PDCD5 and KIAA1377

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PDCD5	KIAA1377
Gene Name		programmed cell death 5	KIAA1377
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Extracellular Vesicular Exosome	Cytoplasm Centrosome Midbody Ciliary Base
	Molecular Function	DNA Binding Protein Binding Heparin Binding Acetyltransferase Activator Activity Beta-tubulin Binding	Protein Binding
	Biological Process	Negative Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Protein Import Into Mitochondrial Outer Membrane Negative Regulation Of Chaperone-mediated Protein Folding	Mitotic Spindle Organization Cytoplasmic Microtubule Organization Cilium Assembly
Pathways
Drugs
Diseases
GWAS		Major depressive disorder ( 23377640)
Protein-Protein Interactions		10 interactors: ACP5 EEF1G KAT5 KDM1A KIAA1377 LRIF1 NUDT3 UBE2D3 UTP14A VHL	86 interactors: AIMP2 AKTIP ARIH2 ATP6V1F ATRX BMI1 BRD1 C11orf58 CDKN2B CRCT1 CSTF2 DGCR6 DISC1 DLEU1 DNM1 DUSP12 DUSP23 EIF2S2 EIF6 EPN1 FAM118B FAM134A FEZ1 FGFR3 FXR1 GEMIN7 GET4 GIT1 GOLGB1 GPRASP2 GSTO1 HMOX2 HTT ING5 KAT5 KAT7 KIF15 KLHL20 LAMTOR5 LPL LRRC1 LUC7L2 MAD2L1BP MAPK9 MRPS6 NAP1L5 NAT9 NPM3 NSF NUDT21 ODF2L OFD1 PBK PDCD5 PFDN1 PIK3R3 PMF1 POLD1 POLR2M PPP1CA PPP1CC PRKRA PTPRS RAB27A RAN RBM23 RGS2 RIF1 ROGDI RPA2 RUVBL1 SAT1 SNRPG SPDL1 STAU2 TFG TNFRSF14 TNFSF11 TOMM20 TTR TXNDC9 VIM YAE1D1 YWHAZ ZBED8 ZNF24
Entrez ID		9141	57562
HPRD ID		06843	17212
Ensembl ID		ENSG00000105185	ENSG00000110318
Uniprot IDs		B4DE64 O14737	Q9P2H0
PDB IDs		1YYB 2CRU 2K6B
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Cytokine Production Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Diphosphoinositol Polyphosphate Catabolic Process Diadenosine Polyphosphate Catabolic Process Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Transcription, DNA-templated Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Superoxide Anion Generation Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Oxygen Levels Cellular Nitrogen Compound Metabolic Process Regulation Of Cytokine Production Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nitrogen Compound Metabolic Process Riboflavin Metabolic Process Cellular Metabolic Process Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Positive Regulation Of Megakaryocyte Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hormone Biosynthetic Process Regulation Of Superoxide Anion Generation Proteasomal Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Nitric Oxide Biosynthetic Process RNA Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Hypoxia Cellular Aromatic Compound Metabolic Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Granulocyte Differentiation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Megakaryocyte Differentiation	Organelle Organization Cell Cycle Mitotic Cell Cycle Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cellular Metabolic Process Mitotic Cell Cycle Process Cellular Process Response To Light Stimulus Response To Radiation Triglyceride Catabolic Process Gene Expression Positive Regulation Of Apoptotic Signaling Pathway Organelle Localization Acylglycerol Catabolic Process Endomembrane System Organization Establishment Of Organelle Localization Cell Cycle Process Positive Regulation Of Signal Transduction Peptidyl-lysine Modification Endosome Organization Protein Localization To Organelle Positive Regulation Of Metabolic Process Anatomical Structure Development System Development Regulation Of Signal Transduction Termination Of RNA Polymerase II Transcription Cytoplasmic Transport Programmed Cell Death Chromosome Organization Cell Division Ribosomal Subunit Export From Nucleus Cell Death Regulation Of Signaling Cellular Response To Stimulus Death Histone H3 Acetylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Ubiquitination Mitotic Nuclear Division Ribonucleoprotein Complex Biogenesis Response To Abiotic Stimulus Positive Regulation Of Striated Muscle Contraction Cellular Response To Organic Substance RNA Metabolic Process Organ Development Neurotransmitter Uptake
Tagcloud ?		ablation cascade conversely defective diminishes efficiently genotoxic hybrid ineffectiveness interacting knocking linking obscure overcame programmed proteosomal rescued restoration reversed screen strikingly substantially tp53 uncovered yaf2 yy1
Tagcloud (Difference) ?		ablation cascade conversely defective diminishes efficiently genotoxic hybrid ineffectiveness interacting knocking linking obscure overcame programmed proteosomal rescued restoration reversed screen strikingly substantially tp53 uncovered yaf2 yy1
Tagcloud (Intersection) ?