LDB2 and DGCR6L

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		LDB2	DGCR6L
Name		LIM domain binding 2	DiGeorge syndrome critical region gene 6 like
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Plasma Membrane Cell Leading Edge	Nucleus
	Molecular Function	Transcription Coregulator Activity Protein Binding Enzyme Binding LIM Domain Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Hair Follicle Development Nervous System Development Epithelial Structure Maintenance Regulation Of Cell Migration Somatic Stem Cell Population Maintenance Regulation Of Kinase Activity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Transcription By RNA Polymerase II	None
GWAS		Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429 ) Glucocorticoid receptor gene expression in B-cell precursor acute lymphoblastic leukaemia ( 33002292 ) Liver fibrosis (total hepatic collagen content) ( 32953199 ) Number of sexual partners ( 30643258 ) QT interval ( 23534349 ) Rhegmatogenous retinal detachment ( 23585552 ) Systemic juvenile idiopathic arthritis ( 27927641 ) Waist circumference ( 28552196 )	No GWAS studies recorded
Interacting Genes		31 interacting genes: C14orf119 CETN3 DGCR6L EGLN3 EPM2AIP1 EXOC3L1 GGACT GRIK1 HDAC7 ISL1 LHX3 LHX4 LHX8 LHX9 LMO1 LMO2 LMO3 LMO4 LNX1 NTAQ1 PSMB1 RASIP1 RILP RLIM SDCBP SMARCD1 SSBP2 SSBP3 SSBP4 TSNAX TTC19	28 interacting genes: ADAMTSL4 ATN1 AVPI1 CMTM4 DEUP1 DTNBP1 GATA1 GGA1 HMG20A INIP KCNRG KRT15 KRT19 KRT31 LDB2 LRCH3 LZTS2 MBIP MID2 NAB2 NECAB2 PAK4 POU2AF1 PPP1R13B RIMBP3 SPTA1 ZNF446 ZNF620
Entrez ID		9079	85359
HPRD ID		16022	16800
Ensembl ID		ENSG00000169744	ENSG00000128185
Uniprot IDs		B7Z6D0 E9PFI4 G5E9Y7 O43679	Q9BY27
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Spinal Cord Motor Neuron Cell Fate Specification Cell Differentiation In Spinal Cord Regulation Of Transcription By RNA Polymerase II Medial Motor Column Neuron Differentiation Neuron Fate Specification DNA-binding Transcription Factor Binding Motor Neuron Axon Guidance Nucleus Neuron Projection Guidance Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Neuron Differentiation Axon Guidance Positive Regulation Of Transcription By RNA Polymerase II Single-stranded DNA Binding Transcription Regulator Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Transcription Coactivator Activity Spinal Cord Association Neuron Differentiation Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cell Fate Specification Positive Regulation Of Nucleobase-containing Compound Metabolic Process Metal Ion Binding Spinal Cord Motor Neuron Differentiation Regulation Of Metabolic Process Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Macromolecule Biosynthetic Process BHLH Transcription Factor Binding Regulation Of Gene Expression Pituitary Gland Development Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Neuron Projection Development Interleukin-5 Receptor Complex Prechordal Plate Formation Midbrain-hindbrain Boundary Initiation Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Dorsal Spinal Cord Interneuron Anterior Axon Guidance Gamma-glutamylaminecyclotransferase Activity Positive Regulation Of Macromolecule Metabolic Process Central Nervous System Neuron Differentiation Transcription Coregulator Binding	Structural Constituent Of Cytoskeleton Structural Constituent Of Skin Epidermis Cytoskeleton Organization