LDB2 and LHX9

Number of citations of the paper that reports this interaction (PubMedID 9880598)
39

Data Source:
HPRD (in vitro)

		LDB2	LHX9
Description		LIM domain binding 2	LIM homeobox 9
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Plasma Membrane Cell Leading Edge	Chromatin Nucleus
	Molecular Function	Transcription Coregulator Activity Protein Binding Enzyme Binding LIM Domain Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Hair Follicle Development Nervous System Development Epithelial Structure Maintenance Regulation Of Cell Migration Somatic Stem Cell Population Maintenance Regulation Of Kinase Activity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Male Gonad Development Female Gonad Development Neuron Differentiation Gonad Morphogenesis Negative Regulation Of DNA-templated Transcription Dorsal Spinal Cord Interneuron Anterior Axon Guidance
Pathways			Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) Glucocorticoid receptor gene expression in B-cell precursor acute lymphoblastic leukaemia ( 33002292) Liver fibrosis (total hepatic collagen content) ( 32953199) Number of sexual partners ( 30643258) QT interval ( 23534349) Rhegmatogenous retinal detachment ( 23585552) Systemic juvenile idiopathic arthritis ( 27927641) Waist circumference ( 28552196)	General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549)
Interacting Genes		31 interacting genes: C14orf119 CETN3 DGCR6L EGLN3 EPM2AIP1 EXOC3L1 GGACT GRIK1 HDAC7 ISL1 LHX3 LHX4 LHX8 LHX9 LMO1 LMO2 LMO3 LMO4 LNX1 NTAQ1 PSMB1 RASIP1 RILP RLIM SDCBP SMARCD1 SSBP2 SSBP3 SSBP4 TSNAX TTC19	8 interacting genes: CSNK2A1 CWF19L2 IGFN1 KHK LDB2 SMAD2 SMURF1 UBTFL1
Entrez ID		9079	56956
HPRD ID		16022	07299
Ensembl ID		ENSG00000169744	ENSG00000143355
Uniprot IDs		B7Z6D0 E9PFI4 G5E9Y7 O43679	H0YL54 Q9NQ69
PDB IDs			2DMQ
Enriched GO Terms of Interacting Partners?		Spinal Cord Motor Neuron Cell Fate Specification Cell Differentiation In Spinal Cord Regulation Of Transcription By RNA Polymerase II Medial Motor Column Neuron Differentiation Neuron Fate Specification DNA-binding Transcription Factor Binding Motor Neuron Axon Guidance Nucleus Neuron Projection Guidance Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Neuron Differentiation Axon Guidance Positive Regulation Of Transcription By RNA Polymerase II Single-stranded DNA Binding Transcription Regulator Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Transcription Coactivator Activity Spinal Cord Association Neuron Differentiation Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cell Fate Specification Positive Regulation Of Nucleobase-containing Compound Metabolic Process Metal Ion Binding Spinal Cord Motor Neuron Differentiation Regulation Of Metabolic Process Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Macromolecule Biosynthetic Process BHLH Transcription Factor Binding Regulation Of Gene Expression Pituitary Gland Development Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Neuron Projection Development Interleukin-5 Receptor Complex Prechordal Plate Formation Midbrain-hindbrain Boundary Initiation Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Dorsal Spinal Cord Interneuron Anterior Axon Guidance Gamma-glutamylaminecyclotransferase Activity Positive Regulation Of Macromolecule Metabolic Process Central Nervous System Neuron Differentiation Transcription Coregulator Binding	Protein Targeting To Vacuole Involved In Autophagy I-SMAD Binding Transforming Growth Factor Beta Receptor Binding R-SMAD Binding Protein Targeting To Vacuole SMAD Binding Establishment Of Protein Localization To Vacuole Ketohexokinase Activity Engulfment Of Target By Autophagosome Positive Regulation Of Cell Growth Protein Localization To Vacuole Protein Kinase CK2 Complex RNA Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Vacuolar Transport Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Aggrephagy Response To Glucose Response To Sucrose Response To Carbohydrate Response To Monosaccharide Response To Disaccharide Fructose Binding Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Homomeric SMAD Protein Complex Odontoblast Differentiation Paraxial Mesoderm Morphogenesis Mesoderm Morphogenesis Regulation Of BMP Signaling Pathway SMAD Protein Complex Pericardium Development Trophoblast Cell Migration LIM Domain Binding Activin Receptor Binding RNA Polymerase I General Transcription Initiation Factor Activity Blastocyst Growth Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Heteromeric SMAD Protein Complex Substrate Localization To Autophagosome Post-mRNA Release Spliceosomal Complex Protein Targeting Determination Of Left/right Asymmetry In Lateral Mesoderm RNA Polymerase I Core Promoter Sequence-specific DNA Binding Response To Fructose Embryonic Foregut Morphogenesis RNA Polymerase I Preinitiation Complex Assembly
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