GBA

Gene Name		glucosidase, beta, acid
Image
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Glucosylceramidase Activity Receptor Binding Protein Binding
	Biological Process	Carbohydrate Metabolic Process Sphingolipid Metabolic Process Glucosylceramide Catabolic Process Glycosphingolipid Metabolic Process Response To PH Termination Of Signal Transduction Negative Regulation Of Interleukin-6 Production Regulation Of Water Loss Via Skin Response To Testosterone Positive Regulation Of Protein Dephosphorylation Negative Regulation Of MAP Kinase Activity Skin Morphogenesis Response To Estrogen Small Molecule Metabolic Process Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Negative Regulation Of Inflammatory Response Response To Glucocorticoid Cellular Response To Tumor Necrosis Factor Response To Thyroid Hormone
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism
Drugs		Myo-Inositol 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose Velaglucerase alfa (2R,3R,4R,5S)-2-(HYDROXYMETHYL)-1-NONYLPIPERIDINE-3,4,5-TRIOL
Diseases
GWAS		Parkinson's disease ( 22451204 21738487) Renal function-related traits (BUN) ( 22797727)
Protein-protein Interactions		2 interactors: NEDD4 PSAP
Entrez ID		2629
HPRD ID		06973
Ensembl ID		ENSG00000177628
Uniprot IDs		B7Z5G2 B7Z6S1 B7Z6S9 F5H241 J3KQG4 J3KQK9 P04062
PDB IDs		1OGS 1Y7V 2F61 2J25 2NSX 2NT0 2NT1 2V3D 2V3E 2V3F 2VT0 2WCG 2WKL 2XWD 2XWE 3GXD 3GXF 3GXI 3GXM 3KE0 3KEH 3RIK 3RIL
Enriched GO Terms of Interacting Partners?		Transmission Of Virus Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Development Involved In Symbiotic Interaction Progesterone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Glucocorticoid Receptor Signaling Pathway Cell Activation Neuronal Ion Channel Clustering Protein Targeting To Lysosome Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Lysosome Epithelial Cell Differentiation Involved In Prostate Gland Development Receptor Catabolic Process Neuron Development Prostate Gland Growth Protein Targeting To Vacuole Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Establishment Of Protein Localization To Vacuole Neuron Differentiation Regulation Of Potassium Ion Transmembrane Transporter Activity Neuron Maturation Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein K63-linked Ubiquitination Positive Regulation Of Protein Metabolic Process Endocardial Cushion Development Regulation Of Potassium Ion Transmembrane Transport Protein Monoubiquitination Receptor Internalization Vesicle-mediated Transport Lysosomal Transport Neuromuscular Junction Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Generation Of Neurons Respiratory Gaseous Exchange Regulation Of DNA-templated Transcription In Response To Stress Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Neurogenesis Cellular Response To UV Regulation Of Potassium Ion Transport Outflow Tract Morphogenesis Tissue Development Regulation Of Sodium Ion Transport Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Intracellular Signal Transduction Prostate Gland Development Platelet Degranulation Regulation Of Dendrite Morphogenesis Cell Development Intracellular Steroid Hormone Receptor Signaling Pathway
Tagcloud ?		ataxin atp13a2 atxn3 b12 cag cgg chediak coexist cytopathies fmr1 fragile gaucher glucocerebrosidase hereditary higashi idiopathic joseph kufor levodopa lyst machado park2 parkin parkinsonism pn polg1 premutation rakeb tremor