DPYSL5 and FBN2

Data Source: HiPPIP (Novel)

		DPYSL5	FBN2
Name		dihydropyrimidinase like 5	fibrillin 2
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Dendrite Protein-containing Complex Neuronal Cell Body Synapse Glutamatergic Synapse	Microfibril Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Dihydropyrimidinase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides	Hormone Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity
	Biological Process	Pyrimidine Nucleobase Catabolic Process Signal Transduction Nervous System Development Axon Guidance Neuron Differentiation Negative Regulation Of Dendrite Morphogenesis	Placenta Development Glucose Metabolic Process Signal Transduction Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization Limb Morphogenesis Sequestering Of TGFbeta In Extracellular Matrix Glucose Homeostasis Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Embryonic Eye Morphogenesis Bone Trabecula Formation Regulation Of Trophoblast Cell Migration
Pathways		CRMPs in Sema3A signaling	Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		None	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		None	Congenital contractural arachnodactyly (CCA) ; Beals syndrome
GWAS		Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Fasting blood glucose ( 22581228 ) Fasting blood glucose (BMI interaction) ( 22581228 ) Fasting glucose ( 34059833 ) Fasting insulin ( 34059833 ) Obesity-related traits ( 23251661 ) Reflection (response to stress) ( 30886212 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Urate levels ( 31578528 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 ) White blood cell count ( 32888494 )	Atrial fibrillation ( 29892015 ) Beard thickness ( 26926045 ) Brain morphology (MOSTest) ( 32665545 ) Breastfeeding duration ( 25475840 ) Central corneal thickness ( 32528159 ) Cortical surface area (MOSTest) ( 32665545 ) Diastolic blood pressure ( 27841878 ) Heel bone mineral density ( 30598549 ) Height ( 21998595 31562340 ) Heschl's gyrus morphology ( 25130324 ) Hip circumference adjusted for BMI ( 34021172 ) Intraocular pressure ( 29617998 ) Medication use (beta blocking agents) ( 31015401 ) Medication use (calcium channel blockers) ( 31015401 ) Medication use (diuretics) ( 31015401 ) Multiple system atrophy ( 27629089 ) Night sleep phenotypes ( 27126917 ) Obesity (extreme) ( 19553259 ) Pulse pressure ( 30578418 27841878 ) Refractive error ( 32231278 ) Response to fenofibrate (total cholesterol levels) ( 27002377 ) Severe aplastic anemia ( 32004448 ) Subcortical volume (MOSTest) ( 32665545 ) Systemic lupus erythematosus ( 32771030 ) Systolic blood pressure ( 30578418 28135244 27841878 ) Temperament ( 22832960 ) Waist circumference adjusted for body mass index ( 34021172 )
Novel Interactors		1 novel interactors: FBN2	15 novel interactors: CMBL CSF2 DPYSL5 DUSP5 FDPS ITGA2 NDUFB6 NRG2 RNF14 SEMA3F SIRPA SLC27A6 SNRPB TRIM24 UBE2B
Interacting Genes		9 interacting genes: APPL1 CFAP161 DARS2 DPYS DPYSL2 DPYSL3 DPYSL4 FES HSPA5	8 interacting genes: ELN FBN1 LTBP1 MATN2 MFAP2 MFAP5 SMAD2 THBS1
Entrez ID		56896	2201
HPRD ID		10522	00416
Ensembl ID		ENSG00000157851	ENSG00000138829
Uniprot IDs		Q9BPU6	P35556
PDB IDs		4B90 4B91 4B92	Not available
GO Terms Enriched among Interactors		Dihydropyrimidinase Activity Pyrimidine Nucleobase Catabolic Process Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Pyrimidine Nucleobase Metabolic Process Pyrimidine-containing Compound Catabolic Process Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Pyrimidine-containing Compound Metabolic Process Filamin Binding Regulation Of Cell Motility Regulation Of Locomotion Nucleobase-containing Small Molecule Metabolic Process Phosphoprotein Binding Maintenance Of Protein Location Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Aspartate-tRNA(Asn) Ligase Activity Mitochondrial Asparaginyl-tRNA Aminoacylation Small Molecule Metabolic Process Hydrolase Activity Uracil Catabolic Process Maintenance Of Location Cerebellum Structural Organization Positive Regulation Of Macropinocytosis Aspartyl-tRNA Aminoacylation Aspartate-tRNA Ligase Activity Thymine Metabolic Process Thymine Catabolic Process Regulation Of Cell Migration Sequestering Of TGFbeta In Extracellular Matrix Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Phosphatidylinositol Binding Asparaginyl-tRNA Aminoacylation Cytoplasm CMP Catabolic Process DUMP Catabolic Process Regulation Of ATF6-mediated Unfolded Protein Response UMP Catabolic Process Catabolic Process DCMP Catabolic Process Macropinosome Positive Regulation Of Neuron Projection Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Nervous System Development Pyrimidine Ribonucleotide Catabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Pinocytosis Bone Trabecula Formation Post-translational Protein Targeting To Membrane, Translocation Adiponectin-activated Signaling Pathway	Extracellular Matrix Structural Constituent Microfibril Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Embryonic Eye Morphogenesis Embryonic Organ Morphogenesis Post-embryonic Eye Morphogenesis Fibrinogen Binding Animal Organ Morphogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Eye Morphogenesis Extracellular Matrix Constituent Conferring Elasticity Extracellular Negative Regulation Of Signal Transduction Sensory Organ Morphogenesis Endoderm Formation Extracellular Region Ubiquitin-like Protein Transferase Activity Laminin Binding Transforming Growth Factor Beta Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Adhesion Mediated By Integrin Extracellular Matrix Binding Fibronectin Binding Response To Monosaccharide Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Response To Nutrient Levels Integrin Binding Cell Migration Regulation Of Smooth Muscle Cell Proliferation Aortic Valve Morphogenesis Negative Regulation Of Developmental Process Response To Carbohydrate Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Histone H3K23ac Reader Activity