NPDC1 and CPT1A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NPDC1	CPT1A
Description		neural proliferation, differentiation and control 1	carnitine palmitoyltransferase 1A
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Mitochondrion Mitochondrial Outer Membrane Membrane
	Molecular Function	Protein Binding	Carnitine O-palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-macromolecule Adaptor Activity Identical Protein Binding
	Biological Process		Response To Hypoxia Long-chain Fatty Acid Metabolic Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Glucose Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Triglyceride Metabolic Process Carnitine Shuttle Response To Nutrient Response To Xenobiotic Stimulus Carnitine Metabolic Process Epithelial Cell Differentiation Response To Nutrient Levels Positive Regulation Of Fatty Acid Beta-oxidation Eating Behavior Response To Alkaloid Positive Regulation Of Innate Immune Response Response To Ethanol Aflatoxin Metabolic Process Regulation Of Fatty Acid Oxidation Regulation Of Insulin Secretion Cellular Response To Fatty Acid Liver Regeneration Response To Tetrachloromethane
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PPARA activates gene expression Carnitine shuttle RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs			Levocarnitine Glyburide Perhexiline
Diseases			Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS		Lymphocyte count ( 27863252) Monocyte percentage of white cells ( 27863252 32888494) White blood cell count ( 27863252 32888494)	Apolipoprotein A1 levels ( 32203549) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) HDL cholesterol levels ( 32203549) Lipid metabolism phenotypes ( 22286219) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Obesity-related traits ( 23251661) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32154731 32203549) Urate levels ( 31578528)
Interacting Genes		41 interacting genes: C3orf52 CCND1 CCND2 CCND3 CDK2 CPT1A CYSRT1 E2F1 EMD FHL5 HINFP HNRNPK KHDRBS2 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP4-1 KRTAP4-12 KRTAP4-4 KRTAP5-9 KRTAP9-3 MADD MAL MDFI MS4A13 NBPF19 NOTCH2NLA PLSCR1 RBMY1F RBMY1J TFDP1	8 interacting genes: BCL2 CLIC1 CYBA HSPA5 KBTBD7 NPDC1 NR4A1 UBC
Entrez ID		56654	1374
HPRD ID		12048	02755
Ensembl ID		ENSG00000107281	ENSG00000110090
Uniprot IDs		Q9NQX5	B2RAQ8 P50416 Q8WZ48
PDB IDs			2LE3
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Cytosol Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Negative Regulation Of Fat Cell Proliferation Rb-E2F Complex Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Signaling Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of MRNA Processing Anoikis Positive Regulation Of Cell Cycle Process Signal Transduction In Response To DNA Damage Hair Cycle Protein Serine/threonine Kinase Activator Activity Identical Protein Binding Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Regulation Of Cell Cycle Regulation Of RNA Splicing Positive Regulation Of Cell Cycle Regulation Of MRNA Metabolic Process Regulation Of Mitotic Cell Cycle Microtubule Organizing Center Response To X-ray Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Cell Cycle Phase Transition Liver Regeneration TMEM240-body Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane	Negative Regulation Of Retinal Cell Programmed Cell Death Ubiquitin Protein Ligase Binding Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Cellular PH Reduction Neural Nucleus Development Cellular Response To Glucose Starvation Protein Heterodimerization Activity Nuclear Membrane Response To Gamma Radiation Mitochondrion Smooth Muscle Hypertrophy Negative Regulation Of Glomerular Filtration By Angiotensin Regulation Of Protein Folding In Endoplasmic Reticulum Reactive Oxygen Species Metabolic Process CD8-positive, Alpha-beta T Cell Lineage Commitment BAD-BCL-2 Complex Channel Inhibitor Activity Endoplasmic Reticulum Membrane Positive Regulation Of Endothelial Cell Proliferation Cerebellum Structural Organization Negative Regulation Of Calcium Ion Transport Into Cytosol Response To Nutrient Levels Regulation Of Calcium Ion Transmembrane Transport Dendritic Cell Apoptotic Process Cochlear Nucleus Development Protein Ubiquitination Regulation Of Melanocyte Differentiation Response To Hormone Regulation Of Nitrogen Utilization Response To Peptide Regulation Of Retinal Cell Programmed Cell Death Response To Ionizing Radiation Response To Cytokine Positive Regulation Of Melanocyte Differentiation Immune System Development Positive Regulation Of Neuron Maturation Retinal Cell Programmed Cell Death Response To Corticosteroid Cellular Response To L-glutamine Positive Regulation Of Mucus Secretion Regulation Of Renal Output By Angiotensin Regulation Of Endothelial Cell Proliferation Detection Of Lipopolysaccharide Cellular Response To Corticotropin-releasing Hormone Stimulus Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Cell Growth B Cell Lineage Commitment BH3 Domain Binding Positive Regulation Of Pigment Cell Differentiation Regulation Of Blood Volume By Renin-angiotensin
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