USP33 and USP21

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		USP33	USP21
Gene Name		ubiquitin specific peptidase 33	ubiquitin specific peptidase 21
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Autophagic Vacuole Golgi Apparatus Centrosome VCB Complex Cell Body Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm	Cellular_component Nucleoplasm Cytoplasm Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Ral GTPase Binding Ubiquitin Binding	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Endocytosis Axon Guidance Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Starvation Regulation Of Autophagy Cell Migration Protein Deubiquitination Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Centrosome Duplication Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Histone Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Proteasomal Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ARRB2 CCP110 DDX56 DIO2 EIF6 SELENBP1 TCEB1 TRIM54 TRIM63 UBC USP15 USP21 USP28 VHL	43 interactors: ATXN3 BAP1 CBL CBLC DTX3 ESPL1 EXOSC10 HIST2H2AA3 ISG15 JOSD1 KRT40 LRSAM1 OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 STAMBP TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 YOD1
Entrez ID		23032	27005
HPRD ID		10297	05291
Ensembl ID		ENSG00000077254	ENSG00000143258
Uniprot IDs		Q8TEY7	Q9UK80
PDB IDs		2UZG	2Y5B 3I3T 3MTN
Enriched GO Terms of Interacting Partners?		Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Proteolysis Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Response To Abiotic Stimulus Cellular Protein Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Proteolysis Protein Deubiquitination Cellular Response To Oxygen Levels Protein Modification By Small Protein Removal Histone Deubiquitination Regulation Of Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Protein Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Proteasomal Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Hypoxia Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Metabolic Process Cellular Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Histone H2B Conserved C-terminal Lysine Deubiquitination Thyroid Hormone Catabolic Process Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Protein Ubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Signal Transduction By P53 Class Mediator G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Gene Expression	Protein Modification By Small Protein Removal Protein Deubiquitination Proteolysis Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Protein Metabolic Process Cellular Protein Metabolic Process Protein K48-linked Deubiquitination Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Regulation Of Protein Catabolic Process Regulation Of Proteolysis Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Histone Deubiquitination Metabolic Process Monoubiquitinated Protein Deubiquitination Protein Polyubiquitination Regulation Of Protein Ubiquitination Regulation Of Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Communication Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K63-linked Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Viral Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Protein K11-linked Deubiquitination Regulation Of Cellular Process Signaling Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Viral Entry Into Host Cell
Tagcloud ?		autophagocytosis autophagosome beclin deubiquitylase deubiquitylated deubiquitylation driving effector employs engaging exo84 exocyst facilitating gtp gtpase lys molecularly nutrient ral ralb relocalization sec5 starvation sterically switch tbk1 tunes turns ubiquitylation	4alpha chromatin concomitant deacetylase deacetylation details determines dimethylation dysregulation glycogen grb14 hepatocyte hnf hypothesis interpretation latter lys14 lys4 lys9 mediator nucleosomes pea15 ped proximal remodelling represses scaffold serves silencing
Tagcloud (Difference) ?		autophagocytosis autophagosome beclin deubiquitylase deubiquitylated deubiquitylation driving effector employs engaging exo84 exocyst facilitating gtp gtpase lys molecularly nutrient ral ralb relocalization sec5 starvation sterically switch tbk1 tunes turns ubiquitylation	4alpha chromatin concomitant deacetylase deacetylation details determines dimethylation dysregulation glycogen grb14 hepatocyte hnf hypothesis interpretation latter lys14 lys4 lys9 mediator nucleosomes pea15 ped proximal remodelling represses scaffold serves silencing
Tagcloud (Intersection) ?