DPYSL5 and DPYSL4

Number of citations of the paper that reports this interaction (PMID 10956643)
20

Data Source:
HPRD (in vivo)

		DPYSL5	DPYSL4
Gene Name		dihydropyrimidinase-like 5	dihydropyrimidinase-like 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Dendrite Neuronal Cell Body	Cytosol
	Molecular Function	Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides	Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides
	Biological Process	Pyrimidine Nucleobase Catabolic Process Signal Transduction Nervous System Development Axon Guidance	Pyrimidine Nucleobase Catabolic Process Nervous System Development Axon Guidance
Pathways		Axon guidance Semaphorin interactions CRMPs in Sema3A signaling	Axon guidance Semaphorin interactions CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Fasting glucose-related traits (interaction with BMI) ( 22581228) Obesity-related traits ( 23251661)
Protein-Protein Interactions		8 interactors: APPL1 DARS2 DPYS DPYSL2 DPYSL3 DPYSL4 FES HSPA5	8 interactors: DPYSL2 DPYSL5 PTPRO RBPMS SH3GL1 SH3GL2 SH3GL3 TRIP13
Entrez ID		56896	10570
HPRD ID		10522	07463
Ensembl ID		ENSG00000157851	ENSG00000151640
Uniprot IDs		Q9BPU6	D3DRG7 O14531
PDB IDs		4B90 4B91 4B92
Enriched GO Terms of Interacting Partners?		Pyrimidine Nucleobase Catabolic Process Pyrimidine Nucleobase Metabolic Process Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Nucleobase-containing Small Molecule Metabolic Process Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Catabolic Process Response To External Stimulus Neuron Development Regulation Of Neuron Projection Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Mitochondrial Asparaginyl-tRNA Aminoacylation Regulation Of Protein Folding In Endoplasmic Reticulum Nervous System Development Small Molecule Metabolic Process Regulation Of Cell Projection Organization Locomotion Anatomical Structure Morphogenesis Regulation Of Neuron Differentiation Cerebellum Structural Organization Uracil Catabolic Process Movement Of Cell Or Subcellular Component Regulation Of Cell Motility Beta-alanine Metabolic Process Uracil Metabolic Process Thymine Metabolic Process Thymine Catabolic Process Generation Of Neurons Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Neurogenesis Neurogenesis Positive Regulation Of Glutamate Secretion TRNA Aminoacylation For Mitochondrial Protein Translation Cell Development Regulation Of Cell Development Regulation Of Cellular Component Organization Positive Regulation Of Neuron Projection Development Asparaginyl-tRNA Aminoacylation Protein Homooligomerization ER Overload Response	Pyrimidine Nucleobase Catabolic Process Axon Guidance Axonogenesis Nervous System Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Endocytosis Cell Morphogenesis Involved In Differentiation Pyrimidine Nucleobase Metabolic Process Neuron Projection Development Cell Projection Morphogenesis Anatomical Structure Development Cell Part Morphogenesis Cell Development Neuron Development Central Nervous System Development Developmental Process Cell Morphogenesis Neuron Differentiation Cell Projection Organization Slit Diaphragm Assembly Locomotion Synaptic Vesicle Transport System Development Negative Regulation Of Retinal Ganglion Cell Axon Guidance Vesicle-mediated Transport Cellular Response To Stimulus Movement Of Cell Or Subcellular Component Generation Of Neurons Multicellular Organismal Development Neurogenesis Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Glutamate Secretion Response To External Stimulus Negative Regulation Of Glomerular Filtration Establishment Of Vesicle Localization Signal Transduction Vesicle Localization Cell Differentiation Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Signaling Response To Stimulus Cell Communication Positive Regulation Of Amino Acid Transport Regulation Of Cellular Process Regulation Of Glutamate Secretion Regulation Of Glomerular Filtration Positive Regulation Of SMAD Protein Import Into Nucleus
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