		ell mll