FAM20C

Description		FAM20C golgi associated secretory pathway kinase
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protease Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Manganese Ion Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Skeletal System Development Protein Phosphorylation Positive Regulation Of Bone Mineralization Biomineral Tissue Development Osteoclast Maturation Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Positive Regulation Of Osteoblast Differentiation Regulation Of Phosphorus Metabolic Process Enamel Mineralization Odontoblast Differentiation Dentinogenesis
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases		Raine syndrome; Lethal osteosclerotic bone dysplasia
GWAS		Allergic rhinitis ( 25085501) Alzheimer's disease in APOE e4- carriers ( 25778476)
Interacting Genes		8 interacting genes: FAM118B P4HB PFDN1 SMN1 SUV39H2 TAF1D TK1 TSC22D1
Entrez ID		56975
HPRD ID		13298
Ensembl ID		ENSG00000177706
Uniprot IDs		Q8IXL6
PDB IDs		5YH3
Enriched GO Terms of Interacting Partners?		Cellular Response To Decreased Oxygen Levels Procollagen-proline 4-dioxygenase Activity Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Cellular Response To Oxygen Levels Cellular Response To Hypoxia Peptidyl-proline Hydroxylation Procollagen-proline 4-dioxygenase Complex Cajal Body Identical Protein Binding DNA Synthesis Involved In Mitotic DNA Replication Thymidine Biosynthetic Process Thymidine Kinase Activity Negative Regulation Of Hematopoietic Stem Cell Proliferation RNA Polymerase Transcription Factor SL1 Complex Histone H3K9 Trimethyltransferase Activity Interleukin-23-mediated Signaling Pathway Thiol Oxidase Activity Prefoldin Complex Thymidine Metabolic Process Protein Folding Insulin Processing Interleukin-12-mediated Signaling Pathway Deoxyribonucleoside Monophosphate Biosynthetic Process
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