CDK5RAP1 and EXOSC3

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CDK5RAP1	EXOSC3
Gene Name		CDK5 regulatory subunit associated protein 1	exosome component 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytoplasm	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin
	Molecular Function	Transferase Activity Protein Kinase Binding Protein Complex Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	TRNA Modification Brain Development Regulation Of Neuron Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Gene Expression Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing
Pathways			Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CDK5 CDK5R1 EXOSC3 EXOSC5	8 interactors: APP ATP5D CDK5RAP1 EXOSC4 EXOSC5 EXOSC8 EXOSC9 KHSRP
Entrez ID		51654	51010
HPRD ID		12189	16220
Ensembl ID		ENSG00000101391	ENSG00000107371
Uniprot IDs		Q53H36 Q96SZ6	Q9NQT5 Q9NYS3
PDB IDs			2NN6
Enriched GO Terms of Interacting Partners?		Serine Phosphorylation Of STAT3 Protein Serine Phosphorylation Of STAT Protein DNA Deamination Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Negative Regulation Of Axon Extension Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Protein Targeting To Membrane Regulation Of Dendritic Spine Morphogenesis Layer Formation In Cerebral Cortex Cerebral Cortex Radial Glia Guided Migration Peptidyl-threonine Phosphorylation Regulation Of Dendritic Spine Development Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Neuron Apoptotic Process Cerebral Cortex Radially Oriented Cell Migration Negative Regulation Of Axonogenesis Glial Cell Migration Regulation Of Axon Extension Regulation Of Dendrite Morphogenesis Hippocampus Development Positive Regulation Of Neuron Death DNA Modification Negative Regulation Of Developmental Growth Cerebral Cortex Cell Migration Regulation Of JAK-STAT Cascade Limbic System Development Regulation Of Cell Cycle Arrest Negative Regulation Of Cell Morphogenesis Involved In Differentiation Telencephalon Cell Migration Forebrain Cell Migration Regulation Of Dendrite Development RNA Phosphodiester Bond Hydrolysis Cerebellum Development Peptidyl-serine Phosphorylation Negative Regulation Of Neuron Projection Development Metencephalon Development RRNA Processing Regulation Of Cell Size RRNA Metabolic Process Negative Regulation Of Cell Projection Organization Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Cell Growth Regulation Of Axonogenesis MRNA Catabolic Process Cerebral Cortex Development Positive Regulation Of Intracellular Protein Transport Neuron Migration Hindbrain Development Superior Olivary Nucleus Maturation	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Catabolic Process MRNA Metabolic Process RRNA Processing RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Aromatic Compound Catabolic Process NcRNA Metabolic Process Ribosome Biogenesis Nuclear MRNA Surveillance Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex Biogenesis DNA Deamination RNA Surveillance Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Catabolic Process Cellular Nitrogen Compound Metabolic Process RNA Phosphodiester Bond Hydrolysis RNA Metabolic Process Nitrogen Compound Metabolic Process Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Gene Expression DNA Modification Synaptic Growth At Neuromuscular Junction Positive Regulation Of Cell Growth Regulation Of Growth Collateral Sprouting In Absence Of Injury Cellular Metabolic Process Defense Response To Virus Nuclear Polyadenylation-dependent RRNA Catabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Positive Regulation Of Growth Neuron Remodeling Regulation Of MiRNA Metabolic Process Histone MRNA Catabolic Process Response To Virus Immune System Process RRNA Catabolic Process Regulation Of Cell Growth Mitochondrial ATP Synthesis Coupled Proton Transport Maturation Of 5.8S RRNA
Tagcloud ?		acetyl arrested caspase converts cysteine deficiency deficient g2 i6a incubated interfering iso isopentenyladenosine jnk jun mcf methylthio ms2i6a n6 nac pentenyladenosine phospho pretreatment ros sirna sp600125 synthetically upregulated world	aligned amenable avenues baz2a bioinformatic candidates cdk13 chem dapk1 digest dilution dst hdms hierarchical inhbe kat2b kif20b linkages noninvasive pancreatic proteomics resectable silva smc1b spag5 synapt tryptic unsupervised urgent
Tagcloud (Difference) ?		acetyl arrested caspase converts cysteine deficiency deficient g2 i6a incubated interfering iso isopentenyladenosine jnk jun mcf methylthio ms2i6a n6 nac pentenyladenosine phospho pretreatment ros sirna sp600125 synthetically upregulated world	aligned amenable avenues baz2a bioinformatic candidates cdk13 chem dapk1 digest dilution dst hdms hierarchical inhbe kat2b kif20b linkages noninvasive pancreatic proteomics resectable silva smc1b spag5 synapt tryptic unsupervised urgent
Tagcloud (Intersection) ?