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THAP11 and SIN3A
Number of citations of the paper that reports this interaction (PubMedID
18585351
)
54
Data Source:
HPRD
(in vitro)
THAP11
SIN3A
Description
THAP domain containing 11
SIN3 transcription regulator family member A
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Histone Deacetylase Complex
Kinetochore
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Chromosome
Nucleolus
Transcription Repressor Complex
Protein-containing Complex
Sin3-type Complex
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Zinc Ion Binding
Metal Ion Binding
DNA Binding
Chromatin Binding
Transcription Corepressor Activity
RNA Binding
Protein Binding
Protein-containing Complex Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Transcription Regulator Inhibitor Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Cell Population Proliferation
Electron Transport Chain
Neuron Differentiation
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Mitochondrial Transcription
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Hematopoietic Progenitor Cell Differentiation
DNA Replication
Regulation Of DNA-templated Transcription
Intracellular Protein Localization
Regulation Of Hormone Levels
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cerebral Cortex Neuron Differentiation
Negative Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Axon Extension
Heterochromatin Formation
Negative Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Positive Regulation Of Neuron Differentiation
Negative Regulation Of DNA-templated Transcription
Rhythmic Process
Response To Methylglyoxal
Type I Interferon-mediated Signaling Pathway
Cellular Response To Glucose Stimulus
Cellular Response To Tert-butyl Hydroperoxide
Negative Regulation Of Protein Localization To Nucleus
Negative Regulation Of Stem Cell Population Maintenance
Positive Regulation Of Stem Cell Population Maintenance
Cellular Response To Dopamine
Pathways
SUMOylation of transcription cofactors
Regulation of lipid metabolism by PPARalpha
NoRC negatively regulates rRNA expression
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Loss of MECP2 binding ability to 5mC-DNA
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
STAT3 nuclear events downstream of ALK signaling
Cytoprotection by HMOX1
Regulation of MITF-M-dependent genes involved in apoptosis
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
27863252
)
Schizophrenia (
25056061
29483656
)
Caffeine consumption from tea (
33287642
)
Estimated glomerular filtration rate (
31152163
)
Height (
20189936
)
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
)
Sudden cardiac arrest (
21658281
)
Type 2 diabetes (
32499647
)
Interacting Genes
21 interacting genes:
BBLN
CASP3
CEBPA
CFTR
ECT2
HCFC1
HDAC1
HDAC3
HEMGN
L3MBTL2
LRRC45
MCPH1
NUTF2
PFDN6
PSMC5
SIN3A
SLX1B
SRSF11
THAP7
TPX2
VPS52
101 interacting genes:
ARID4A
ARID4B
ATM
BCL11A
BCL6
BCL6B
BHLHE40
BNIP2
BRMS1
BRMS1L
CBFA2T2
CEBPA
CIAO2A
COPS2
CTBP1
CTCF
CUL4B
CYTOR
DACH1
DDB1
DDX20
DHX30
DMRTC1B
ETV6
FOXK2
H3-4
HBP1
HCFC1
HDAC1
HDAC2
HDAC7
HDAC9
HEY2
HTT
IKZF1
IKZF4
ING1
IRF5
KLF10
KLF11
KLF13
KLF16
KLF9
LRCH4
MAD1L1
MBD2
MBD4
MECP2
MEN1
MNT
MORF4L2
MXD1
MXD4
MXI1
MYB
NDRG4
NFKB1
NFKB2
NR2E3
OGT
PA2G4
PBX3
PHB1
PHF12
PML
PRMT5
PTEN
PTMA
RBBP4
RBBP7
RBP1
RBPJ
REL
RELA
RELB
RLIM
RUNX1T1
SAP18
SAP30
SETDB1
SFPQ
SH3GLB1
SKI
SMAD3
SMARCA4
SMARCC1
SMARCE1
SNW1
SPI1
STAT3
SUMO2
SYT1
TAL1
TFCP2
TGIF1
THAP11
TOPORS
TP53
TRIM28
TSN
ZBTB16
Entrez ID
57215
25942
HPRD ID
11629
09690
Ensembl ID
ENSG00000168286
ENSG00000169375
Uniprot IDs
Q96EK4
Q96ST3
PDB IDs
2LAU
5AJS
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
DNA-binding Transcription Factor Binding
Negative Regulation Of RNA Biosynthetic Process
Protein Decrotonylase Activity
Histone Decrotonylase Activity
Protein Lysine Delactylase Activity
Negative Regulation Of Metabolic Process
Regulation Of Cell Cycle
Negative Regulation Of RNA Metabolic Process
Chromatin Binding
Histone Deacetylase Binding
Histone Deacetylase Complex
Transcription Corepressor Binding
Transcription Repressor Complex
Histone Deacetylase Activity, Hydrolytic Mechanism
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Deacetylation
Protein Lysine Deacetylase Activity
General Transcription Initiation Factor Binding
Response To Ketone
Negative Regulation Of Biosynthetic Process
Chromatin DNA Binding
Rhythmic Process
Protein-containing Complex
Negative Regulation Of Myotube Differentiation
Histone Deacetylase Activity
Positive Regulation Of Protein Metabolic Process
Regulation Of Primary Metabolic Process
Nucleus
Sin3-type Complex
Chromatin Organization
Negative Regulation Of Stem Cell Population Maintenance
Macromolecule Deacylation
Microtubule Cytoskeleton Organization Involved In Mitosis
Response To Glucocorticoid
Mitotic Spindle
Heterochromatin Formation
NF-kappaB Binding
Cellular Developmental Process
Regulation Of Protein Stability
Regulation Of Macromolecule Metabolic Process
Cell Differentiation
Response To Corticosteroid
RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding
Intracellularly ATP-gated Chloride Channel Activity
Positive Regulation Of Voltage-gated Chloride Channel Activity
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
Nucleoplasm
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Nucleus
Regulation Of Primary Metabolic Process
DNA Binding
Regulation Of Macromolecule Metabolic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Chromatin
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
DNA-binding Transcription Factor Activity
Sin3-type Complex
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Chromatin Organization
Positive Regulation Of Stem Cell Population Maintenance
Regulation Of Stem Cell Population Maintenance
Chromatin Binding
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Developmental Process
Negative Regulation Of Stem Cell Population Maintenance
Positive Regulation Of Metabolic Process
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Chromatin Remodeling
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Binding
Transcription Repressor Complex
Epigenetic Regulation Of Gene Expression
Transcription Corepressor Activity
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Developmental Process
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