FAM20C and PFDN1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		FAM20C	PFDN1
Description		FAM20C golgi associated secretory pathway kinase	prefoldin subunit 1
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Membrane Extracellular Exosome	Cytoplasm Prefoldin Complex Protein-containing Complex
	Molecular Function	Nucleotide Binding Protease Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Manganese Ion Binding Metal Ion Binding Protein Serine Kinase Activity	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Skeletal System Development Protein Phosphorylation Positive Regulation Of Bone Mineralization Biomineral Tissue Development Osteoclast Maturation Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Positive Regulation Of Osteoblast Differentiation Regulation Of Phosphorus Metabolic Process Enamel Mineralization Odontoblast Differentiation Dentinogenesis	Protein Folding Negative Regulation Of Amyloid Fibril Formation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases		Raine syndrome; Lethal osteosclerotic bone dysplasia
GWAS		Allergic rhinitis ( 25085501) Alzheimer's disease in APOE e4- carriers ( 25778476)	Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)
Interacting Genes		8 interacting genes: FAM118B P4HB PFDN1 SMN1 SUV39H2 TAF1D TK1 TSC22D1	55 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEBPA CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235
Entrez ID		56975	5201
HPRD ID		13298	05357
Ensembl ID		ENSG00000177706	ENSG00000113068
Uniprot IDs		Q8IXL6	O60925
PDB IDs		5YH3	6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
Enriched GO Terms of Interacting Partners?		Cellular Response To Decreased Oxygen Levels Procollagen-proline 4-dioxygenase Activity Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Cellular Response To Oxygen Levels Cellular Response To Hypoxia Peptidyl-proline Hydroxylation Procollagen-proline 4-dioxygenase Complex Cajal Body Identical Protein Binding DNA Synthesis Involved In Mitotic DNA Replication Thymidine Biosynthetic Process Thymidine Kinase Activity Negative Regulation Of Hematopoietic Stem Cell Proliferation RNA Polymerase Transcription Factor SL1 Complex Histone H3K9 Trimethyltransferase Activity Interleukin-23-mediated Signaling Pathway Thiol Oxidase Activity Prefoldin Complex Thymidine Metabolic Process Protein Folding Insulin Processing Interleukin-12-mediated Signaling Pathway Deoxyribonucleoside Monophosphate Biosynthetic Process	Positive Regulation Of Microtubule Nucleation Structural Constituent Of Cytoskeleton Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Microtubule Nucleation Nuclear Matrix Positive Regulation Of DNA Recombination NuA4 Histone Acetyltransferase Complex Regulation Of Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Double-strand Break Repair Intracellular Protein Localization Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Glutamate Receptor Binding Regulation Of Cellular Component Organization
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