THAP11 and THAP7

Number of citations of the paper that reports this interaction (PubMedID 18585351)
54

Data Source:
HPRD (in vitro)

		THAP11	THAP7
Description		THAP domain containing 11	THAP domain containing 7
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Speck Nuclear Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Transcription Corepressor Binding DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Histone Deacetylase Binding Metal Ion Binding C2H2 Zinc Finger Domain Binding Histone H4 Reader Activity General Transcription Initiation Factor Binding Histone Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Electron Transport Chain Neuron Differentiation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Mitochondrial Transcription	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS		Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252) Schizophrenia ( 25056061 29483656)
Interacting Genes		21 interacting genes: BBLN CASP3 CEBPA CFTR ECT2 HCFC1 HDAC1 HDAC3 HEMGN L3MBTL2 LRRC45 MCPH1 NUTF2 PFDN6 PSMC5 SIN3A SLX1B SRSF11 THAP7 TPX2 VPS52	63 interacting genes: ANKRD28 APP CCDC136 CCDC85B CCNDBP1 CDC37 CYSRT1 DESI2 DVL3 EFEMP2 EHMT2 FBXO7 FHL3 FSD2 GABARAPL1 GNAI1 GOLGA2 GOLGA6L9 H3C1 H4C1 HCFC1 HDAC3 HOXA1 KRT27 KRT31 KRT34 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP17-1 KRTAP4-12 LDOC1 LNX1 LURAP1 LZTS2 MAGOHB MAP1LC3B MCC MDFI MID2 MTUS2 NBPF19 NOTCH2NLA NTAQ1 PELI2 PHC2 PHF19 PICK1 PIN1 PNMA2 PPP3CC SET TAF1B TFIP11 THAP11 TLE5 TPM3 TRAF1 TRAF2 TRAF5 ZDHHC17 ZRANB1
Entrez ID		57215	80764
HPRD ID		11629	15500
Ensembl ID		ENSG00000168286	ENSG00000184436
Uniprot IDs		Q96EK4	Q9BT49
PDB IDs		2LAU 5AJS
Enriched GO Terms of Interacting Partners?		Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding Negative Regulation Of RNA Biosynthetic Process Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Lysine Delactylase Activity Negative Regulation Of Metabolic Process Regulation Of Cell Cycle Negative Regulation Of RNA Metabolic Process Chromatin Binding Histone Deacetylase Binding Histone Deacetylase Complex Transcription Corepressor Binding Transcription Repressor Complex Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Protein Deacetylation Protein Lysine Deacetylase Activity General Transcription Initiation Factor Binding Response To Ketone Negative Regulation Of Biosynthetic Process Chromatin DNA Binding Rhythmic Process Protein-containing Complex Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Primary Metabolic Process Nucleus Sin3-type Complex Chromatin Organization Negative Regulation Of Stem Cell Population Maintenance Macromolecule Deacylation Microtubule Cytoskeleton Organization Involved In Mitosis Response To Glucocorticoid Mitotic Spindle Heterochromatin Formation NF-kappaB Binding Cellular Developmental Process Regulation Of Protein Stability Regulation Of Macromolecule Metabolic Process Cell Differentiation Response To Corticosteroid RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity	Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Thioesterase Binding Protein Binding Regulation Of Wnt Signaling Pathway Regulation Of JNK Cascade Regulation Of Toll Signaling Pathway Cytosol Intermediate Filament Organization Protein-containing Complex Disassembly Tumor Necrosis Factor Receptor Binding Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Wnt Signaling Pathway Supramolecular Fiber Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Identical Protein Binding Protein Serine/threonine Phosphatase Complex CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cellular Response To Nitrogen Starvation Cytoskeleton CD40 Receptor Complex
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