LHX9 and LDB2

Number of citations of the paper that reports this interaction (PMID 9880598)
16

Data Source:
HPRD (in vitro)

		LHX9	LDB2
Gene Name		LIM homeobox 9	LIM domain binding 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Transcription Factor Complex
	Molecular Function	Transcription Corepressor Activity Zinc Ion Binding Sequence-specific DNA Binding	Transcription Cofactor Activity Enzyme Binding LIM Domain Binding
	Biological Process	Motor Neuron Axon Guidance Cell Proliferation Male Gonad Development Female Gonad Development Gonad Morphogenesis Negative Regulation Of Transcription, DNA-templated	Hair Follicle Development Epithelial Structure Maintenance Somatic Stem Cell Maintenance Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS			QT interval ( 23534349) Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		5 interactors: CWF19L2 KHK LDB2 SMAD2 SMURF1	12 interactors: ISL1 LHX4 LHX9 LMO3 LMO4 RASIP1 RILP RLIM SSBP2 SSBP3 SSBP4 TSNAX
Entrez ID		56956	9079
HPRD ID		07299	16022
Ensembl ID		ENSG00000143355	ENSG00000169744
Uniprot IDs		Q9NQ69	B7Z2D3 E9PFI4 G5E9Y7 O43679
PDB IDs		2DMQ
Enriched GO Terms of Interacting Partners?		Somatic Stem Cell Maintenance Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of BMP Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Stem Cell Maintenance Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Fructose Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Zygotic Specification Of Dorsal/ventral Axis Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Stem Cell Development Positive Regulation Of Mesoderm Development Primary MiRNA Processing Ubiquitin-dependent SMAD Protein Catabolic Process Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Stem Cell Differentiation SMAD Protein Complex Assembly Paraxial Mesoderm Morphogenesis Nodal Signaling Pathway Tissue Development Fructose Metabolic Process Protein Localization To Cell Surface Epithelial Structure Maintenance Regulation Of Transcription From RNA Polymerase II Promoter Receptor Catabolic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Embryonic Foregut Morphogenesis Foregut Morphogenesis Regulation Of Activin Receptor Signaling Pathway Paraxial Mesoderm Development Response To Cholesterol Dorsal/ventral Axis Specification Ectoderm Development Cellular Response To Growth Factor Stimulus Pericardium Development Response To Growth Factor Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Signal Transduction Involved In Regulation Of Gene Expression Gene Silencing By MiRNA Cellular Response To DsRNA Positive Regulation Of BMP Signaling Pathway	Spinal Cord Motor Neuron Differentiation Ventral Spinal Cord Development Cell Differentiation In Spinal Cord Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Spinal Cord Development Regulation Of Gene Expression Anatomical Structure Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Regulation Of Metabolic Process Neural Tube Development Motor Neuron Axon Guidance Central Nervous System Neuron Differentiation Negative Regulation Of Cellular Metabolic Process Tissue Morphogenesis RNA Metabolic Process Tube Development Multicellular Organismal Development Cell Differentiation Nervous System Development Transcription, DNA-templated Gene Expression RNA Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Gonad Morphogenesis Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Midbrain-hindbrain Boundary Initiation Prechordal Plate Formation Random Inactivation Of X Chromosome Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Epithelial Tube Morphogenesis Tissue Development Cardiac Septum Development Axon Guidance Developmental Process Central Nervous System Development System Development Tube Morphogenesis Positive Regulation Of Granulocyte Colony-stimulating Factor Production Positive Regulation Of Macrophage Colony-stimulating Factor Production Medial Motor Column Neuron Differentiation Positive Regulation Of Anterior Head Development Neural Tube Closure Epithelium Development Negative Regulation Of Transcription, DNA-templated
Tagcloud ?		amph aqp5 azad bfh bisulfite cobra dcc demethylating deoxycytidine en2 fl gad2 gjd2 gpr61 gria4 homeobox hoxa11 hoxb7 hoxc12 hoxd10 hypermethylated lymphomagenesis minus pax6 pax7 reactivated rl sfmbt2 suz12	ablated abundant belong belongs brdu crypt endoderm endodermal gut homeobox intestine isl1 isl2 islet1 ldb1 lhx lhx1 lim lineages lmx1a lmx1b mesodermal obligatory patterning prominently quiescent terminally tracing
Tagcloud (Difference) ?		amph aqp5 azad bfh bisulfite cobra dcc demethylating deoxycytidine en2 fl gad2 gjd2 gpr61 gria4 hoxa11 hoxb7 hoxc12 hoxd10 hypermethylated lymphomagenesis minus pax6 pax7 reactivated rl sfmbt2 suz12	ablated abundant belong belongs brdu crypt endoderm endodermal gut intestine isl1 isl2 islet1 ldb1 lhx lhx1 lim lineages lmx1a lmx1b mesodermal obligatory patterning prominently quiescent terminally tracing
Tagcloud (Intersection) ?		homeobox