DPYSL5 and DPYSL4

Number of citations of the paper that reports this interaction (PubMedID 10956643)
0

Data Source:
HPRD (in vivo)

		DPYSL5	DPYSL4
Description		dihydropyrimidinase like 5	dihydropyrimidinase like 4
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GO Annotations	Cellular Component	Cytoplasm Cytosol Dendrite Protein-containing Complex Neuronal Cell Body Synapse Glutamatergic Synapse	Cytoplasm Cytosol
	Molecular Function	Dihydropyrimidinase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides	Dihydropyrimidinase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Filamin Binding
	Biological Process	Pyrimidine Nucleobase Catabolic Process Signal Transduction Nervous System Development Axon Guidance Neuron Differentiation Negative Regulation Of Dendrite Morphogenesis	Pyrimidine Nucleobase Catabolic Process Nervous System Development
Pathways		CRMPs in Sema3A signaling	CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fasting insulin ( 34059833) Obesity-related traits ( 23251661) Reflection (response to stress) ( 30886212) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31578528) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) White blood cell count ( 32888494)	Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: APPL1 CFAP161 DARS2 DPYS DPYSL2 DPYSL3 DPYSL4 FES HSPA5	9 interacting genes: DPYSL5 PTPRO RBPMS SH3GL1 SH3GL2 SH3GL3 TRIM54 TRIP13 WEE2-AS1
Entrez ID		56896	10570
HPRD ID		10522	07463
Ensembl ID		ENSG00000157851	ENSG00000151640
Uniprot IDs		Q9BPU6	O14531
PDB IDs		4B90 4B91 4B92	5NKS
Enriched GO Terms of Interacting Partners?		Dihydropyrimidinase Activity Pyrimidine Nucleobase Catabolic Process Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Pyrimidine Nucleobase Metabolic Process Pyrimidine-containing Compound Catabolic Process Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Pyrimidine-containing Compound Metabolic Process Filamin Binding Regulation Of Cell Motility Regulation Of Locomotion Nucleobase-containing Small Molecule Metabolic Process Phosphoprotein Binding Maintenance Of Protein Location Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Aspartate-tRNA(Asn) Ligase Activity Mitochondrial Asparaginyl-tRNA Aminoacylation Small Molecule Metabolic Process Hydrolase Activity Uracil Catabolic Process Maintenance Of Location Cerebellum Structural Organization Positive Regulation Of Macropinocytosis Aspartyl-tRNA Aminoacylation Aspartate-tRNA Ligase Activity Thymine Metabolic Process Thymine Catabolic Process Regulation Of Cell Migration Sequestering Of TGFbeta In Extracellular Matrix Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Phosphatidylinositol Binding Asparaginyl-tRNA Aminoacylation Cytoplasm CMP Catabolic Process DUMP Catabolic Process Regulation Of ATF6-mediated Unfolded Protein Response UMP Catabolic Process Catabolic Process DCMP Catabolic Process Macropinosome Positive Regulation Of Neuron Projection Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Nervous System Development Pyrimidine Ribonucleotide Catabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Pinocytosis Bone Trabecula Formation Post-translational Protein Targeting To Membrane, Translocation Adiponectin-activated Signaling Pathway	Glutamatergic Synapse Negative Regulation Of Cellular Component Organization Central Nervous System Development Presynapse Regulation Of Cellular Component Organization Neuron Projection Development Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Glomerular Filtration Negative Regulation Of Retinal Ganglion Cell Axon Guidance Filtration Diaphragm Assembly Slit Diaphragm Assembly Lipid Binding Signal Transduction Endocytosis Identical Protein Binding System Development Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Blood-brain Barrier Permeability Negative Regulation Of Clathrin-dependent Endocytosis Meiotic Recombination Checkpoint Signaling MRNA CDS Binding Pre-mRNA 5'-splice Site Binding Postsynaptic Endosome
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