LHX9 and KHK

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		LHX9	KHK
Description		LIM homeobox 9	ketohexokinase
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GO Annotations	Cellular Component	Chromatin Nucleus	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Ketohexokinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Fructose Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Male Gonad Development Female Gonad Development Neuron Differentiation Gonad Morphogenesis Negative Regulation Of DNA-templated Transcription Dorsal Spinal Cord Interneuron Anterior Axon Guidance	Fructose Metabolic Process Response To Sucrose Response To Glucose Response To Fructose Response To Zinc Ion Response To Insulin Carbohydrate Phosphorylation Regulation Of Glycogen Metabolic Process
Pathways		Regulation of expression of SLITs and ROBOs	Essential fructosuria Fructose catabolism
Drugs
Diseases
GWAS		General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Self-reported risk-taking behaviour ( 30181555) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		8 interacting genes: CSNK2A1 CWF19L2 IGFN1 KHK LDB2 SMAD2 SMURF1 UBTFL1	4 interacting genes: APPBP2 GLP1R LHX2 LHX9
Entrez ID		56956	3795
HPRD ID		07299	11774
Ensembl ID		ENSG00000143355	ENSG00000138030
Uniprot IDs		H0YL54 Q9NQ69	A0A140VJM6 C9JDL1 P50053
PDB IDs		2DMQ	2HLZ 2HQQ 2HW1 3B3L 3NBV 3NBW 3NC2 3NC9 3NCA 3Q92 3QA2 3QAI 3RO4 5WBM 5WBO 5WBP 5WBQ 5WBR 5WBZ 6UL7 6W0N 6W0W 6W0X 6W0Y 6W0Z 8OME 8OMF 8OMJ 8OMK 8UG1 8UG3 9FHD 9FHE
Enriched GO Terms of Interacting Partners?		Protein Targeting To Vacuole Involved In Autophagy I-SMAD Binding Transforming Growth Factor Beta Receptor Binding R-SMAD Binding Protein Targeting To Vacuole SMAD Binding Establishment Of Protein Localization To Vacuole Ketohexokinase Activity Engulfment Of Target By Autophagosome Positive Regulation Of Cell Growth Protein Localization To Vacuole Protein Kinase CK2 Complex RNA Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Vacuolar Transport Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Aggrephagy Response To Glucose Response To Sucrose Response To Carbohydrate Response To Monosaccharide Response To Disaccharide Fructose Binding Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Homomeric SMAD Protein Complex Odontoblast Differentiation Paraxial Mesoderm Morphogenesis Mesoderm Morphogenesis Regulation Of BMP Signaling Pathway SMAD Protein Complex Pericardium Development Trophoblast Cell Migration LIM Domain Binding Activin Receptor Binding RNA Polymerase I General Transcription Initiation Factor Activity Blastocyst Growth Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Heteromeric SMAD Protein Complex Substrate Localization To Autophagosome Post-mRNA Release Spliceosomal Complex Protein Targeting Determination Of Left/right Asymmetry In Lateral Mesoderm RNA Polymerase I Core Promoter Sequence-specific DNA Binding Response To Fructose Embryonic Foregut Morphogenesis RNA Polymerase I Preinitiation Complex Assembly	Glucagon-like Peptide 1 Receptor Activity Gonad Morphogenesis Dorsal Spinal Cord Interneuron Anterior Axon Guidance Spinal Cord Interneuron Axon Guidance Glucagon Receptor Activity Interneuron Axon Guidance Neuron Projection Guidance Axon Guidance Response To Psychosocial Stress Maintenance Of Epithelial Cell Apical/basal Polarity Telencephalon Regionalization Anterior/posterior Axon Guidance Post-translational Protein Targeting To Membrane, Translocation Cellular Response To Glucagon Stimulus Neuron Differentiation RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Activation Of Adenylate Cyclase Activity Maintenance Of Cell Polarity Positive Regulation Of Lyase Activity Positive Regulation Of Adenylate Cyclase Activity Response To Glucagon Sequence-specific DNA Binding Neuron Projection Development Cul2-RING Ubiquitin Ligase Complex Positive Regulation Of Cyclase Activity Intracellular Protein Transport Olfactory Bulb Development Female Gonad Development
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