LDB2 and GGACT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LDB2	GGACT
Description		LIM domain binding 2	gamma-glutamylamine cyclotransferase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Plasma Membrane Cell Leading Edge	Cytosol Extracellular Exosome
	Molecular Function	Transcription Coregulator Activity Protein Binding Enzyme Binding LIM Domain Binding	Protein Binding Lyase Activity Gamma-glutamylaminecyclotransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Hair Follicle Development Nervous System Development Epithelial Structure Maintenance Regulation Of Cell Migration Somatic Stem Cell Population Maintenance Regulation Of Kinase Activity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Transcription By RNA Polymerase II	Modified Amino Acid Catabolic Process
Pathways
Drugs			Formic acid
Diseases
GWAS		Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) Glucocorticoid receptor gene expression in B-cell precursor acute lymphoblastic leukaemia ( 33002292) Liver fibrosis (total hepatic collagen content) ( 32953199) Number of sexual partners ( 30643258) QT interval ( 23534349) Rhegmatogenous retinal detachment ( 23585552) Systemic juvenile idiopathic arthritis ( 27927641) Waist circumference ( 28552196)	Refractive error ( 32231278) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		31 interacting genes: C14orf119 CETN3 DGCR6L EGLN3 EPM2AIP1 EXOC3L1 GGACT GRIK1 HDAC7 ISL1 LHX3 LHX4 LHX8 LHX9 LMO1 LMO2 LMO3 LMO4 LNX1 NTAQ1 PSMB1 RASIP1 RILP RLIM SDCBP SMARCD1 SSBP2 SSBP3 SSBP4 TSNAX TTC19	3 interacting genes: LDB2 PLAAT5 ZBED1
Entrez ID		9079	87769
HPRD ID		16022	14263
Ensembl ID		ENSG00000169744	ENSG00000134864
Uniprot IDs		B7Z6D0 E9PFI4 G5E9Y7 O43679	Q9BVM4
PDB IDs			3JUB 3JUC 3JUD
Enriched GO Terms of Interacting Partners?		Spinal Cord Motor Neuron Cell Fate Specification Cell Differentiation In Spinal Cord Regulation Of Transcription By RNA Polymerase II Medial Motor Column Neuron Differentiation Neuron Fate Specification DNA-binding Transcription Factor Binding Motor Neuron Axon Guidance Nucleus Neuron Projection Guidance Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Neuron Differentiation Axon Guidance Positive Regulation Of Transcription By RNA Polymerase II Single-stranded DNA Binding Transcription Regulator Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Transcription Coactivator Activity Spinal Cord Association Neuron Differentiation Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cell Fate Specification Positive Regulation Of Nucleobase-containing Compound Metabolic Process Metal Ion Binding Spinal Cord Motor Neuron Differentiation Regulation Of Metabolic Process Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Macromolecule Biosynthetic Process BHLH Transcription Factor Binding Regulation Of Gene Expression Pituitary Gland Development Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Neuron Projection Development Interleukin-5 Receptor Complex Prechordal Plate Formation Midbrain-hindbrain Boundary Initiation Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Dorsal Spinal Cord Interneuron Anterior Axon Guidance Gamma-glutamylaminecyclotransferase Activity Positive Regulation Of Macromolecule Metabolic Process Central Nervous System Neuron Differentiation Transcription Coregulator Binding	Transcription Coregulator Activity Protein Autosumoylation LIM Domain Binding N-acylphosphatidylethanolamine Metabolic Process N-acyltransferase Activity SUMO Ligase Activity Host-mediated Suppression Of Viral Genome Replication
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