LDB2 and LHX8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LDB2	LHX8
Description		LIM domain binding 2	LIM homeobox 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Plasma Membrane Cell Leading Edge	Chromatin Nucleus
	Molecular Function	Transcription Coregulator Activity Protein Binding Enzyme Binding LIM Domain Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Hair Follicle Development Nervous System Development Epithelial Structure Maintenance Regulation Of Cell Migration Somatic Stem Cell Population Maintenance Regulation Of Kinase Activity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Forebrain Neuron Development Neuron Differentiation Response To Ethanol
Pathways
Drugs
Diseases
GWAS		Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) Glucocorticoid receptor gene expression in B-cell precursor acute lymphoblastic leukaemia ( 33002292) Liver fibrosis (total hepatic collagen content) ( 32953199) Number of sexual partners ( 30643258) QT interval ( 23534349) Rhegmatogenous retinal detachment ( 23585552) Systemic juvenile idiopathic arthritis ( 27927641) Waist circumference ( 28552196)
Interacting Genes		31 interacting genes: C14orf119 CETN3 DGCR6L EGLN3 EPM2AIP1 EXOC3L1 GGACT GRIK1 HDAC7 ISL1 LHX3 LHX4 LHX8 LHX9 LMO1 LMO2 LMO3 LMO4 LNX1 NTAQ1 PSMB1 RASIP1 RILP RLIM SDCBP SMARCD1 SSBP2 SSBP3 SSBP4 TSNAX TTC19	26 interacting genes: - ABI2 ATF2 ATF6B AXIN1 BANP CCHCR1 CRK CSNK2A1 EFS FIGLA FOSL2 FOXN1 GINS4 KLF3 KRT85 LDB2 NEDD9 NUTM1 PLCG2 PRPF31 SCYL3 SUV39H1 TBC1D1 TBC1D22B ZBTB24
Entrez ID		9079	431707
HPRD ID		16022	17275
Ensembl ID		ENSG00000169744	ENSG00000162624
Uniprot IDs		B7Z6D0 E9PFI4 G5E9Y7 O43679	Q68G74
PDB IDs
Enriched GO Terms of Interacting Partners?		Spinal Cord Motor Neuron Cell Fate Specification Cell Differentiation In Spinal Cord Regulation Of Transcription By RNA Polymerase II Medial Motor Column Neuron Differentiation Neuron Fate Specification DNA-binding Transcription Factor Binding Motor Neuron Axon Guidance Nucleus Neuron Projection Guidance Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Neuron Differentiation Axon Guidance Positive Regulation Of Transcription By RNA Polymerase II Single-stranded DNA Binding Transcription Regulator Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Transcription Coactivator Activity Spinal Cord Association Neuron Differentiation Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cell Fate Specification Positive Regulation Of Nucleobase-containing Compound Metabolic Process Metal Ion Binding Spinal Cord Motor Neuron Differentiation Regulation Of Metabolic Process Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Macromolecule Biosynthetic Process BHLH Transcription Factor Binding Regulation Of Gene Expression Pituitary Gland Development Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Neuron Projection Development Interleukin-5 Receptor Complex Prechordal Plate Formation Midbrain-hindbrain Boundary Initiation Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Dorsal Spinal Cord Interneuron Anterior Axon Guidance Gamma-glutamylaminecyclotransferase Activity Positive Regulation Of Macromolecule Metabolic Process Central Nervous System Neuron Differentiation Transcription Coregulator Binding	NK T Cell Differentiation Nucleus Protein Tyrosine Kinase Binding Response To Endothelin Cellular Response To Endothelin RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Cell Development Signaling Adaptor Activity Response To Yeast Epigenetic Programming In The Zygotic Pronuclei DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Cellular Developmental Process Regulation Of Transcription By RNA Polymerase II
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