DPYSL5

Description		dihydropyrimidinase like 5
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GO Annotations	Cellular Component	Cytoplasm Cytosol Dendrite Protein-containing Complex Neuronal Cell Body Synapse Glutamatergic Synapse
	Molecular Function	Dihydropyrimidinase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides
	Biological Process	Pyrimidine Nucleobase Catabolic Process Signal Transduction Nervous System Development Axon Guidance Neuron Differentiation Negative Regulation Of Dendrite Morphogenesis
Pathways		CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fasting insulin ( 34059833) Obesity-related traits ( 23251661) Reflection (response to stress) ( 30886212) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31578528) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) White blood cell count ( 32888494)
Novel Interacting Genes		1 novel interacting genes: FBN2
Interacting Genes		9 interacting genes: APPL1 CFAP161 DARS2 DPYS DPYSL2 DPYSL3 DPYSL4 FES HSPA5
Entrez ID		56896
HPRD ID		10522
Ensembl ID		ENSG00000157851
Uniprot IDs		Q9BPU6
PDB IDs		4B90 4B91 4B92
Enriched GO Terms of Interacting Partners?		Dihydropyrimidinase Activity Pyrimidine Nucleobase Catabolic Process Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Pyrimidine Nucleobase Metabolic Process Pyrimidine-containing Compound Catabolic Process Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Pyrimidine-containing Compound Metabolic Process Filamin Binding Regulation Of Cell Motility Regulation Of Locomotion Nucleobase-containing Small Molecule Metabolic Process Phosphoprotein Binding Maintenance Of Protein Location Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Aspartate-tRNA(Asn) Ligase Activity Mitochondrial Asparaginyl-tRNA Aminoacylation Small Molecule Metabolic Process Hydrolase Activity Uracil Catabolic Process Maintenance Of Location Cerebellum Structural Organization Positive Regulation Of Macropinocytosis Aspartyl-tRNA Aminoacylation Aspartate-tRNA Ligase Activity Thymine Metabolic Process Thymine Catabolic Process Regulation Of Cell Migration Sequestering Of TGFbeta In Extracellular Matrix Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Phosphatidylinositol Binding Asparaginyl-tRNA Aminoacylation Cytoplasm CMP Catabolic Process DUMP Catabolic Process Regulation Of ATF6-mediated Unfolded Protein Response UMP Catabolic Process Catabolic Process DCMP Catabolic Process Macropinosome Positive Regulation Of Neuron Projection Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Nervous System Development Pyrimidine Ribonucleotide Catabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Pinocytosis Bone Trabecula Formation Post-translational Protein Targeting To Membrane, Translocation Adiponectin-activated Signaling Pathway
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