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PSMB8 and TAP1
Number of citations of the paper that reports this interaction (PMID
15488952
)
3
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
PSMB8
TAP1
Gene Name
proteasome (prosome, macropain) subunit, beta type, 8
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Proteasome Complex
Nucleoplasm
Cytosol
Proteasome Core Complex
Extracellular Vesicular Exosome
Spermatoproteasome Complex
Mitochondrion
Endoplasmic Reticulum Membrane
Membrane
Integral Component Of Membrane
Integral Component Of Endoplasmic Reticulum Membrane
TAP Complex
Molecular Function
Threonine-type Endopeptidase Activity
Protein Binding
Protein Binding
ATP Binding
Peptide Transporter Activity
Peptide-transporting ATPase Activity
MHC Class Ib Protein Binding
MHC Class I Protein Binding
Peptide Antigen Binding
ATPase Activity, Coupled To Transmembrane Movement Of Substances
Protein Homodimerization Activity
ADP Binding
TAP1 Binding
TAP2 Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Gene Expression
Viral Process
Cytokine-mediated Signaling Pathway
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Small Molecule Metabolic Process
Fat Cell Differentiation
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Type I Interferon Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Defense Response
Metabolic Process
Peptide Transport
Intracellular Transport Of Viral Protein In Host Cell
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Cytosol To ER Transport
Transmembrane Transport
Pathways
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
Hh ligand biogenesis disease
T41 mutants of beta-catenin aren't phosphorylated
Downstream signaling events of B Cell Receptor (BCR)
Degradation of beta-catenin by the destruction complex
Stabilization of p53
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Regulation of mRNA stability by proteins that bind AU-rich elements
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
DNA Replication Pre-Initiation
S45 mutants of beta-catenin aren't phosphorylated
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
deletions in the AMER1 gene destabilize the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
AMER1 mutants destabilize the destruction complex
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PCP/CE pathway
Adaptive Immune System
CDK-mediated phosphorylation and removal of Cdc6
Hedgehog ligand biogenesis
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
HIV Infection
Ubiquitin-dependent degradation of Cyclin D
APC truncation mutants have impaired AXIN binding
Assembly of the pre-replicative complex
Autodegradation of Cdh1 by Cdh1:APC/C
p53-Dependent G1 DNA Damage Response
S37 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
p53-Independent DNA Damage Response
p53-Independent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Vpu mediated degradation of CD4
Synthesis of DNA
Interferon Signaling
M/G1 Transition
Ubiquitin-dependent degradation of Cyclin D1
TCF dependent signaling in response to WNT
SCF-beta-TrCP mediated degradation of Emi1
degradation of AXIN
Signaling by Hedgehog
Regulation of mitotic cell cycle
Degradation of GLI1 by the proteasome
degradation of DVL
Cell Cycle Checkpoints
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Regulation of Apoptosis
Degradation of GLI2 by the proteasome
Signaling by the B Cell Receptor (BCR)
Vif-mediated degradation of APOBEC3G
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
p53-Dependent G1/S DNA damage checkpoint
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
Cyclin E associated events during G1/S transition
APC/C:Cdc20 mediated degradation of Securin
AUF1 (hnRNP D0) destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
RNF mutants show enhanced WNT signaling and proliferation
G1/S Transition
truncations of AMER1 destabilize the destruction complex
Processing-defective Hh variants abrogate ligand secretion
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
Regulation of activated PAK-2p34 by proteasome mediated degradation
AXIN missense mutants destabilize the destruction complex
S Phase
APC/C-mediated degradation of cell cycle proteins
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic Metaphase and Anaphase
Regulation of ornithine decarboxylase (ODC)
Antigen processing: Ubiquitination & Proteasome degradation
Orc1 removal from chromatin
Mitotic Anaphase
M Phase
APC truncation mutants are not K63 polyubiquitinated
Metabolism of amino acids and derivatives
Hedgehog 'on' state
Programmed Cell Death
Interferon alpha/beta signaling
Class I MHC mediated antigen processing & presentation
Regulation of DNA replication
Cytokine Signaling in Immune system
Cell Cycle, Mitotic
beta-catenin independent WNT signaling
Orc1 removal from chromatin
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Antigen processing-Cross presentation
CDT1 association with the CDC6:ORC:origin complex
ER-Phagosome pathway
Class I MHC mediated antigen processing & presentation
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
ER-Phagosome pathway
Adaptive Immune System
Drugs
Diseases
GWAS
Nephropathy (
21399633
)
Nephropathy (
21399633
)
Protein-Protein Interactions
9 interactors:
ABCB1
LSM1
POMP
PSMA6
PSMB10
PSMB3
PSMB9
TAP1
TAP2
12 interactors:
ESR1
HLA-F
HLA-G
KRTAP4-12
MDFI
MUL1
PDIA3
PSMB5
PSMB8
TAP2
TAPBP
TDP2
Entrez ID
5696
6890
HPRD ID
01515
01359
Ensembl ID
ENSG00000204264
ENSG00000168394
Uniprot IDs
P28062
F5H648
Q03518
PDB IDs
1JJ7
Enriched GO Terms of Interacting Partners
?
