CDK5RAP1 and EXOSC5

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		CDK5RAP1	EXOSC5
Description		CDK5RAP1 mitochondrial tRNA methylthiotransferase	exosome component 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex
	Molecular Function	Catalytic Activity Transferase Activity Protein Kinase Binding Methylthiotransferase Activity TRNA-2-methylthio-N(6)-dimethylallyladenosine(37) Synthase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	3'-5'-RNA Exonuclease Activity DNA Binding RNA Binding RNA Exonuclease Activity Protein Binding
	Biological Process	TRNA Modification Brain Development TRNA Processing RNA Modification TRNA Methylthiolation Regulation Of Neuron Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Translational Fidelity Regulation Of Protein Metabolic Process Positive Regulation Of Mitochondrial Translation Mitochondrial TRNA Modification	RRNA Processing RNA Processing RNA Catabolic Process MRNA Catabolic Process RRNA Catabolic Process U4 SnRNA 3'-end Processing DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Poly(A)-dependent SnoRNA 3'-end Processing
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) Hip circumference adjusted for BMI ( 25673412 34021172) Mean corpuscular volume ( 32888494)	Appendicular lean mass ( 33097823)
Interacting Genes		4 interacting genes: CDK5 CDK5R1 EXOSC3 EXOSC5	82 interacting genes: ACOT11 ADAMTSL4 BIRC2 BORCS6 CALCOCO2 CCDC88B CDK5RAP1 CEP55 CPSF7 DAAM2 DDIT4L DHRS2 DIS3 DMRTB1 DOCK8 EFHC2 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 FH FHL3 GOLGA2 HOXC4 IKZF3 KCTD13 KIAA1217 KRT13 KRT27 KRT31 KRT34 KRT35 LCA5L LIPG LRMDA LSM3 LSM5 LZTS2 MEOX2 MPHOSPH6 MTMR3 MTREX MYLIP NKAPD1 NMI NUP210 PA2G4 PALS2 PEG10 PICK1 PIH1D2 PKM POLR2L PRDM6 PTEN REL SFPQ SH3GLB1 SH3GLB2 SHISA6 SNW1 SPTA1 TEX11 TFIP11 TLE5 TNFAIP1 TRIB3 TRIM54 TRIM62 YTHDF3 ZFP90 ZMAT1 ZNF420 ZNF558 ZNF620 ZNF655 ZNF792
Entrez ID		51654	56915
HPRD ID		12189	16222
Ensembl ID		ENSG00000101391	ENSG00000077348
Uniprot IDs		A0A0S2Z592 A0A0S2Z5J9 Q53H36 Q96SZ6	Q9NQT4
PDB IDs			2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Protein Kinase 5 Complex Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity DNA Deamination Nucleolar Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process Layer Formation In Cerebral Cortex SnRNA 3'-end Processing Positive Regulation Of Protein Targeting To Membrane DNA Modification Ionotropic Glutamate Receptor Binding 3'-5'-RNA Exonuclease Activity Regulation Of Protein Targeting To Membrane SnRNA Processing Nuclear RNA Surveillance RNA Surveillance Regulation Of Dendritic Spine Morphogenesis Oligodendrocyte Differentiation Cyclin-dependent Protein Kinase Holoenzyme Complex SnRNA Metabolic Process Cerebellum Development Euchromatin Glial Cell Development Neuron Differentiation Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Hippocampus Development Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Ventral Spinal Cord Interneuron Fate Determination Type B Pancreatic Cell Fate Commitment Neuromuscular Junction RNA 3'-end Processing Microtubule Cytoskeleton Organization Acetylcholine Receptor Activator Activity Glial Cell Differentiation Cell Projection Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Superior Olivary Nucleus Maturation Nuclear-transcribed MRNA Catabolic Process Regulation Of Developmental Process ErbB-2 Class Receptor Binding Negative Regulation Of Synaptic Plasticity Cerebellar Cortex Formation Epithelial Cell Development Spinal Cord Oligodendrocyte Cell Fate Specification	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing RRNA 3'-end Processing TRNA Decay Nuclear MRNA Surveillance Nuclear RNA Surveillance RNA Surveillance RRNA Processing SnRNA Metabolic Process RRNA Metabolic Process RNA 3'-end Processing RNA Processing SnRNA 3'-end Processing CUT Catabolic Process RNA Catabolic Process 3'-5'-RNA Exonuclease Activity RRNA Catabolic Process SnRNA Processing MRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nucleobase-containing Compound Catabolic Process RNA Metabolic Process Sno(s)RNA Metabolic Process Exoribonuclease Complex TRNA Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Structural Constituent Of Skin Epidermis Cytosol Intermediate Filament Organization Nucleic Acid Metabolic Process RNA Binding Macromolecule Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Nucleolus Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Protein Polyubiquitination
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