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NPDC1 and CCND1
Number of citations of the paper that reports this interaction (PMID
11042687
)
2
Data Source:
HPRD
(in vitro)
NPDC1
CCND1
Gene Name
neural proliferation, differentiation and control, 1
cyclin D1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Integral Component Of Membrane
Cyclin-dependent Protein Kinase Holoenzyme Complex
Intracellular
Nucleus
Nucleoplasm
Cytosol
Tight Junction
Membrane
Transcriptional Repressor Complex
Molecular Function
Transcription Corepressor Activity
Protein Kinase Activity
Protein Binding
Transcription Factor Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Enzyme Binding
Protein Kinase Binding
Protein Complex Binding
Histone Deacetylase Binding
Proline-rich Region Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Mitotic Cell Cycle
Re-entry Into Mitotic Cell Cycle
Liver Development
Positive Regulation Of Protein Phosphorylation
Chromatin Organization
Transcription, DNA-templated
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
Notch Signaling Pathway
Lactation
Response To Iron Ion
Response To X-ray
Response To Organonitrogen Compound
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Wnt Signaling Pathway
Negative Regulation Of Epithelial Cell Differentiation
Endoplasmic Reticulum Unfolded Protein Response
Organ Regeneration
Mitotic G1 DNA Damage Checkpoint
Response To Magnesium Ion
Response To Vitamin E
Leydig Cell Differentiation
Mammary Gland Epithelial Cell Proliferation
Positive Regulation Of Mammary Gland Epithelial Cell Proliferation
Response To Drug
Response To Estrogen
Fat Cell Differentiation
Response To Ethanol
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Cell Division
Response To Corticosterone
Response To Calcium Ion
Canonical Wnt Signaling Pathway
Mammary Gland Alveolus Development
Response To UV-A
Negative Regulation Of Cell Cycle Arrest
Pathways
Chromatin organization
Signaling by NOTCH
Ubiquitin-dependent degradation of Cyclin D
G1 Phase
S Phase
Cell Cycle, Mitotic
RMTs methylate histone arginines
Ubiquitin-dependent degradation of Cyclin D1
Cyclin D associated events in G1
Chromatin modifying enzymes
Pre-NOTCH Transcription and Translation
Pre-NOTCH Expression and Processing
Mitotic G1-G1/S phases
Drugs
Arsenic trioxide
Diseases
GWAS
Breast cancer (
20453838
)
Breast size (
22747683
)
Multiple myeloma (IgH translocation) (
23502783
)
Protein-Protein Interactions
21 interactors:
CCND1
CCND2
CCND3
CDK2
CPT1A
E2F1
HINFP
HNRNPK
KHDRBS2
KRTAP10-1
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-9
KRTAP4-12
KRTAP5-9
MADD
MDFI
NOTCH2NL
PLSCR1
TFDP1
60 interactors:
AKAP8
AR
ARID4A
ATF2
BRCA1
BRINP1
BTRC
CALM1
CAMK1
CCNDBP1
CDK4
CDK6
CDKN1A
CDKN1B
CDKN1C
CDKN2A
CRYAB
CTNNB1
CUL3
DMTF1
EP300
ESR1
FBXO31
FBXO4
GSK3B
HDAC3
HERC5
IFI27
INSM1
KAT2B
LPL
MAPK11
MCM10
MCM7
MYBL2
NCOA1
NCOA3
NPDC1
ORC4
PCNA
POLR1B
PRKACA
RABEP1
RB1
RBL1
RBL2
RBX1
RFC1
RUNX1
SP1
STAT3
TAF1
THRA
THRB
TP73
TSC2
UBTF
UHRF2
USP2
XPO1
Entrez ID
56654
595
HPRD ID
12048
01346
Ensembl ID
ENSG00000107281
ENSG00000110092
Uniprot IDs
Q9NQX5
P24385
Q6FI00
PDB IDs
2W96
2W99
2W9F
2W9Z
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Positive Regulation Of Protein Serine/threonine Kinase Activity
Notch Signaling Pathway
DNA Damage Checkpoint
Anoikis
Positive Regulation Of Protein Kinase Activity
Cell Cycle
Positive Regulation Of Kinase Activity
Cell Cycle Checkpoint
Regulation Of Cell Cycle
Regulation Of Metabolic Process
Positive Regulation Of Transferase Activity
Positive Regulation Of Cell Cycle
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Mitotic Cell Cycle Process
Positive Regulation Of Protein Phosphorylation
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Kinase Activity
Mitotic Cell Cycle
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Kinase Activity
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Cell Division
Positive Regulation Of Phosphorylation
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Protein Modification Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Catalytic Activity
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Gene Expression
Transcription, DNA-templated
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Catalytic Activity
RNA Biosynthetic Process
Cellular Response To Stimulus
Cell Cycle Process
Regulation Of Mitotic Cell Cycle Phase Transition
Cellular Response To Fatty Acid
Regulation Of Transcription, DNA-templated
Regulation Of Protein Phosphorylation
Cell Cycle
Regulation Of Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Cell Cycle Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Macromolecule Biosynthetic Process
Mitotic Cell Cycle
Regulation Of Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Gene Expression
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Response To Organic Substance
Cellular Response To Organic Substance
Negative Regulation Of Cell Cycle
Negative Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Chromosome Organization
Regulation Of Phosphorylation
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Gene Expression
Mitotic Cell Cycle Process
Regulation Of Protein Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Phosphorus Metabolic Process
Regulation Of Kinase Activity
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Protein Phosphorylation
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Phosphorylation
Negative Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Mitotic Cell Cycle
Cell Cycle Arrest
Transcription, DNA-templated
Cellular Response To Stimulus
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Protein Kinase Activity
RNA Biosynthetic Process
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Kinase Activity
Cellular Metabolic Process
Cellular Macromolecule Biosynthetic Process
Tagcloud
?
11q13
4nqo
7f4
amplicon
amplification
amplified
cavity
chr
distal
example
fgf3
fgf4
heterozygosity
hras1
inbred
inconsistently
involving
loh
murine
neck
nitroquinoline
portion
predispose
scc
strikingly
syntenic
telomeric
thirds
twofold
Tagcloud (Difference)
?
11q13
4nqo
7f4
amplicon
amplification
amplified
cavity
chr
distal
example
fgf3
fgf4
heterozygosity
hras1
inbred
inconsistently
involving
loh
murine
neck
nitroquinoline
portion
predispose
scc
strikingly
syntenic
telomeric
thirds
twofold
Tagcloud (Intersection)
?