PSMB8 and TENT5B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PSMB8	TENT5B
Description		proteasome 20S subunit beta 8	terminal nucleotidyltransferase 5B
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Extracellular Exosome Spermatoproteasome Complex	Nucleus Cytoplasm
	Molecular Function	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	Protein Binding Transferase Activity Nucleotidyltransferase Activity Poly(A) RNA Polymerase Activity
	Biological Process	Immune System Process Proteolysis Antigen Processing And Presentation Cell Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Fat Cell Differentiation Proteolysis Involved In Protein Catabolic Process	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Translation Negative Regulation Of Cell Cycle MRNA Stabilization
Pathways		ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Interferon alpha/beta signaling Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation
Drugs		Carfilzomib
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) IgA nephropathy ( 25305756 32912934) Nephropathy ( 21399633)
Interacting Genes		22 interacting genes: ABCB1 DUSP23 GNPNAT1 INCA1 LSM1 MEOX2 NFKBID PFDN5 POLR2G POMP PSMB10 REL SNX5 TAP1 TAP2 TENT5B TRAF3 TRIP13 UBAP2 WWOX YJEFN3 ZMYND12	61 interacting genes: ACY1 AKAP8L AKAP9 ATXN1 BHLHE40 C10orf55 C3orf36 CERCAM CIMIP2B CYSRT1 DAZAP2 ENKD1 FAM168B FOS FOSB FOXI1 HIVEP1 HMGXB4 HNRNPF KLHL38 KRT34 KRTAP19-6 KRTAP6-1 KRTAP6-2 MGAT5B MKRN3 NAF1 NICN1 NR1D2 OTX2 PLK4 POU2AF1 POU6F2 PROP1 PSMB8 PSMF1 RBPMS2 RFX6 RHOXF2 RIMBP3C RUSC1 SLC15A2 SLC27A4 SMAP2 SOHLH1 SOX5 SPAG8 TBX6 TENT5A TLE5 TNS2 TRIP13 UBAP2 UBQLN2 USP54 YPEL3 ZBTB2 ZC3H10 ZNF503 ZNF620 ZNF688
Entrez ID		5696	115572
HPRD ID		01515	16882
Ensembl ID		ENSG00000204264	ENSG00000158246
Uniprot IDs		P28062	Q96A09
PDB IDs		5L5A 5L5B 5L5D 5L5E 5L5F 5L5H 5L5I 5L5J 5L5O 5L5P 5L5Q 5L5R 5L5S 5L5T 5L5U 5L5V 5LTT 5M2B 6AVO 6E5B 7AWE 7B12
Enriched GO Terms of Interacting Partners?		Peptide Transmembrane Transporter Activity ABC-type Peptide Antigen Transporter Activity TAP Complex ABC-type Peptide Transporter Activity TAP1 Binding Cytosol To Endoplasmic Reticulum Transport ABC-type Transporter Activity MHC Class Ib Protein Binding MHC Protein Binding MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex P-body Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I RNA Polymerase III Assembly RNA Polymerase I Assembly Cellular Response To Nonylphenol Response To Quercetin Cellular Response To Borneol Response To Codeine Amide Transport Daunorubicin Transport Positive Regulation Of Establishment Of Sertoli Cell Barrier Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Antigen Processing And Presentation Of Endogenous Antigen Tapasin Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Macropinocytic Cup Glucosamine 6-phosphate N-acetyltransferase Activity ATP Hydrolysis Activity	Identical Protein Binding DNA-binding Transcription Factor Activity DNA Binding Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Nucleus Chromatin RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process
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