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Peptide Antigen
Antigen Processing And Presentation
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Signal Transduction Involved In DNA Damage Checkpoint
Signal Transduction Involved In Cell Cycle Checkpoint
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Mitotic G1 DNA Damage Checkpoint
Positive Regulation Of Ubiquitin-protein Transferase Activity
Mitotic G1/S Transition Checkpoint
G1 DNA Damage Checkpoint
Positive Regulation Of Cell Cycle Arrest
Viral Process
Positive Regulation Of Ligase Activity
DNA Damage Response, Signal Transduction By P53 Class Mediator
Mitotic Cell Cycle Phase Transition
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Cell Cycle Phase Transition
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Signal Transduction In Response To DNA Damage
Mitotic DNA Damage Checkpoint
Regulation Of Cell Cycle Arrest
Mitotic DNA Integrity Checkpoint
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Protein Ubiquitination
Signal Transduction By P53 Class Mediator
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Cytosol To ER Transport
Positive Regulation Of Protein Ubiquitination
Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Cellular Protein Catabolic Process
DNA Damage Checkpoint
Positive Regulation Of Wnt Signaling Pathway
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Checkpoint
Protein Polyubiquitination
Negative Regulation Of Wnt Signaling Pathway
Regulation Of Protein Ubiquitination
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Peptide Antigen
Antigen Processing And Presentation
Positive Regulation Of Signal Transduction
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I
Immune System Process
Antigen Processing And Presentation Of Endogenous Antigen
Type I Interferon Signaling Pathway
Cellular Response To Type I Interferon
Response To Type I Interferon
Response To Stress
Cellular Response To Stress
Signal Transduction
Negative Regulation Of Signal Transduction
Signaling
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Transferase Activity
Cell Communication
Negative Regulation Of Signaling
Activation Of JUN Kinase Activity
Response To Stimulus
Regulation Of Apoptotic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Proteolysis
Cellular Response To Stimulus
Regulation Of Wnt Signaling Pathway
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Signal Transduction Involved In DNA Damage Checkpoint
Signal Transduction Involved In Cell Cycle Checkpoint
Positive Regulation Of Catalytic Activity
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent
Regulation Of Cell Death
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of JUN Kinase Activity
Peptide Antigen Stabilization
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Mitotic G1 DNA Damage Checkpoint
Positive Regulation Of Ubiquitin-protein Transferase Activity
Mitotic G1/S Transition Checkpoint
G1 DNA Damage Checkpoint
Positive Regulation Of Cell Cycle Arrest
Positive Regulation Of Protein Modification Process
Positive Regulation Of Ligase Activity
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of JUN Kinase Activity
Tagcloud
?
activates
acts
blocks
contain
crossover
crossovers
demonstrating
dominan
ecs
element
gamma
gas
hela
homodimers
ifn
isre
jak1
jaks
janus
p48
permits
phosphatase
shp
ss
stat1
stat1alpha
stat2
transporter
tyk
Tagcloud (Difference)
?
activates
acts
blocks
contain
crossover
crossovers
demonstrating
dominan
ecs
element
gamma
gas
hela
homodimers
ifn
isre
jak1
jaks
janus
p48
permits
phosphatase
shp
ss
stat1
stat1alpha
stat2
transporter
tyk
Tagcloud (Intersection)
?