NPDC1 and CPT1A

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NPDC1	CPT1A
Gene Name		neural proliferation, differentiation and control, 1	carnitine palmitoyltransferase 1A (liver)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Membrane Integral Component Of Mitochondrial Outer Membrane
	Molecular Function		Carnitine O-palmitoyltransferase Activity Identical Protein Binding
	Biological Process		Long-chain Fatty Acid Metabolic Process Glucose Metabolic Process Fatty Acid Beta-oxidation Triglyceride Metabolic Process Carnitine Shuttle Circadian Rhythm Carnitine Metabolic Process Response To Organic Cyclic Compound Epithelial Cell Differentiation Positive Regulation Of Fatty Acid Beta-oxidation Response To Drug Eating Behavior Cellular Lipid Metabolic Process Small Molecule Metabolic Process Regulation Of Insulin Secretion Protein Homooligomerization Cellular Response To Fatty Acid
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Signaling by Retinoic Acid Import of palmitoyl-CoA into the mitochondrial matrix Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) RORA activates circadian gene expression
Drugs			L-Carnitine Perhexiline
Diseases
GWAS			Lipid metabolism phenotypes ( 22286219) Obesity-related traits ( 23251661)
Protein-Protein Interactions		21 interactors: CCND1 CCND2 CCND3 CDK2 CPT1A E2F1 HINFP HNRNPK KHDRBS2 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-9 KRTAP4-12 KRTAP5-9 MADD MDFI NOTCH2NL PLSCR1 TFDP1	7 interactors: BCL2 CLIC1 CYBA HSPA5 KBTBD7 NPDC1 NR4A1
Entrez ID		56654	1374
HPRD ID		12048	02755
Ensembl ID		ENSG00000107281	ENSG00000110090
Uniprot IDs		Q9NQX5	B2RAQ8 P50416 Q8WZ48
PDB IDs			2LE3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Protein Serine/threonine Kinase Activity Notch Signaling Pathway DNA Damage Checkpoint Anoikis Positive Regulation Of Protein Kinase Activity Cell Cycle Positive Regulation Of Kinase Activity Cell Cycle Checkpoint Regulation Of Cell Cycle Regulation Of Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Cell Cycle Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Process Positive Regulation Of Protein Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Kinase Activity Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Transcription, DNA-templated Cell Division Positive Regulation Of Phosphorylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Catalytic Activity Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Gene Expression Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Catalytic Activity RNA Biosynthetic Process Cellular Response To Stimulus Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Fatty Acid Regulation Of Transcription, DNA-templated Regulation Of Protein Phosphorylation	Cellular Response To Glucose Starvation Regulation Of Mitochondrial Membrane Potential Response To Gamma Radiation Neural Nucleus Development Positive Regulation Of Endothelial Cell Proliferation Response To Nutrient Levels Response To Extracellular Stimulus Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Endothelial Cell Proliferation Renal System Process Negative Regulation Of Cellular PH Reduction Smooth Muscle Hypertrophy CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Glomerular Filtration By Angiotensin Regulation Of Body Fluid Levels Reactive Oxygen Species Metabolic Process Regulation Of Ion Transport Response To Stress Positive Regulation Of Cell Growth Metencephalon Development Cell Activation Response To External Stimulus Response To Wounding Cerebellum Structural Organization Response To Cytokine Cellular Response To Starvation Cellular Response To Organic Substance Response To Ionizing Radiation Positive Regulation Of Epithelial Cell Proliferation Response To Endoplasmic Reticulum Stress Regulation Of Ion Homeostasis Innate Immune Response Regulation Of Retinal Cell Programmed Cell Death Positive Regulation Of Neuron Maturation Regulation Of Renal Output By Angiotensin Positive Regulation Of Cell Proliferation Hindbrain Development Response To Toxic Substance Cellular Response To Nutrient Levels Response To Starvation Response To Organic Cyclic Compound Cochlear Nucleus Development Regulation Of Nitrogen Utilization Regulation Of Calcium Ion Transport Platelet Activation Intracellular Receptor Signaling Pathway Regulation Of Ossification Negative Regulation Of Apoptotic Process
Tagcloud ?			adaptations advantageous ancestral briefly carnitine circulate coa expenditure famine hmg holds hypoglycemic inuit ketone krebs lipolysis maximize metabolize methylglutaryl modern nonfasting palmitoyl predispose reserves shortage stores thrifty toolkit
Tagcloud (Difference) ?			adaptations advantageous ancestral briefly carnitine circulate coa expenditure famine hmg holds hypoglycemic inuit ketone krebs lipolysis maximize metabolize methylglutaryl modern nonfasting palmitoyl predispose reserves shortage stores thrifty toolkit
Tagcloud (Intersection) ?