DPYSL5

Gene Name		dihydropyrimidinase-like 5
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Gene Ontology Annotations	Cellular Component	Cytosol Dendrite Neuronal Cell Body
	Molecular Function	Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides
	Biological Process	Pyrimidine Nucleobase Catabolic Process Signal Transduction Nervous System Development Axon Guidance
Pathways		Axon guidance Semaphorin interactions CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Fasting glucose-related traits (interaction with BMI) ( 22581228) Obesity-related traits ( 23251661)
Protein-protein Interactions		8 interactors: APPL1 DARS2 DPYS DPYSL2 DPYSL3 DPYSL4 FES HSPA5
Entrez ID		56896
HPRD ID		10522
Ensembl ID		ENSG00000157851
Uniprot IDs		Q9BPU6
PDB IDs		4B90 4B91 4B92
Enriched GO Terms of Interacting Partners?		Pyrimidine Nucleobase Catabolic Process Pyrimidine Nucleobase Metabolic Process Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Nucleobase-containing Small Molecule Metabolic Process Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Catabolic Process Response To External Stimulus Neuron Development Regulation Of Neuron Projection Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Mitochondrial Asparaginyl-tRNA Aminoacylation Regulation Of Protein Folding In Endoplasmic Reticulum Nervous System Development Small Molecule Metabolic Process Regulation Of Cell Projection Organization Locomotion Anatomical Structure Morphogenesis Regulation Of Neuron Differentiation Cerebellum Structural Organization Uracil Catabolic Process Movement Of Cell Or Subcellular Component Regulation Of Cell Motility Beta-alanine Metabolic Process Uracil Metabolic Process Thymine Metabolic Process Thymine Catabolic Process Generation Of Neurons Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Neurogenesis Neurogenesis Positive Regulation Of Glutamate Secretion TRNA Aminoacylation For Mitochondrial Protein Translation Cell Development Regulation Of Cell Development Regulation Of Cellular Component Organization Positive Regulation Of Neuron Projection Development Asparaginyl-tRNA Aminoacylation Protein Homooligomerization ER Overload Response
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