RTN4 and TUBA4A

Number of citations of the paper that reports this interaction (PMID 12377379)
4

Data Source:
HPRD (in vivo)

		RTN4	TUBA4A
Gene Name		reticulon 4	tubulin, alpha 4a
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nuclear Envelope Endoplasmic Reticulum Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Cell Projection Neuronal Cell Body Extracellular Vesicular Exosome	Extracellular Region Cytosol Microtubule Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Poly(A) RNA Binding	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding
	Biological Process	Angiogenesis Apoptotic Process Axonal Fasciculation Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of Cell Growth Regulation Of Cell Migration Negative Regulation Of Axon Extension Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Cardiac Epithelial To Mesenchymal Transition Endoplasmic Reticulum Tubular Network Organization Regulation Of Branching Morphogenesis Of A Nerve	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Platelet Degranulation Protein Folding Organelle Organization Microtubule-based Process Blood Coagulation Platelet Activation Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization
Pathways		Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis p75 NTR receptor-mediated signalling	Transport of connexons to the plasma membrane Hedgehog 'off' state Platelet degranulation Formation of tubulin folding intermediates by CCT/TriC Regulation of PLK1 Activity at G2/M Transition Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Gap junction trafficking and regulation Response to elevated platelet cytosolic Ca2+ Recruitment of mitotic centrosome proteins and complexes Gap junction assembly Gap junction trafficking Factors involved in megakaryocyte development and platelet production Resolution of Sister Chromatid Cohesion Platelet activation, signaling and aggregation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes M Phase Intraflagellar transport Post-chaperonin tubulin folding pathway Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Protein folding Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Signaling by Hedgehog Chaperonin-mediated protein folding Centrosome maturation
Drugs			Vincristine Podofilox Epothilone D Epothilone B Cabazitaxel
Diseases
GWAS		Obesity (extreme) ( 19553259)
Protein-Protein Interactions		34 interactors: ARL6IP1 BAIAP2 BCL2 BCL2L1 CLN8 CNTNAP1 COL4A3BP CRMP1 FXR2 HLA-DPB1 LAMA4 LRCH4 LRPAP1 MBP NAPA NR4A1 PLEKHF2 POT1 PRR13 RAB33A RPS27 RTN3 RTN4IP1 RTN4R SNX1 SNX15 SPG21 SYT16 TERF1 TUBA4A UQCRC1 UQCRC2 WWP1 ZFYVE21	49 interactors: APC ARHGAP1 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 EGFR ENO2 EPB41 FYN GNAI2 GPHN GRM7 HDAC6 HSPH1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD PARK2 PFDN4 PLK1 RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 STARD13 SYK TAOK2 TBCB TBCE TCP1 TM4SF1 UCHL5 VAV1 VDAC1 YWHAG ZAP70
Entrez ID		57142	7277
HPRD ID		07259	01851
Ensembl ID		ENSG00000115310	ENSG00000127824
Uniprot IDs		Q9NQC3	A8MUB1 P68366
PDB IDs		2G31 2JV5
Enriched GO Terms of Interacting Partners?		Transport Establishment Of Localization In Cell Membrane Organization Cell Part Morphogenesis Intracellular Transport Negative Regulation Of Telomere Maintenance Via Telomerase Cellular Localization Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomerase Activity Mitochondrial Membrane Organization Regulation Of Telomere Maintenance Via Telomerase Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Anoikis Regulation Of Telomerase Activity Neuromuscular Process Controlling Posture Regulation Of Anoikis Regulation Of Telomere Maintenance Immune Response-regulating Signaling Pathway RNA-dependent DNA Replication Regulation Of Autophagy Mitochondrion Morphogenesis Cell Morphogenesis Negative Regulation Of DNA Biosynthetic Process Vesicle-mediated Transport Immune Response-activating Cell Surface Receptor Signaling Pathway System Development Neuron Differentiation Nervous System Development Axonogenesis Release Of Cytochrome C From Mitochondria Regulation Of Cellular Component Organization Cell Projection Morphogenesis Telomere Maintenance Via Telomere Lengthening Antigen Receptor-mediated Signaling Pathway Generation Of Neurons Anatomical Structure Development Aging Axon Development Developmental Process Negative Regulation Of Autophagy Regulation Of Mitochondrial Membrane Potential Response To Alkaloid Regulation Of Mitochondrial Membrane Permeability Cell Morphogenesis Involved In Neuron Differentiation Intracellular Protein Transport Regulation Of Organelle Organization Regulation Of Membrane Permeability Neurogenesis Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway	Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Apoptotic Process Response To Stress Programmed Cell Death Cell Death Death Positive Regulation Of Apoptotic Process Regulation Of Signaling Apoptotic Process Cell Migration Cell Communication Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Response To Stimulus Regulation Of Signal Transduction Cell Motility Regulation Of Intracellular Signal Transduction Response To Growth Factor Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Stimulus Intracellular Signal Transduction Regulation Of Catalytic Activity Locomotion Movement Of Cell Or Subcellular Component Response To Organic Substance Signaling Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization 'de Novo' Posttranslational Protein Folding Cellular Response To Growth Factor Stimulus 'de Novo' Protein Folding Neurotrophin TRK Receptor Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Leukocyte Migration Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Localization Regulation Of Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Regulation Of Microtubule-based Process Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		advance caspase caspases cdd corrected crosstalk disrupted doi emerges extrinsic flice flip flipl impinging initiator juxtaposition localizes mams mechanistically mefs mitochondria morphology platforms publication restrict reticulon shaping spatially tethering	34x10 abl1 applying await biology fyn gwas hypothesised illustrates inpp5d interactome interactomes interactor interactors kif1b loci pairwise phenotypes pik3r1 plcg1 prioritisation prioritization prkcd shared trait ubc unpredictable unravel
Tagcloud (Difference) ?		advance caspase caspases cdd corrected crosstalk disrupted doi emerges extrinsic flice flip flipl impinging initiator juxtaposition localizes mams mechanistically mefs mitochondria morphology platforms publication restrict reticulon shaping spatially tethering	34x10 abl1 applying await biology fyn gwas hypothesised illustrates inpp5d interactome interactomes interactor interactors kif1b loci pairwise phenotypes pik3r1 plcg1 prioritisation prioritization prkcd shared trait ubc unpredictable unravel
Tagcloud (Intersection) ?