RTN4 and HLA-DPB1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		RTN4	HLA-DPB1
Gene Name		reticulon 4	major histocompatibility complex, class II, DP beta 1
Image
Gene Ontology Annotations	Cellular Component	Intracellular Nuclear Envelope Endoplasmic Reticulum Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Cell Projection Neuronal Cell Body Extracellular Vesicular Exosome	Golgi Membrane Lysosomal Membrane Plasma Membrane Cell Surface Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Poly(A) RNA Binding	Peptide Antigen Binding
	Biological Process	Angiogenesis Apoptotic Process Axonal Fasciculation Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of Cell Growth Regulation Of Cell Migration Negative Regulation Of Axon Extension Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Cardiac Epithelial To Mesenchymal Transition Endoplasmic Reticulum Tubular Network Organization Regulation Of Branching Morphogenesis Of A Nerve	Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation Positive Regulation Of Interferon-gamma Production Positive Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Interferon-gamma-mediated Signaling Pathway
Pathways		Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis p75 NTR receptor-mediated signalling	Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS		Obesity (extreme) ( 19553259)	Aspirin exacerbated respiratory disease in asthmatics ( 23180272) Hepatitis B ( 21750111 19349983) Hepatitis B (viral clearance) ( 22737229) Hepatitis B vaccine response ( 21764829) Nephropathy ( 21399633) Systemic sclerosis ( 21779181) Wegener's granulomatosis ( 23740775)
Protein-Protein Interactions		34 interactors: ARL6IP1 BAIAP2 BCL2 BCL2L1 CLN8 CNTNAP1 COL4A3BP CRMP1 FXR2 HLA-DPB1 LAMA4 LRCH4 LRPAP1 MBP NAPA NR4A1 PLEKHF2 POT1 PRR13 RAB33A RPS27 RTN3 RTN4IP1 RTN4R SNX1 SNX15 SPG21 SYT16 TERF1 TUBA4A UQCRC1 UQCRC2 WWP1 ZFYVE21	7 interactors: CD74 COPB1 HLA-DPA1 LZTS2 ROBO2 RTN4 TRIP6
Entrez ID		57142	3115
HPRD ID		07259	00832
Ensembl ID		ENSG00000115310
Uniprot IDs		Q9NQC3	I4EC15 P04440
PDB IDs		2G31 2JV5	3LQZ
Enriched GO Terms of Interacting Partners?		Transport Establishment Of Localization In Cell Membrane Organization Cell Part Morphogenesis Intracellular Transport Negative Regulation Of Telomere Maintenance Via Telomerase Cellular Localization Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomerase Activity Mitochondrial Membrane Organization Regulation Of Telomere Maintenance Via Telomerase Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Anoikis Regulation Of Telomerase Activity Neuromuscular Process Controlling Posture Regulation Of Anoikis Regulation Of Telomere Maintenance Immune Response-regulating Signaling Pathway RNA-dependent DNA Replication Regulation Of Autophagy Mitochondrion Morphogenesis Cell Morphogenesis Negative Regulation Of DNA Biosynthetic Process Vesicle-mediated Transport Immune Response-activating Cell Surface Receptor Signaling Pathway System Development Neuron Differentiation Nervous System Development Axonogenesis Release Of Cytochrome C From Mitochondria Regulation Of Cellular Component Organization Cell Projection Morphogenesis Telomere Maintenance Via Telomere Lengthening Antigen Receptor-mediated Signaling Pathway Generation Of Neurons Anatomical Structure Development Aging Axon Development Developmental Process Negative Regulation Of Autophagy Regulation Of Mitochondrial Membrane Potential Response To Alkaloid Regulation Of Mitochondrial Membrane Permeability Cell Morphogenesis Involved In Neuron Differentiation Intracellular Protein Transport Regulation Of Organelle Organization Regulation Of Membrane Permeability Neurogenesis Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway	Regulation Of Locomotion Neuron Recognition Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Macrophage Migration Inhibitory Factor Signaling Pathway Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Migration Cell Recognition Negative Regulation Of Negative Chemotaxis Regulation Of Cell Motility Signal Transduction Regulation Of Chemotaxis Regulation Of Cellular Component Movement Apoptotic Process Involved In Luteolysis Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Axonogenesis Signaling Cellular Response To Organic Substance Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Negative Chemotaxis Negative Regulation Of Mature B Cell Apoptotic Process Cell Communication Regulation Of Behavior Regulation Of Protein Localization To Nucleus Axon Midline Choice Point Recognition Luteolysis Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Axon Choice Point Recognition Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Cell-cell Adhesion Endoplasmic Reticulum Tubular Network Organization Cellular Response To Stimulus Olfactory Bulb Interneuron Development Antigen Processing And Presentation Telencephalon Development Spindle Midzone Assembly Positive Thymic T Cell Selection Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Negative Regulation Of B Cell Apoptotic Process Kidney Development Response To Organic Substance COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Tagcloud ?		advance caspase caspases cdd corrected crosstalk disrupted doi emerges extrinsic flice flip flipl impinging initiator juxtaposition localizes mams mechanistically mefs mitochondria morphology platforms publication restrict reticulon shaping spatially tethering
Tagcloud (Difference) ?		advance caspase caspases cdd corrected crosstalk disrupted doi emerges extrinsic flice flip flipl impinging initiator juxtaposition localizes mams mechanistically mefs mitochondria morphology platforms publication restrict reticulon shaping spatially tethering
Tagcloud (Intersection) ?