GBA1 and TRIP12

Number of citations of the paper that reports this interaction (PubMedID 34644545)
62

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		GBA1	TRIP12
Description		glucosylceramidase beta 1	thyroid hormone receptor interactor 12
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GO Annotations	Cellular Component	Extracellular Space Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Membrane Lysosomal Lumen Extracellular Exosome	Nucleus Nucleoplasm Cytosol Nuclear Speck
	Molecular Function	Galactosylceramidase Activity Glucosylceramidase Activity Signaling Receptor Binding Scavenger Receptor Binding Protein Binding Beta-glucosidase Activity Transferase Activity Glycosyltransferase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Glucosyltransferase Activity Steryl-beta-glucosidase Activity	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Nuclear Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Mitophagy Lipid Metabolic Process Sphingolipid Metabolic Process Glucosylceramide Metabolic Process Glucosylceramide Catabolic Process Autophagy Mitochondrion Organization Lysosome Organization Central Nervous System Development Steroid Metabolic Process Cholesterol Metabolic Process Determination Of Adult Lifespan Cellular Response To Starvation Response To PH Negative Regulation Of Macromolecule Metabolic Process Microglia Differentiation Regulation Of Macroautophagy Antigen Processing And Presentation Lipid Storage Cerebellar Purkinje Cell Layer Formation Pyramidal Neuron Differentiation Respiratory Electron Transport Chain Termination Of Signal Transduction Neuron Projection Development Negative Regulation Of Protein-containing Complex Assembly Regulation Of TOR Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interleukin-6 Production T Cell Differentiation In Thymus Response To Testosterone Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Cell Maturation Brain Morphogenesis Homeostasis Of Number Of Cells Negative Regulation Of Inflammatory Response Nervous System Process Neuromuscular Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Neuron Apoptotic Process Establishment Of Skin Barrier Microglial Cell Proliferation Motor Behavior Cellular Response To Tumor Necrosis Factor Hematopoietic Stem Cell Proliferation Response To Dexamethasone Lymphocyte Migration Response To Thyroid Hormone Skin Epidermis Development Beta-glucoside Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Neuronal Action Potential Autophagosome Organization Positive Regulation Of Type 2 Mitophagy Lysosomal Protein Catabolic Process Regulation Of Lysosomal Protein Catabolic Process	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination Heterochromatin Boundary Formation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Embryonic Development DNA Repair-dependent Chromatin Remodeling
Pathways		Association of TriC/CCT with target proteins during biosynthesis Glycosphingolipid catabolism	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		scyllo-inositol N-acetyl-alpha-D-glucosamine Velaglucerase alfa (2R,3R,4R,5S)-2-(HYDROXYMETHYL)-1-NONYLPIPERIDINE-3,4,5-TRIOL
Diseases		Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Gaucher disease
GWAS			Carotid intima media thickness x smoking interaction ( 32117412) Estimated glomerular filtration rate ( 31015462 31152163) Metabolite levels ( 23823483) Systolic blood pressure ( 30224653) Weight ( 28552196)
Interacting Genes		5 interacting genes: NEDD4 OGT PSAP SNCA TRIP12	31 interacting genes: ATF7IP CARNS1 CDKN2A CELSR3 CLSTN1 CUL2 DSCR9 ERG FBXW7 GBA1 LCOR MTNR1A MTNR1B MYC NAE1 NMI NRIP1 OGT PARP1 PTF1A SMAD4 SMAD9 SOX6 SRPK2 TAF10 THRB UBC UBE2D1 UBE2D2 UBE2L3 UBE4B
Entrez ID		2629	9320
HPRD ID		06973	05144
Ensembl ID		ENSG00000177628	ENSG00000153827
Uniprot IDs		A0A068F658 B7Z6S9 P04062	A0A6Q8PGG9 A0A6Q8PHK0 A0A994J4J0 A0A994J569 A0A994J755 H7C1L9 Q14669
PDB IDs		1OGS 1Y7V 2F61 2J25 2NSX 2NT0 2NT1 2V3D 2V3E 2V3F 2VT0 2WCG 2WKL 2XWD 2XWE 3GXD 3GXF 3GXI 3GXM 3KE0 3KEH 3RIK 3RIL 5LVX 6MOZ 6Q1N 6Q1P 6Q6K 6Q6L 6Q6N 6T13 6TJJ 6TJK 6TJQ 6TN1 6YTP 6YTR 6YUT 6YV3 6Z39 6Z3I 7NWV 8AWK 8AWR 8AX3 8P3E 8P41 9F9Z 9FA3 9FA6 9FAD 9FAL 9FAY 9FAZ 9FB2 9FDI	9BKR 9BKS
Enriched GO Terms of Interacting Partners?		Protein Domain Specific Binding Protein Localization To Lysosome Receptor Internalization Regulation Of Protein Catabolic Process Regulation Of Synapse Organization Regulation Of Autophagy Formation Of Structure Involved In A Symbiotic Process Regulation Of Lipid Metabolic Process Ganglioside GM3 Binding Ganglioside GP1c Binding Lipid Binding Positive Regulation Of Beta-galactosidase Activity Enzyme Activator Activity Ganglioside GM1 Transport To Membrane Ganglioside GM2 Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein Localization To Vacuole Channel Inhibitor Activity Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Heterochromatin Boundary Formation Phospholipid Binding Negative Regulation Of Protein Catabolic Process Lysosomal Transport Phosphothreonine Residue Binding Ganglioside GT1b Binding Ganglioside GM1 Binding Negative Regulation Of Serotonin Uptake Negative Regulation Of Protein-containing Complex Assembly Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Generation Of Precursor Metabolites And Energy Protein O-acetylglucosaminyltransferase Activity Perinuclear Region Of Cytoplasm Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Vacuolar Transport Negative Regulation Of Dopamine Metabolic Process Regulation Of Synapse Assembly Regulation Of Protein Localization To Cell Periphery Regulation Of Serotonin Uptake Cell Cortex Nuclear Receptor-mediated Corticosteroid Signaling Pathway Protein-containing Complex	Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Nuclear Estrogen Receptor Binding Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Ubiquitin Protein Ligase Binding Post-translational Protein Modification Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Modification By Small Protein Conjugation Protein Ubiquitination Modification-dependent Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Proteolysis Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Regulation Of Neuron Apoptotic Process Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Protein-containing Complex Ubiquitin-dependent Protein Catabolic Process Nucleus Negative Regulation Of DNA-templated Transcription DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Polyubiquitination Cell Cycle Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Melatonin Receptor Activity Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process
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