PA2G4 and HSPA4

Number of citations of the paper that reports this interaction (PubMedID 27464702)
33

Data Source:
BioGRID (far western blotting)

		PA2G4	HSPA4
Description		proliferation-associated 2G4	heat shock protein family A (Hsp70) member 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleolus Cytoplasm Membrane Azurophil Granule Lumen Extracellular Exosome Ribonucleoprotein Complex	Nucleus Cytoplasm Cytosol Organelle Extracellular Exosome
	Molecular Function	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding Protein Binding Ubiquitin Protein Ligase Binding	Nucleotide Binding Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding ATP-dependent Protein Folding Chaperone
	Biological Process	RRNA Processing Regulation Of Translation Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription	Protein Folding Response To Unfolded Protein Protein Import Into Mitochondrial Matrix Chaperone-mediated Protein Complex Assembly
Pathways		Neutrophil degranulation	Regulation of HSF1-mediated heat shock response
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Adult body size ( 32376654) Allergic disease (asthma, hay fever or eczema) ( 29785011) Anorexia nervosa ( 28494655) Asthma ( 31619474 31959851) Asthma or allergic disease (pleiotropy) ( 29785011) Refractive error ( 32231278) Vitiligo ( 22951725)	A body shape index ( 34021172) Breast cancer ( 29059683) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) High density lipoprotein cholesterol levels ( 31928498) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Triglyceride levels ( 31928498 32203549 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		26 interacting genes: AR ATR CEBPA EIF2AK2 ERBB3 ESR1 EXOSC5 HDAC2 HMGA1 HMGA2 HSPA4 IKBKG LIG4 MTOR OGT PRKCA PRKCB PRKCG PRKN RB1 RBFOX2 RNF20 SIN3A STUB1 SUMO4 TERF1	72 interacting genes: ABCC2 AGTRAP APPBP2 BAG1 BAG2 BRMS1 CALM1 CD40 CDC73 CDKN2A CEBPA CSNK1A1 CSNK2A1 DDIT4 DNAJB2 DUSP1 EGFR ESR1 FANCC FES FKBP4 GATA1 GRPEL2 GSK3B GZMA HAP1 HDAC3 HNRNPD HSF2 HSPB1 HSPBP1 IKBKG KPNA2 KRT18 MUC1 NAA10 NEDD8 NFKB1 NR3C2 OLR1 PA2G4 PHLDA1 POU6F2 PPP1CA PRKACA PRKCB PRKCD PRKCG PRSS23 PSMD10 PTEN RAF1 RAP1A REL RELA SENP8 SGTA SIRPA SMAD3 ST13 STIP1 STK4 STUB1 SUGT1 TERT TOMM40 TRAF6 TRIM32 TTC1 UBE2L3 UBE2M UBE3A
Entrez ID		5036	3308
HPRD ID		03685	09025
Ensembl ID		ENSG00000170515	ENSG00000170606
Uniprot IDs		Q9UQ80	P34932
PDB IDs		2Q8K 3J2I 6CHT 6LSR 6SXO 6WM8 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 8K2C 8XSX 8XSY 8XSZ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Intracellular Signal Transduction Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Macromolecule Metabolic Process Enzyme Binding Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Chromatin Organization Positive Regulation Of Proteolysis Chromatin Remodeling Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Proteolysis Regulation Of RNA Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signal Transduction Cellular Response To Stress Cellular Response To Dopamine Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Response To Dopamine Response To Hormone Regulation Of Cell Population Proliferation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process	Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Cytosol Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of Primary Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Protein Catabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Post-translational Protein Modification Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Response To Lipid Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Post-translational Protein Modification Intracellular Signaling Cassette Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cellular Response To Oxygen-containing Compound Regulation Of Protein Stability Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Lipid Negative Regulation Of Metabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Apoptotic Signaling Pathway
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