USP33 and CCP110

Number of citations of the paper that reports this interaction (PMID 23486064)
11

Data Source:
BioGRID (enzymatic study)

		USP33	CCP110
Gene Name		ubiquitin specific peptidase 33	centriolar coiled coil protein 110kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Autophagic Vacuole Golgi Apparatus Centrosome VCB Complex Cell Body Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm	Centrosome Centriole Cytosol Protein Complex
	Molecular Function	G-protein Coupled Receptor Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Ral GTPase Binding Ubiquitin Binding	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Endocytosis Axon Guidance Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Starvation Regulation Of Autophagy Cell Migration Protein Deubiquitination Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Centrosome Duplication Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Centriole Replication Cell Projection Organization Regulation Of Cytokinesis Centrosome Duplication
Pathways			Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ARRB2 CCP110 DDX56 DIO2 EIF6 SELENBP1 TCEB1 TRIM54 TRIM63 UBC USP15 USP21 USP28 VHL	12 interactors: AKAP9 CALM1 CALM3 CDK1 CDK2 CEP97 CETN1 CETN2 PCNT PNMA1 TFIP11 USP33
Entrez ID		23032	9738
HPRD ID		10297	10848
Ensembl ID		ENSG00000077254	ENSG00000103540
Uniprot IDs		Q8TEY7	B4DTZ1 O43303
PDB IDs		2UZG
Enriched GO Terms of Interacting Partners?		Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Proteolysis Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Response To Abiotic Stimulus Cellular Protein Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Proteolysis Protein Deubiquitination Cellular Response To Oxygen Levels Protein Modification By Small Protein Removal Histone Deubiquitination Regulation Of Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Protein Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Proteasomal Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Hypoxia Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Metabolic Process Cellular Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Histone H2B Conserved C-terminal Lysine Deubiquitination Thyroid Hormone Catabolic Process Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Protein Ubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Signal Transduction By P53 Class Mediator G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Gene Expression	G2/M Transition Of Mitotic Cell Cycle Centrosome Cycle Organelle Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Centrosome Organization Cell Cycle Process Microtubule Organizing Center Organization Mitotic Cell Cycle Process Centrosome Duplication Mitotic Cell Cycle Cell Cycle Microtubule Cytoskeleton Organization Response To Amine Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cytokinesis Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Heart Rate Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Ion Transmembrane Transport Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Mitotic Nuclear Division Vascular Endothelial Growth Factor Receptor Signaling Pathway Detection Of Calcium Ion Positive Regulation Of Transport Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Microtubule-based Process Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Glycogen Catabolic Process Negative Regulation Of Peptidyl-threonine Phosphorylation Cell Division Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Regulation Of Intracellular Transport Response To Stress Regulation Of Cell Cycle Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Response To Inorganic Substance
Tagcloud ?		autophagocytosis autophagosome beclin deubiquitylase deubiquitylated deubiquitylation driving effector employs engaging exo84 exocyst facilitating gtp gtpase lys molecularly nutrient ral ralb relocalization sec5 starvation sterically switch tbk1 tunes turns ubiquitylation
Tagcloud (Difference) ?		autophagocytosis autophagosome beclin deubiquitylase deubiquitylated deubiquitylation driving effector employs engaging exo84 exocyst facilitating gtp gtpase lys molecularly nutrient ral ralb relocalization sec5 starvation sterically switch tbk1 tunes turns ubiquitylation
Tagcloud (Intersection) ?