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NPDC1 and E2F1
Number of citations of the paper that reports this interaction (PMID
11042687
)
2
Data Source:
HPRD
(two hybrid, in vivo, in vitro)
NPDC1
E2F1
Gene Name
neural proliferation, differentiation and control, 1
E2F transcription factor 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Integral Component Of Membrane
Nucleus
Nucleoplasm
Cytoplasm
Rb-E2F Complex
Molecular Function
Core Promoter Binding
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Sequence-specific DNA Binding
Biological Process
DNA Damage Checkpoint
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Mitotic Cell Cycle
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Apoptotic Process
Notch Signaling Pathway
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Gene Expression
Forebrain Development
Anoikis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Fibroblast Proliferation
MRNA Stabilization
Cellular Response To Fatty Acid
Cellular Response To Hypoxia
Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Lens Fiber Cell Apoptotic Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Cellular Senescence
Activation of BH3-only proteins
Oncogene Induced Senescence
Assembly of the pre-replicative complex
Pre-NOTCH Transcription and Translation
G2 Phase
G1/S Transition
G1/S-Specific Transcription
Programmed Cell Death
Pre-NOTCH Expression and Processing
Mitotic G1-G1/S phases
Intrinsic Pathway for Apoptosis
E2F mediated regulation of DNA replication
Signaling by NOTCH
DNA Replication Pre-Initiation
G1 Phase
M/G1 Transition
Regulation of DNA replication
G0 and Early G1
CDC6 association with the ORC:origin complex
Cell Cycle, Mitotic
Activation of NOXA and translocation to mitochondria
Cyclin D associated events in G1
Oxidative Stress Induced Senescence
Activation of PUMA and translocation to mitochondria
Association of licensing factors with the pre-replicative complex
Mitotic G2-G2/M phases
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs
Diseases
GWAS
Protein-Protein Interactions
21 interactors:
CCND1
CCND2
CCND3
CDK2
CPT1A
E2F1
HINFP
HNRNPK
KHDRBS2
KRTAP10-1
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-9
KRTAP4-12
KRTAP5-9
MADD
MDFI
NOTCH2NL
PLSCR1
TFDP1
70 interactors:
ARID3A
ATAD2
ATM
ATR
BRCA1
BRD2
BTRC
CCNA1
CCNA2
CDK1
CDK2
CDK3
CDK7
CDKN2A
CEBPE
CHEK2
CREBBP
CTDP1
CUL1
DDB2
E2F6
ERCC3
FHL2
GSK3B
GTF2H1
HCFC1
IGF1
KAT5
KDM1A
MDM2
MDM4
MGA
MNAT1
MYBL2
NCOA3
NCOA6
NCOR2
NDN
NDNL2
NFKB1
NPDC1
NRIP1
PARP1
PHB
PKIB
PRDM2
PURA
RARA
RB1
RNF144A
SERTAD2
SETD7
SKP2
SP1
SP2
SP3
SP4
SPIB
STAT1
STOML1
TBP
TEAD3
TFDP1
TFDP2
TOPBP1
TP53
TP53BP1
TRRAP
VHL
YWHAQ
Entrez ID
56654
1869
HPRD ID
12048
01806
Ensembl ID
ENSG00000107281
ENSG00000101412
Uniprot IDs
Q9NQX5
Q01094
Q9BSD8
PDB IDs
1H24
1O9K
2AZE
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Positive Regulation Of Protein Serine/threonine Kinase Activity
Notch Signaling Pathway
DNA Damage Checkpoint
Anoikis
Positive Regulation Of Protein Kinase Activity
Cell Cycle
Positive Regulation Of Kinase Activity
Cell Cycle Checkpoint
Regulation Of Cell Cycle
Regulation Of Metabolic Process
Positive Regulation Of Transferase Activity
Positive Regulation Of Cell Cycle
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Mitotic Cell Cycle Process
Positive Regulation Of Protein Phosphorylation
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Kinase Activity
Mitotic Cell Cycle
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Kinase Activity
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Cell Division
Positive Regulation Of Phosphorylation
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Protein Modification Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Catalytic Activity
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Gene Expression
Transcription, DNA-templated
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Catalytic Activity
RNA Biosynthetic Process
Cellular Response To Stimulus
Cell Cycle Process
Regulation Of Mitotic Cell Cycle Phase Transition
Cellular Response To Fatty Acid
Regulation Of Transcription, DNA-templated
Regulation Of Protein Phosphorylation
Positive Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Nitrogen Compound Metabolic Process
RNA Metabolic Process
Regulation Of Metabolic Process
Nitrogen Compound Metabolic Process
Transcription From RNA Polymerase II Promoter
Gene Expression
Biosynthetic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Gene Expression
Regulation Of Cell Cycle
Negative Regulation Of Biosynthetic Process
Cellular Metabolic Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Process
Cell Cycle Phase Transition
Cellular Response To DNA Damage Stimulus
Transcription Initiation From RNA Polymerase II Promoter
Mitotic Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Cell Cycle
Mitotic Cell Cycle Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cellular Process
DNA Repair
Cellular Response To Stress
DNA-templated Transcription, Initiation
Intracellular Steroid Hormone Receptor Signaling Pathway
G1/S Transition Of Mitotic Cell Cycle
Tagcloud
?
box
coexpression
consensus
delays
displaying
dp
dps
e2fs
ectopic
emphasizes
exit
heterodimerization
heterodimers
lacks
members
namely
pocket
possesses
possessing
preference
quiescent
refer
shares
suppresses
transactivational
tttcccgc
tttcgcgc
unlike
Tagcloud (Difference)
?
box
coexpression
consensus
delays
displaying
dp
dps
e2fs
ectopic
emphasizes
exit
heterodimerization
heterodimers
lacks
members
namely
pocket
possesses
possessing
preference
quiescent
refer
shares
suppresses
transactivational
tttcccgc
tttcgcgc
unlike
Tagcloud (Intersection)
?