PSMB8 and PFDN5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PSMB8	PFDN5
Description		proteasome 20S subunit beta 8	prefoldin subunit 5
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Extracellular Exosome Spermatoproteasome Complex	Nucleus Cytoplasm Cytosol Prefoldin Complex Protein-containing Complex Intermediate Filament Cytoskeleton
	Molecular Function	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	Amyloid-beta Binding Transcription Corepressor Activity Protein Binding Unfolded Protein Binding
	Biological Process	Immune System Process Proteolysis Antigen Processing And Presentation Cell Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Fat Cell Differentiation Proteolysis Involved In Protein Catabolic Process	Regulation Of DNA-templated Transcription Protein Folding Negative Regulation Of DNA-templated Transcription Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Amyloid Fibril Formation RNA Polymerase I Assembly RNA Polymerase II Core Complex Assembly RNA Polymerase III Assembly
Pathways		ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Interferon alpha/beta signaling Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation	Prefoldin mediated transfer of substrate to CCT/TriC
Drugs		Carfilzomib
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) IgA nephropathy ( 25305756 32912934) Nephropathy ( 21399633)
Interacting Genes		22 interacting genes: ABCB1 DUSP23 GNPNAT1 INCA1 LSM1 MEOX2 NFKBID PFDN5 POLR2G POMP PSMB10 REL SNX5 TAP1 TAP2 TENT5B TRAF3 TRIP13 UBAP2 WWOX YJEFN3 ZMYND12	113 interacting genes: ABI2 ANKRD55 ATOSB BCAS2 BCL6 BHLHE40 BRMS1 C10orf55 C10orf62 C22orf39 CALCOCO2 CCDC198 CEBPA CIMIP1 CSPP1 DMRT3 DOK4 DOK5 EEIG1 ELK3 ESPNL FAAP20 FAM110A FAM221A FAM222B FAM90A1 GLRX3 GLYCTK GPANK1 GSTO2 GUCD1 HAPLN2 HHEX HOXB9 HOXC8 IKBKG IKZF3 IL16 INCA1 IRX2 IRX6 ITSN1 KCTD9 KDM1A KLHL38 KLHL42 LARP4 LNX1 MAP2K5 METTL21A MISP MRPL45 MYC MYOT MYOZ1 NEUROG2 NOXA1 NTAQ1 PATZ1 PAX9 PFDN6 PHF1 PHF24 PILRA PITX1 PITX2 POGZ PRKAB2 PRPF18 PRR35 PSMB4 PSMB8 PSME3 RIBC1 RIPPLY1 RSRC2 RUSC1 SAXO1 SAXO4 SCNM1 SDCBP SHISA6 SLAIN1 SMAP1 SMG9 SNAI1 SNRNP25 SNRPB SOHLH1 SPAG8 SPG21 SPMIP2 SPMIP4 SYCE1L SYT17 TAF6L TBX3 TCF19 TFG TLE5 TP73 TRAPPC6A TRIM28 TUBA1B TUBA3C VAX2 VEZF1 VGLL1 WDR25 WHR1 YPEL5 ZC2HC1C ZNF148
Entrez ID		5696	5204
HPRD ID		01515	05359
Ensembl ID		ENSG00000204264	ENSG00000123349
Uniprot IDs		P28062	Q99471
PDB IDs		5L5A 5L5B 5L5D 5L5E 5L5F 5L5H 5L5I 5L5J 5L5O 5L5P 5L5Q 5L5R 5L5S 5L5T 5L5U 5L5V 5LTT 5M2B 6AVO 6E5B 7AWE 7B12	6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
Enriched GO Terms of Interacting Partners?		Peptide Transmembrane Transporter Activity ABC-type Peptide Antigen Transporter Activity TAP Complex ABC-type Peptide Transporter Activity TAP1 Binding Cytosol To Endoplasmic Reticulum Transport ABC-type Transporter Activity MHC Class Ib Protein Binding MHC Protein Binding MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex P-body Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I RNA Polymerase III Assembly RNA Polymerase I Assembly Cellular Response To Nonylphenol Response To Quercetin Cellular Response To Borneol Response To Codeine Amide Transport Daunorubicin Transport Positive Regulation Of Establishment Of Sertoli Cell Barrier Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Antigen Processing And Presentation Of Endogenous Antigen Tapasin Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Macropinocytic Cup Glucosamine 6-phosphate N-acetyltransferase Activity ATP Hydrolysis Activity	Protein Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Pattern Specification Process MRF Binding Regionalization Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process E-box Binding Axonemal A Tubule Inner Sheath
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