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NPDC1 and CCND1
Number of citations of the paper that reports this interaction (PubMedID
11042687
)
0
Data Source:
HPRD
(in vitro)
NPDC1
CCND1
Description
neural proliferation, differentiation and control 1
cyclin D1
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Membrane
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytoplasm
Microtubule Organizing Center
Cytosol
Bicellular Tight Junction
Membrane
Transcription Repressor Complex
Nuclear Membrane
Cyclin D1-CDK4 Complex
Cyclin D1-CDK6 Complex
Molecular Function
Protein Binding
Transcription Corepressor Activity
Protein Kinase Activity
Protein Binding
Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Enzyme Binding
Protein Kinase Binding
Histone Deacetylase Binding
Protein Serine/threonine Kinase Activator Activity
Protein-containing Complex Binding
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Proline-rich Region Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Re-entry Into Mitotic Cell Cycle
Liver Development
DNA Damage Response
Lactation
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Iron Ion
Response To X-ray
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Wnt Signaling Pathway
Neuron Differentiation
Negative Regulation Of Epithelial Cell Differentiation
Endoplasmic Reticulum Unfolded Protein Response
Animal Organ Regeneration
Mitotic G1 DNA Damage Checkpoint Signaling
Response To Magnesium Ion
Response To Estradiol
Response To Vitamin E
Leydig Cell Differentiation
Mammary Gland Epithelial Cell Proliferation
Positive Regulation Of Mammary Gland Epithelial Cell Proliferation
Negative Regulation Of Neuron Apoptotic Process
Response To Estrogen
Response To Leptin
Fat Cell Differentiation
Response To Ethanol
Response To Steroid Hormone
Cell Division
Response To Glucocorticoid
Response To Corticosterone
Response To Calcium Ion
Regulation Of Cell Cycle
Mammary Gland Alveolus Development
Response To UV-A
Liver Regeneration
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
SCF(Skp2)-mediated degradation of p27/p21
Pre-NOTCH Transcription and Translation
RMTs methylate histone arginines
Interleukin-4 and Interleukin-13 signaling
Cyclin D associated events in G1
Ubiquitin-dependent degradation of Cyclin D
Ubiquitin-dependent degradation of Cyclin D
PTK6 Regulates Cell Cycle
Transcriptional Regulation by VENTX
Transcriptional regulation by RUNX2
Regulation of RUNX1 Expression and Activity
RUNX3 regulates WNT signaling
RUNX3 regulates p14-ARF
Estrogen-dependent gene expression
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drug-mediated inhibition of CDK4/CDK6 activity
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
SPOP-mediated proteasomal degradation of PD-L1(CD274)
Drugs
Acetylsalicylic acid
Arsenic trioxide
Encorafenib
Bryostatin 1
Diseases
Breast cancer
Hairy-cell leukemia
Oral cancer
Multiple myeloma
Laryngeal cancer
von Hippel-Lindau syndrome
Esophageal cancer
GWAS
Lymphocyte count (
27863252
)
Monocyte percentage of white cells (
27863252
32888494
)
White blood cell count (
27863252
32888494
)
Adult body size (
32376654
)
Birth weight (
31043758
)
Blond vs. brown/black hair color (
30531825
)
Body fat distribution (arm fat ratio) (
30664634
)
Breast cancer (
20453838
29059683
)
Breast cancer (early onset) (
24493630
)
Breast size (
22747683
27182965
)
Cerebral microbleeds (
32913026
)
Craniofacial microsomia (
26853712
)
Cutaneous malignant melanoma (
26237428
32341527
)
Diastolic blood pressure (
27841878
)
Height (
25429064
)
Hip circumference (
25673412
)
Hip circumference adjusted for BMI (
34021172
)
Hip index (
34021172
)
Idiopathic dilated cardiomyopathy (
29495422
)
Immunoglobulin light chain (AL) amyloidosis (
28025584
)
Melanoma (
28212542
)
Multiple myeloma (IgH translocation) (
23502783
)
Nevus count or cutaneous melanoma (
30429480
