USP33 and DIO2

Number of citations of the paper that reports this interaction (PubMedID 12865408)
31

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		USP33	DIO2
Description		ubiquitin specific peptidase 33	iodothyronine deiodinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Focal Adhesion VCB Complex Neuronal Cell Body Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Small GTPase Binding Ubiquitin Binding Metal Ion Binding	Thyroxine 5'-deiodinase Activity Selenium Binding Oxidoreductase Activity Ubiquitin Protein Ligase Binding Thyroxine 5-deiodinase Activity
	Biological Process	Proteolysis Ubiquitin-dependent Protein Catabolic Process Endocytosis Nervous System Development Axon Guidance Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Migration Protein Deubiquitination Protein Stabilization Centrosome Duplication Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Positive Regulation Of Autophagosome Assembly	Selenocysteine Incorporation Thyroid Hormone Generation Response To Lipopolysaccharide Thyroid Hormone Metabolic Process Thyroid Hormone Catabolic Process Hormone Biosynthetic Process Positive Regulation Of Cold-induced Thermogenesis
Pathways		Ub-specific processing proteases Regulation of expression of SLITs and ROBOs	Regulation of thyroid hormone activity Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Drugs
Diseases
GWAS		Adult body size ( 32376654) Post bronchodilator FEV1 ( 26634245)	Free thyroxine concentration ( 30367059) Metabolite levels ( 23823483) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Rosacea symptom severity ( 29771307)
Interacting Genes		17 interacting genes: CCP110 CHRM5 DDX56 DIO2 DSCR9 EIF6 ELOC PRKN SELENBP1 SNCA TRIM54 TRIM63 UBC USP15 USP21 USP28 VHL	6 interacting genes: MARCHF6 UBE2G1 UBE2J1 USP20 USP33 WSB1
Entrez ID		23032	1734
HPRD ID		10297	09027
Ensembl ID		ENSG00000077254	ENSG00000211448
Uniprot IDs		Q8TEY7	A8K845 Q92813
PDB IDs		2UZG
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Dopamine Transport Monoamine Transport Protein Deubiquitination Amyloid Fibril Formation Protein Modification By Small Protein Removal Target-directed MiRNA Degradation Elongin Complex Protein Modification Process Dopamine Uptake Involved In Synaptic Transmission Protein Ubiquitination Protein Metabolic Process Selenium Binding Protein Modification By Small Protein Conjugation Catecholamine Uptake Dopamine Uptake Regulation Of ATP Metabolic Process MiRNA Catabolic Process Phenol-containing Compound Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Proteolysis Synaptic Transmission, Dopaminergic Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing Cul5-RING Ubiquitin Ligase Complex Cysteine-type Deubiquitinase Activity Macromolecule Metabolic Process Cul2-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Neurotransmitter Reuptake Regulation Of Neurotransmitter Uptake Regulation Of Dopamine Metabolic Process Phospholipase Binding Regulation Of Phosphorus Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Dopamine Secretion MiRNA Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of MiRNA-mediated Gene Silencing Cysteine-type Peptidase Activity Deubiquitinase Activity Post-transcriptional Gene Silencing Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Post-transcriptional Gene Silencing Neurotransmitter Uptake Regulation Of Synaptic Vesicle Recycling Cytosol Dopamine Metabolic Process Regulation Of Protein Stability	Post-translational Protein Modification Protein Modification Process Protein Polyubiquitination Proteolysis Protein Ubiquitination Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Cysteine-type Endopeptidase Activity G Protein-coupled Receptor Binding ER Ubiquitin Ligase Complex Proteasomal Protein Catabolic Process Cysteine-type Deubiquitinase Activity ERAD Pathway Macromolecule Metabolic Process Protein Deubiquitination Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Removal Protein Aggregate Center Assembly Protein Catabolic Process Cysteine-type Peptidase Activity VCB Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagy Catabolic Process Hrd1p Ubiquitin Ligase Complex Response To Endoplasmic Reticulum Stress Negative Regulation Of Cholesterol Biosynthetic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Cholesterol Metabolic Process Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Glycoprotein Metabolic Process Negative Regulation Of Protein Exit From Endoplasmic Reticulum Ubiquitin Protein Ligase Binding Regulation Of Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Mannose Trimming Protein Alpha-1,2-demannosylation Protein K27-linked Ubiquitination Ubiquitin Protein Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin-specific Protease Binding Regulation Of Autophagy Centrosome Duplication Protein Deglycosylation
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