PA2G4 and ERBB3

Number of citations of the paper that reports this interaction (PMID 10682683)
39

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PA2G4	ERBB3
Gene Name		proliferation-associated 2G4, 38kDa	erb-b2 receptor tyrosine kinase 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Ribonucleoprotein Complex Extracellular Vesicular Exosome	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Receptor Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding	Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Growth Factor Binding Protein Tyrosine Kinase Activator Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Transcription, DNA-templated RRNA Processing Regulation Of Translation Cell Cycle Arrest Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated	Endocardial Cushion Development Protein Phosphorylation Negative Regulation Of Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Peripheral Nervous System Development Heart Development Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Signal Transduction Schwann Cell Differentiation Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cranial Nerve Development Fc-epsilon Receptor Signaling Pathway Wound Healing Regulation Of Cell Proliferation Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Negative Regulation Of Secretion Neuron Apoptotic Process Positive Regulation Of Protein Tyrosine Kinase Activity Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Drugs
Diseases
GWAS		Vitiligo ( 22951725)	Obesity-related traits ( 23251661) Type 1 diabetes ( 19430480 18198356 17554260 17554300 18978792) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 22951725)
Protein-Protein Interactions		20 interactors: AR ATR ERBB3 EXOSC5 FUS HDAC2 HMGA1 HMGA2 IKBKG LIG4 MTOR PRKCA PRKCB PRKCG RB1 RNF20 SIN3A SUMO4 TERF1 UBC	66 interactors: ABL1 ABL2 AGTR2 BCAR3 CD82 CDK5 CHN2 CRK CRKL DAB1 DAPP1 EGF EGFR EGR1 ERBB2 ERBB4 FER FGFR1 FLNA FLYWCH1 GRB2 GRB7 HCK HDAC6 IL6ST ITK JAK2 JAK3 MUC1 NCK1 NCK2 NEDD4 NRG1 NRG2 ODF2L PA2G4 PIK3R1 PIK3R2 PIK3R3 PLCG1 PTGES3 PTK2 PTK2B PTK6 RASA1 RASA4 RGS4 RIN1 RNF41 RPN1 SH2B3 SH2D1A SHC1 SHC3 SOS1 SRC SYK TNS2 TNS3 TNS4 TXK VAV1 VAV2 VAV3 ZAP70 ZNF207
Entrez ID		5036	2065
HPRD ID		03685	01820
Ensembl ID		ENSG00000170515	ENSG00000065361
Uniprot IDs		Q9UQ80	P21860
PDB IDs		2Q8K 3J2I	1M6B 2L9U 3KEX 3LMG 3P11 4LEO
Enriched GO Terms of Interacting Partners?		Chromatin Modification Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Chromatin Organization Chromosome Organization Regulation Of Apoptotic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Response To Stress Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Cellular Metabolic Process DNA Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Signaling Negative Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune System Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Cell Aging Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Histone Modification Histone H3-T6 Phosphorylation Oncogene-induced Cell Senescence Regulation Of Mitotic Cell Cycle Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Cycle Process Cell Cycle Checkpoint Regulation Of Cell Proliferation Nitrogen Compound Metabolic Process Cellular Response To Stress	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Cell Communication Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction Signaling Regulation Of Signaling Cell Migration Signal Transduction Immune Response Regulation Of Immune Response Peptidyl-tyrosine Autophosphorylation Cell Motility Locomotion Positive Regulation Of Signal Transduction Regulation Of Immune System Process Intracellular Signal Transduction Defense Response Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Immune System Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Intracellular Signal Transduction Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Cellular Response To Stimulus Regulation Of Kinase Activity Regulation Of Catalytic Activity Fc-epsilon Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Cell Activation Response To Growth Factor Response To Stress Positive Regulation Of Catalytic Activity Response To Stimulus Wound Healing Response To Organic Substance Cellular Response To Growth Factor Stimulus Regulation Of Cell Proliferation Blood Coagulation Hemostasis
Tagcloud ?		a8 acidic acting afgf agnwtpi ap8 arrested biopanning clone competed contained display erk1 fgfr1 fgfrs fibroblast g0 gtpnptl heptapeptide homology identical library named pcna peptide phage rounds suppressing tp	acquire alteration associate cascades concurrent dependence egf enhancing latent mapk mediators p42 p44 phosphotyrosine potentiates potentiating predicts prime priming progestin progestins r5020 shc shift stat5 steroid switches synergistically waf1
Tagcloud (Difference) ?		a8 acidic acting afgf agnwtpi ap8 arrested biopanning clone competed contained display erk1 fgfr1 fgfrs fibroblast g0 gtpnptl heptapeptide homology identical library named pcna peptide phage rounds suppressing tp	acquire alteration associate cascades concurrent dependence egf enhancing latent mapk mediators p42 p44 phosphotyrosine potentiates potentiating predicts prime priming progestin progestins r5020 shc shift stat5 steroid switches synergistically waf1
Tagcloud (Intersection) ?