32341527
)
Offspring birth weight (
31043758
)
Refractive error (
32231278
)
Total body bone mineral density (
29304378
)
Type 2 diabetes (
32499647
30718926
30297969
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
White blood cell count (
32888494
)
Interacting Genes
41 interacting genes:
C3orf52
CCND1
CCND2
CCND3
CDK2
CPT1A
CYSRT1
E2F1
EMD
FHL5
HINFP
HNRNPK
KHDRBS2
KRTAP1-1
KRTAP1-3
KRTAP10-1
KRTAP10-3
KRTAP10-5
KRTAP10-6
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-2
KRTAP12-3
KRTAP2-3
KRTAP2-4
KRTAP4-1
KRTAP4-12
KRTAP4-4
KRTAP5-9
KRTAP9-3
MADD
MAL
MDFI
MS4A13
NBPF19
NOTCH2NLA
PLSCR1
RBMY1F
RBMY1J
TFDP1
82 interacting genes:
AKAP8
AMBRA1
AR
ARID4A
ATF2
BCAS3
BRCA1
BRCA2
BRINP1
BTRC
CALM1
CAMK1
CCNDBP1
CDC14B
CDH13
CDK4
CDK6
CDK8
CDKN1A
CDKN1B
CRYAB
CTNNB1
CUL3
DMTF1
DZIP3
EP300
ESR1
FANCC
FBXO31
FBXO4
FOS
GSK3B
HDAC3
HERC5
IFI27
IGFBP3
INSM1
JUN
JUND
KAT2B
KLK7
KLK9
LPL
MAPK11
MCM10
MCM7
MYBL2
NCOA1
NCOA3
NPDC1
ORC4
PCNA
POLR1B
PPP3R2
PRKACA
PRKN
RABEP1
RAD51
RANBP9
RB1
RBL1
RBL2
RBX1
RFC1
RUNX1
SMAD1
SP1
STAT3
TAF1
TBC1D2
TDRD7
THRA
THRB
TP73
TRMO
TSC2
TSTD2
UBTF
UHRF2
USP13
XPO1
ZNF510
Entrez ID
56654
595
HPRD ID
12048
01346
Ensembl ID
ENSG00000107281
ENSG00000110092
Uniprot IDs
Q9NQX5
P24385
Q6FI00
PDB IDs
2W96
2W99
2W9F
2W9Z
5VZU
6P8E
6P8F
6P8G
6P8H
Enriched GO Terms of Interacting Partners
?
Intermediate Filament
Keratin Filament
Cell Cycle G1/S Phase Transition
G1/S Transition Of Mitotic Cell Cycle
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Cyclin-dependent Protein Kinase Holoenzyme Complex
Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Cell Cycle G1/S Phase Transition
Cytosol
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Negative Regulation Of Fat Cell Proliferation
Rb-E2F Complex
Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Mitotic Cell Cycle Phase Transition
DNA Damage Checkpoint Signaling
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of MRNA Splicing, Via Spliceosome
Positive Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Regulation Of MRNA Processing
Anoikis
Positive Regulation Of Cell Cycle Process
Signal Transduction In Response To DNA Damage
Hair Cycle
Protein Serine/threonine Kinase Activator Activity
Identical Protein Binding
Mitotic G1 DNA Damage Checkpoint Signaling
Mitotic G1/S Transition Checkpoint Signaling
Regulation Of Cell Cycle
Regulation Of RNA Splicing
Positive Regulation Of Cell Cycle
Regulation Of MRNA Metabolic Process
Regulation Of Mitotic Cell Cycle
Microtubule Organizing Center
Response To X-ray
Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of MRNA Splicing, Via Spliceosome
Negative Regulation Of Cell Cycle Phase Transition
Liver Regeneration
TMEM240-body
Protein Insertion Into Plasma Membrane
Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane
Nucleoplasm
Regulation Of Cell Cycle
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Metabolic Process
Intracellular Signal Transduction
Positive Regulation Of Biosynthetic Process
Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
DNA-templated Transcription
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Cell Population Proliferation
Cellular Response To Stress
Positive Regulation Of RNA Metabolic Process
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Response To Hormone
DNA Binding
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Cellular Response To Oxygen-containing Compound
Negative Regulation Of Biosynthetic Process
Cyclin Binding
Macromolecule Metabolic Process
Regulation Of Cell Cycle Process
Negative Regulation Of RNA Metabolic Process
Cellular Response To Hormone Stimulus
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Transcription Regulator Complex
Nucleic Acid Metabolic Process
Ubiquitin Protein Ligase Binding
Negative Regulation Of Macromolecule Metabolic Process
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