FAM20C and SUV39H2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		FAM20C	SUV39H2
Description		FAM20C golgi associated secretory pathway kinase	SUV39H2 histone lysine methyltransferase
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Membrane Extracellular Exosome	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome
	Molecular Function	Nucleotide Binding Protease Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Manganese Ion Binding Metal Ion Binding Protein Serine Kinase Activity	Transcription Cis-regulatory Region Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9 Trimethyltransferase Activity S-adenosyl-L-methionine Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Skeletal System Development Protein Phosphorylation Positive Regulation Of Bone Mineralization Biomineral Tissue Development Osteoclast Maturation Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Positive Regulation Of Osteoblast Differentiation Regulation Of Phosphorus Metabolic Process Enamel Mineralization Odontoblast Differentiation Dentinogenesis	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Circadian Rhythm Cell Differentiation Methylation Epigenetic Programming In The Zygotic Pronuclei Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Hypoxia
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	PKMTs methylate histone lysines
Drugs
Diseases		Raine syndrome; Lethal osteosclerotic bone dysplasia
GWAS		Allergic rhinitis ( 25085501) Alzheimer's disease in APOE e4- carriers ( 25778476)	Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		8 interacting genes: FAM118B P4HB PFDN1 SMN1 SUV39H2 TAF1D TK1 TSC22D1	43 interacting genes: AKAP9 APPL2 AR BLZF1 C8orf74 CBX7 CDCA4 CEP70 CFAP100 CGGBP1 EWSR1 FAM20C GOLGA6L9 GSTCD H3C1 ID2 KCTD17 KLF3 KLHDC4 LCA5L LNX1 LRIF1 MAGEA11 MCM3AP MRFAP1 MTF2 MYL12A NME4 ODAD3 PHF19 PNMA1 POLR3F RAB3IP RASSF1 SHC1 SMAD5 SNF8 UBE2V2 VHL WIZ ZNF212 ZNF557 ZNF57
Entrez ID		56975	79723
HPRD ID		13298	07580
Ensembl ID		ENSG00000177706	ENSG00000152455
Uniprot IDs		Q8IXL6	Q9H5I1
PDB IDs		5YH3	2R3A 6P0R
Enriched GO Terms of Interacting Partners?		Cellular Response To Decreased Oxygen Levels Procollagen-proline 4-dioxygenase Activity Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Cellular Response To Oxygen Levels Cellular Response To Hypoxia Peptidyl-proline Hydroxylation Procollagen-proline 4-dioxygenase Complex Cajal Body Identical Protein Binding DNA Synthesis Involved In Mitotic DNA Replication Thymidine Biosynthetic Process Thymidine Kinase Activity Negative Regulation Of Hematopoietic Stem Cell Proliferation RNA Polymerase Transcription Factor SL1 Complex Histone H3K9 Trimethyltransferase Activity Interleukin-23-mediated Signaling Pathway Thiol Oxidase Activity Prefoldin Complex Thymidine Metabolic Process Protein Folding Insulin Processing Interleukin-12-mediated Signaling Pathway Deoxyribonucleoside Monophosphate Biosynthetic Process	Nucleoplasm Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone H3K36me3 Reader Activity Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
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