LDB2 and ISL1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		LDB2	ISL1
Gene Name		LIM domain binding 2	ISL LIM homeobox 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion
	Molecular Function	Transcription Cofactor Activity Enzyme Binding LIM Domain Binding	RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity Enhancer Sequence-specific DNA Binding Chromatin Binding Zinc Ion Binding Ligand-dependent Nuclear Receptor Binding Estrogen Receptor Binding BHLH Transcription Factor Binding
	Biological Process	Hair Follicle Development Epithelial Structure Maintenance Somatic Stem Cell Maintenance Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Crest Cell Migration Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Vascular Endothelial Growth Factor Production Spinal Cord Motor Neuron Cell Fate Specification Spinal Cord Motor Neuron Differentiation Visceral Motor Neuron Differentiation Trigeminal Nerve Development Pituitary Gland Development Pancreas Development Axon Regeneration Retinal Ganglion Cell Axon Guidance Positive Regulation Of Insulin Secretion Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Fate Specification Mesenchymal Cell Differentiation Sensory System Development Peripheral Nervous System Neuron Axonogenesis Negative Regulation Of Inflammatory Response Ventricular Cardiac Muscle Tissue Morphogenesis Pharyngeal System Development Cardiac Muscle Cell Myoblast Differentiation Innervation Atrial Septum Morphogenesis Cardiac Cell Fate Determination Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Granulocyte Colony-stimulating Factor Production Negative Regulation Of Protein Homodimerization Activity Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Macrophage Colony-stimulating Factor Production
Pathways			Peptide hormone metabolism Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS		QT interval ( 23534349) Rhegmatogenous retinal detachment ( 23585552)	Dental caries ( 23259602)
Protein-Protein Interactions		12 interactors: ISL1 LHX4 LHX9 LMO3 LMO4 RASIP1 RILP RLIM SSBP2 SSBP3 SSBP4 TSNAX	20 interactors: APP CDK6 CDKN2B ESR1 ISL2 KDM1A LDB1 LDB2 LHX1 LHX3 LHX4 LMO2 LMX1A NR2F1 PECR RELA RLIM SMAD3 SSBP4 ZNF511
Entrez ID		9079	3670
HPRD ID		16022	02650
Ensembl ID		ENSG00000169744	ENSG00000016082
Uniprot IDs		B7Z2D3 E9PFI4 G5E9Y7 O43679	P61371
PDB IDs
Enriched GO Terms of Interacting Partners?		Spinal Cord Motor Neuron Differentiation Ventral Spinal Cord Development Cell Differentiation In Spinal Cord Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Spinal Cord Development Regulation Of Gene Expression Anatomical Structure Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Regulation Of Metabolic Process Neural Tube Development Motor Neuron Axon Guidance Central Nervous System Neuron Differentiation Negative Regulation Of Cellular Metabolic Process Tissue Morphogenesis RNA Metabolic Process Tube Development Multicellular Organismal Development Cell Differentiation Nervous System Development Transcription, DNA-templated Gene Expression RNA Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Gonad Morphogenesis Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Midbrain-hindbrain Boundary Initiation Prechordal Plate Formation Random Inactivation Of X Chromosome Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Epithelial Tube Morphogenesis Tissue Development Cardiac Septum Development Axon Guidance Developmental Process Central Nervous System Development System Development Tube Morphogenesis Positive Regulation Of Granulocyte Colony-stimulating Factor Production Positive Regulation Of Macrophage Colony-stimulating Factor Production Medial Motor Column Neuron Differentiation Positive Regulation Of Anterior Head Development Neural Tube Closure Epithelium Development Negative Regulation Of Transcription, DNA-templated	Organ Development Positive Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Cell Differentiation Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process System Development Cell Differentiation Gene Expression Central Nervous System Development Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Differentiation Multicellular Organismal Development Anatomical Structure Development Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Central Nervous System Neuron Differentiation Regulation Of Erythrocyte Differentiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Developmental Process Forebrain Development Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Brain Development Biosynthetic Process Generation Of Neurons Head Development Cellular Nitrogen Compound Metabolic Process Ventral Spinal Cord Development Positive Regulation Of Metabolic Process Neurogenesis Cell Differentiation In Spinal Cord Nervous System Development Response To External Stimulus Axon Guidance Nitrogen Compound Metabolic Process
Tagcloud ?		ablated abundant belong belongs brdu crypt endoderm endodermal gut homeobox intestine isl1 isl2 islet1 ldb1 lhx lhx1 lim lineages lmx1a lmx1b mesodermal obligatory patterning prominently quiescent terminally tracing	3f8 achieving antimouse b4galnt1 binary bm concordance enrollment gd2 immunoglobulin immunotherapy individualize individually kaplan killer meier missing mrd multivariable neuroblastoma os pfs phox2b postmrd postmrdsum predictive remission sum univariable
Tagcloud (Difference) ?		ablated abundant belong belongs brdu crypt endoderm endodermal gut homeobox intestine isl2 islet1 ldb1 lhx lhx1 lim lineages lmx1a lmx1b mesodermal obligatory patterning prominently quiescent terminally tracing	3f8 achieving antimouse b4galnt1 binary bm concordance enrollment gd2 immunoglobulin immunotherapy individualize individually kaplan killer meier missing mrd multivariable neuroblastoma os pfs phox2b postmrd postmrdsum predictive remission sum univariable
Tagcloud (Intersection) ?		isl1