RTN4 and HLA-DPB1

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		RTN4	HLA-DPB1
Name		reticulon 4	major histocompatibility complex, class II, DP beta 1
Structure
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Postsynaptic Density Membrane Cell Junction Cell Projection Neuron Projection Neuronal Cell Body Synapse Anchoring Junction Endoplasmic Reticulum Tubular Network Postsynapse Endoplasmic Reticulum Tubular Network Membrane Glutamatergic Synapse	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Cell Surface Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Cadherin Binding Metal Ion Binding	Protein Binding MHC Class II Protein Complex Binding Peptide Antigen Binding
	Biological Process	Blastocyst Formation Leukocyte Migration Involved In Inflammatory Response Apoptotic Process Endoplasmic Reticulum Organization Nervous System Development Axonal Fasciculation Brain Development Positive Regulation Of Epithelial Cell Migration Cerebral Cortex Radial Glia-guided Migration Central Nervous System Vasculogenesis Neuron Differentiation Negative Regulation Of Cell Growth Regulation Of Cell Migration Negative Regulation Of Axon Extension Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Rac Protein Signal Transduction Cell Migration Involved In Vasculogenesis Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Modulation Of Chemical Synaptic Transmission Protein Stabilization Nuclear Pore Complex Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Nervous System Development Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Cytokine Production Protein Localization To Lysosome Cellular Response To Hypoxia Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Intracellular Sphingolipid Homeostasis Cell Adhesion Involved In Sprouting Angiogenesis Regulation Of Postsynapse Assembly Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Neutrophil Migration Positive Regulation Of Macrophage Migration Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of ERBB3 Signaling Pathway Positive Regulation Of Artery Morphogenesis Endoplasmic Reticulum Tubular Network Membrane Organization Regulation Of Branching Morphogenesis Of A Nerve Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Vasculogenesis	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Type II Interferon Production Positive Regulation Of T Cell Proliferation Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation
Pathways		Axonal growth inhibition (RHOA activation)	Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling
Diseases		None	Dilated cardiomyopathy (DCM)
GWAS		Adult body size ( 32376654 ) Fasting glucose ( 34074324 ) Lymphocyte count ( 32888494 ) Obesity (extreme) ( 19553259 ) Platelet count ( 32888494 ) Systolic blood pressure ( 30224653 32902719 )	Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289 ) Alanine aminotransferase levels ( 34315874 ) Anti-rubella virus IgG levels ( 30053915 ) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757 ) Aspartate aminotransferase levels ( 34315874 ) Aspirin exacerbated respiratory disease in asthmatics ( 23180272 ) Asthma ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Chronic hepatitis B infection ( 24940741 25802187 ) Dermatomyositis ( 27153935 ) EGFR mutation-positive lung adenocarcinoma ( 27501781 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 ) Extranodal natural killer T-cell lymphoma (nasal type) ( 27470079 ) Gait speed in old age ( 28077804 ) Hepatitis B ( 33736632 21750111 19349983 ) Hepatitis B (viral clearance) ( 22737229 ) Hepatitis B vaccine response ( 21764829 ) Hip circumference adjusted for BMI ( 34021172 ) IgA nephropathy ( 25305756 ) Monocyte count ( 32888494 27863252 ) Myositis ( 26291516 ) Nephropathy ( 21399633 ) Neutrophil count ( 32888494 ) Nodular sclerosis Hodgkin lymphoma ( 29196614 ) Persistent hepatitis B virus infection ( 33736632 27244555 ) Plantar warts ( 28928442 ) Primary biliary cholangitis ( 28425483 ) Pulmonary arterial hypertension ( 30527956 ) Response to hepatitis B vaccine ( 29534301 31243853 ) Rosacea symptom severity ( 29771307 ) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848 ) Severe aplastic anemia ( 32004448 ) Sjögren's syndrome ( 28076899 24097066 ) Systemic sclerosis ( 21779181 ) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781 ) Wegener's granulomatosis ( 23740775 ) White blood cell count ( 32888494 ) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621 )
