DPYSL5 and DPYSL3

Number of citations of the paper that reports this interaction (PMID 10956643)
20

Data Source:
HPRD (in vivo)

		DPYSL5	DPYSL3
Gene Name		dihydropyrimidinase-like 5	dihydropyrimidinase-like 3
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Gene Ontology Annotations	Cellular Component	Cytosol Dendrite Neuronal Cell Body	Extracellular Space Cytosol Lamellipodium Growth Cone Filamentous Actin Cell Body Exocytic Vesicle
	Molecular Function	Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides	Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides SH3 Domain Binding Chondroitin Sulfate Binding Phosphoprotein Binding
	Biological Process	Pyrimidine Nucleobase Catabolic Process Signal Transduction Nervous System Development Axon Guidance	Pyrimidine Nucleobase Catabolic Process Axon Guidance Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Response To Axon Injury Actin Filament Bundle Assembly Protein Homooligomerization Positive Regulation Of Filopodium Assembly Actin Crosslink Formation Cellular Response To Cytokine Stimulus
Pathways		Axon guidance Semaphorin interactions CRMPs in Sema3A signaling	Axon guidance Semaphorin interactions CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Fasting glucose-related traits (interaction with BMI) ( 22581228) Obesity-related traits ( 23251661)
Protein-Protein Interactions		8 interactors: APPL1 DARS2 DPYS DPYSL2 DPYSL3 DPYSL4 FES HSPA5	8 interactors: ACD CRMP1 DISC1 DPYSL2 DPYSL5 POT1 TERF1 TNIK
Entrez ID		56896	1809
HPRD ID		10522	03104
Ensembl ID		ENSG00000157851	ENSG00000113657
Uniprot IDs		Q9BPU6	Q14195 Q6DEN2 Q8IXW6
PDB IDs		4B90 4B91 4B92	4BKN
Enriched GO Terms of Interacting Partners?		Pyrimidine Nucleobase Catabolic Process Pyrimidine Nucleobase Metabolic Process Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Nucleobase-containing Small Molecule Metabolic Process Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Catabolic Process Response To External Stimulus Neuron Development Regulation Of Neuron Projection Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Mitochondrial Asparaginyl-tRNA Aminoacylation Regulation Of Protein Folding In Endoplasmic Reticulum Nervous System Development Small Molecule Metabolic Process Regulation Of Cell Projection Organization Locomotion Anatomical Structure Morphogenesis Regulation Of Neuron Differentiation Cerebellum Structural Organization Uracil Catabolic Process Movement Of Cell Or Subcellular Component Regulation Of Cell Motility Beta-alanine Metabolic Process Uracil Metabolic Process Thymine Metabolic Process Thymine Catabolic Process Generation Of Neurons Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Neurogenesis Neurogenesis Positive Regulation Of Glutamate Secretion TRNA Aminoacylation For Mitochondrial Protein Translation Cell Development Regulation Of Cell Development Regulation Of Cellular Component Organization Positive Regulation Of Neuron Projection Development Asparaginyl-tRNA Aminoacylation Protein Homooligomerization ER Overload Response	Negative Regulation Of Telomere Maintenance Via Telomerase Pyrimidine Nucleobase Catabolic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Pyrimidine Nucleobase Metabolic Process Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Telomere Assembly Telomere Capping Telomere Maintenance Positive Regulation Of Telomerase Activity Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Regulation Of Cellular Component Organization Regulation Of DNA Replication Positive Regulation Of DNA Biosynthetic Process RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Regulation Of Chromosome Organization Telomere Maintenance Via Telomere Lengthening Generation Of Neurons Neurogenesis Organelle Organization Regulation Of Neuron Projection Development Positive Regulation Of DNA Replication Axon Guidance Developmental Process Cell Projection Organization Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation Nervous System Development Regulation Of Cell Projection Organization Locomotion Axonogenesis System Development Regulation Of Neuron Differentiation Homeostatic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Transferase Activity Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Movement Of Cell Or Subcellular Component Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Formation Via Telomerase
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