Novel Interactors		7 novel interactors: CGREF1 CHMP6 IPP NRXN1 NSD1 PPP1R21 STON1	1 novel interactors: HLA-DQA1
Interacting Genes		49 interacting genes: BAIAP2 BCL2 BCL2L1 BDKRB1 CCR4 CERT1 CHRM4 CLN8 CNTNAP1 CRMP1 CYSLTR2 DRD2 ERBB2 ERBB3 ERBB4 F2RL1 FXR2 GLP1R GPR35 HLA-DPB1 HTR2C LAMA4 LINC01554 LMNA LRCH4 LRPAP1 MBP NAPA NR4A1 OGT PLEKHF2 POT1 PRR13 RAB33A RNF10 RPS27 RTN3 RTN4IP1 RTN4R SNX1 SNX15 SPG21 SYT16 TERF1 TUBA4A UQCRC1 UQCRC2 WWP1 ZFYVE21	8 interacting genes: CD74 COPB1 HLA-DPA1 LZTS2 MEOX2 ROBO2 RTN4 TRIP6
Entrez ID		57142	3115
HPRD ID		07259	00832
Ensembl ID		ENSG00000115310	ENSG00000223865
Uniprot IDs		Q9NQC3	H0Y7G7 I4EC15 P04440
PDB IDs		2G31 2JV5	3LQZ 4P4K 4P4R 4P57 4P5K 4P5M 7T2A 7T2B 7T2C 7T2D
GO Terms Enriched among Interactors		Neuregulin Receptor Activity Membrane Organization Signal Transduction G Protein-coupled Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Presynapse ERBB3:ERBB2 Complex Glutamatergic Synapse Cell Projection Morphogenesis Dendritic Cell Apoptotic Process Membrane Neuromuscular Process Neuron Differentiation Response To Epidermal Growth Factor Protein Localization To Synapse Regulation Of Synapse Organization ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Rho Protein Signal Transduction ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway BH3 Domain Binding Cell Surface Receptor Signaling Pathway Cell Junction Organization Myelin Sheath Axonogenesis ERBB Signaling Pathway Endosome Neuromuscular Junction Non-canonical Inflammasome Complex Assembly Shelterin Complex Neuronal Signal Transduction Protein Localization To Cell Junction Mitochondrion Organization Cell Junction Assembly Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Projection Morphogenesis Signaling Receptor Activity Myelination Axon Ensheathment Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Establishment Of Localization In Cell Regulation Of ERK1 And ERK2 Cascade GABA-ergic Synapse Positive Regulation Of ERK1 And ERK2 Cascade Ceramide Binding ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway	MHC Class II Protein Complex MHC Class II Protein Complex Binding Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Transport Vesicle Membrane ER To Golgi Transport Vesicle Membrane Antigen Processing And Presentation Of Peptide Antigen Clathrin-coated Endocytic Vesicle Membrane Endocytic Vesicle Membrane MHC Class II Receptor Activity Antigen Processing And Presentation Trans-Golgi Network Membrane Peptide Antigen Assembly With MHC Class II Protein Complex Positive Regulation Of Macrophage Cytokine Production Endoplasmic Reticulum Membrane Regulation Of Locomotion Positive Regulation Of Neutrophil Migration Plasma Membrane Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Peptide Antigen Binding Regulation Of Macrophage Cytokine Production Golgi Membrane Regulation Of Neutrophil Migration Positive Regulation Of Immune Response Neuron Recognition Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion MHC Class II Protein Binding, Via Antigen Binding Groove NOS2-CD74 Complex Macrophage Migration Inhibitory Factor Signaling Pathway Adaptive Immune Response Cellular Component Assembly Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Primary Ureteric Bud Growth Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Negative Regulation Of Locomotion Positive Regulation Of Multicellular Organismal Process Lysosomal Membrane Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Immune Response